RAMP3 protein (Homo sapiens) - STRING network view

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RAMP3

receptor (G protein-coupled) activity modifying protein 3; Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL (148 aa)

Predicted Functional Partners:

CALCRL

0.965

CALCR

0.893

GPER

0.835

LOXL2

0.823

PTH

0.822

SLC45A3

0.817

IAPP

0.815

KRT16

0.806

GRB10

0.804

TBX3

0.803

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CALCR	IAPP	ENSP00000352561	ENSP00000240652	calcitonin receptor; This is a receptor for calcitonin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The calcitonin receptor is thought to couple to the heterotrimeric guanosine triphosphate-binding protein that is sensitive to cholera toxin	islet amyloid polypeptide; Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism	0.974
CALCR	PTH	ENSP00000352561	ENSP00000282091	calcitonin receptor; This is a receptor for calcitonin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The calcitonin receptor is thought to couple to the heterotrimeric guanosine triphosphate-binding protein that is sensitive to cholera toxin	parathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2- deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells	0.968
CALCR	RAMP3	ENSP00000352561	ENSP00000242249	calcitonin receptor; This is a receptor for calcitonin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The calcitonin receptor is thought to couple to the heterotrimeric guanosine triphosphate-binding protein that is sensitive to cholera toxin	receptor (G protein-coupled) activity modifying protein 3; Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL	0.893
CALCRL	IAPP	ENSP00000376177	ENSP00000240652	calcitonin receptor-like; Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP3 (By similarity). Receptor for adrenomedullin together with RAMP2. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase	islet amyloid polypeptide; Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism	0.760
CALCRL	RAMP3	ENSP00000376177	ENSP00000242249	calcitonin receptor-like; Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP3 (By similarity). Receptor for adrenomedullin together with RAMP2. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase	receptor (G protein-coupled) activity modifying protein 3; Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL	0.965
GPER	RAMP3	ENSP00000297469	ENSP00000242249	G protein-coupled estrogen receptor 1	receptor (G protein-coupled) activity modifying protein 3; Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL	0.835
GRB10	KRT16	ENSP00000381793	ENSP00000301653	growth factor receptor-bound protein 10	keratin 16	0.803
GRB10	RAMP3	ENSP00000381793	ENSP00000242249	growth factor receptor-bound protein 10	receptor (G protein-coupled) activity modifying protein 3; Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL	0.804
GRB10	SLC45A3	ENSP00000381793	ENSP00000356113	growth factor receptor-bound protein 10	solute carrier family 45, member 3	0.800
GRB10	TBX3	ENSP00000381793	ENSP00000257566	growth factor receptor-bound protein 10	T-box 3; Transcriptional repressor involved in developmental processes. Probably plays a role in limb pattern formation. Acts as a negative regulator of PML function in cellular senescence	0.802
IAPP	CALCR	ENSP00000240652	ENSP00000352561	islet amyloid polypeptide; Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism	calcitonin receptor; This is a receptor for calcitonin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The calcitonin receptor is thought to couple to the heterotrimeric guanosine triphosphate-binding protein that is sensitive to cholera toxin	0.974
IAPP	CALCRL	ENSP00000240652	ENSP00000376177	islet amyloid polypeptide; Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism	calcitonin receptor-like; Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP3 (By similarity). Receptor for adrenomedullin together with RAMP2. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase	0.760
IAPP	PTH	ENSP00000240652	ENSP00000282091	islet amyloid polypeptide; Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism	parathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2- deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells	0.936
IAPP	RAMP3	ENSP00000240652	ENSP00000242249	islet amyloid polypeptide; Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism	receptor (G protein-coupled) activity modifying protein 3; Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL	0.815
KRT16	GRB10	ENSP00000301653	ENSP00000381793	keratin 16	growth factor receptor-bound protein 10	0.803
KRT16	RAMP3	ENSP00000301653	ENSP00000242249	keratin 16	receptor (G protein-coupled) activity modifying protein 3; Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL	0.806
KRT16	SLC45A3	ENSP00000301653	ENSP00000356113	keratin 16	solute carrier family 45, member 3	0.800
KRT16	TBX3	ENSP00000301653	ENSP00000257566	keratin 16	T-box 3; Transcriptional repressor involved in developmental processes. Probably plays a role in limb pattern formation. Acts as a negative regulator of PML function in cellular senescence	0.803
LOXL2	RAMP3	ENSP00000373783	ENSP00000242249	lysyl oxidase-like 2; Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine). When secreted in extracellular matrix, promotes cross-linking of extracellular matrix proteins by mediating oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Acts as a regulator of sprouting angiogenesis, probably via collagen IV scaffolding. When nuclear, acts as a transcription corepressor and specifically mediates deamination of trimethylated ’Lys-4’ of histone H3 (H3 [...]	receptor (G protein-coupled) activity modifying protein 3; Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL	0.823
PTH	CALCR	ENSP00000282091	ENSP00000352561	parathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2- deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells	calcitonin receptor; This is a receptor for calcitonin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The calcitonin receptor is thought to couple to the heterotrimeric guanosine triphosphate-binding protein that is sensitive to cholera toxin	0.968

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