| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| C9orf78 | FKBP9 | ENSP00000361524 | ENSP00000242209 | chromosome 9 open reading frame 78 | FK506 binding protein 9, 63 kDa; PPIases accelerate the folding of proteins during protein synthesis | 0.538 |
| C9orf78 | H2AFV | ENSP00000361524 | ENSP00000308405 | chromosome 9 open reading frame 78 | H2A histone family, member V; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be [...] | 0.551 |
| C9orf78 | HERC4 | ENSP00000361524 | ENSP00000378624 | chromosome 9 open reading frame 78 | HECT and RLD domain containing E3 ubiquitin protein ligase 4; Probable E3 ubiquitin-protein ligase involved in either protein trafficking or in the distribution of cellular structures. Required for spermatozoon maturation and fertility, and for the removal of the cytoplasmic droplet of the spermatozoon. E3 ubiquitin-protein ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfer it to targeted substrates (By similarity) | 0.538 |
| C9orf78 | LIMD1 | ENSP00000361524 | ENSP00000273317 | chromosome 9 open reading frame 78 | LIM domains containing 1; Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates microRNA (miRNA)-mediated gene silencing and is essential for P-body formation and integrity. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Acts as a t [...] | 0.538 |
| C9orf78 | NUBP2 | ENSP00000361524 | ENSP00000262302 | chromosome 9 open reading frame 78 | nucleotide binding protein 2; Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins (By similarity) | 0.538 |
| FKBP9 | C9orf78 | ENSP00000242209 | ENSP00000361524 | FK506 binding protein 9, 63 kDa; PPIases accelerate the folding of proteins during protein synthesis | chromosome 9 open reading frame 78 | 0.538 |
| FKBP9 | H2AFV | ENSP00000242209 | ENSP00000308405 | FK506 binding protein 9, 63 kDa; PPIases accelerate the folding of proteins during protein synthesis | H2A histone family, member V; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be [...] | 0.547 |
| FKBP9 | HERC4 | ENSP00000242209 | ENSP00000378624 | FK506 binding protein 9, 63 kDa; PPIases accelerate the folding of proteins during protein synthesis | HECT and RLD domain containing E3 ubiquitin protein ligase 4; Probable E3 ubiquitin-protein ligase involved in either protein trafficking or in the distribution of cellular structures. Required for spermatozoon maturation and fertility, and for the removal of the cytoplasmic droplet of the spermatozoon. E3 ubiquitin-protein ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfer it to targeted substrates (By similarity) | 0.546 |
| FKBP9 | LIMD1 | ENSP00000242209 | ENSP00000273317 | FK506 binding protein 9, 63 kDa; PPIases accelerate the folding of proteins during protein synthesis | LIM domains containing 1; Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates microRNA (miRNA)-mediated gene silencing and is essential for P-body formation and integrity. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Acts as a t [...] | 0.538 |
| FKBP9 | NUBP2 | ENSP00000242209 | ENSP00000262302 | FK506 binding protein 9, 63 kDa; PPIases accelerate the folding of proteins during protein synthesis | nucleotide binding protein 2; Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins (By similarity) | 0.538 |
| FKBP9 | PHKG1 | ENSP00000242209 | ENSP00000297373 | FK506 binding protein 9, 63 kDa; PPIases accelerate the folding of proteins during protein synthesis | phosphorylase kinase, gamma 1 (muscle); Catalytic subunit of the phosphorylase b kinase (PHK), which mediates the neural and hormonal regulation of glycogen breakdown (glycogenolysis) by phosphorylating and thereby activating glycogen phosphorylase. In vitro, phosphorylates PYGM, TNNI3, MAPT/TAU, GAP43 and NRGN/RC3 (By similarity) | 0.614 |
| FKBP9 | PPIC | ENSP00000242209 | ENSP00000303057 | FK506 binding protein 9, 63 kDa; PPIases accelerate the folding of proteins during protein synthesis | peptidylprolyl isomerase C (cyclophilin C); PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity) | 0.594 |
| FKBP9 | PRPF31 | ENSP00000242209 | ENSP00000324122 | FK506 binding protein 9, 63 kDa; PPIases accelerate the folding of proteins during protein synthesis | PRP31 pre-mRNA processing factor 31 homolog (S. cerevisiae) | 0.543 |
| FKBP9 | STK39 | ENSP00000242209 | ENSP00000348278 | FK506 binding protein 9, 63 kDa; PPIases accelerate the folding of proteins during protein synthesis | serine threonine kinase 39; May act as a mediator of stress-activated signals | 0.538 |
| FKBP9 | XPNPEP1 | ENSP00000242209 | ENSP00000421566 | FK506 binding protein 9, 63 kDa; PPIases accelerate the folding of proteins during protein synthesis | X-prolyl aminopeptidase (aminopeptidase P) 1, soluble; Contributes to the degradation of bradykinin. Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Arg-Pro-Pro | 0.586 |
| H2AFV | C9orf78 | ENSP00000308405 | ENSP00000361524 | H2A histone family, member V; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be [...] | chromosome 9 open reading frame 78 | 0.551 |
| H2AFV | FKBP9 | ENSP00000308405 | ENSP00000242209 | H2A histone family, member V; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be [...] | FK506 binding protein 9, 63 kDa; PPIases accelerate the folding of proteins during protein synthesis | 0.547 |
| H2AFV | HERC4 | ENSP00000308405 | ENSP00000378624 | H2A histone family, member V; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be [...] | HECT and RLD domain containing E3 ubiquitin protein ligase 4; Probable E3 ubiquitin-protein ligase involved in either protein trafficking or in the distribution of cellular structures. Required for spermatozoon maturation and fertility, and for the removal of the cytoplasmic droplet of the spermatozoon. E3 ubiquitin-protein ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfer it to targeted substrates (By similarity) | 0.615 |
| H2AFV | NUBP2 | ENSP00000308405 | ENSP00000262302 | H2A histone family, member V; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be [...] | nucleotide binding protein 2; Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins (By similarity) | 0.538 |
| H2AFV | XPNPEP1 | ENSP00000308405 | ENSP00000421566 | H2A histone family, member V; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be [...] | X-prolyl aminopeptidase (aminopeptidase P) 1, soluble; Contributes to the degradation of bradykinin. Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Arg-Pro-Pro | 0.461 |
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