Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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Neighborhood |
Gene Fusion |
Cooccurence |
Coexpression |
Experiments |
Databases |
Textmining |
[Homology] |
Score |
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 | DNAI1 | dynein, axonemal, intermediate chain 1; Part of the dynein complex of respiratory cilia (699 aa) | ||||||||||||
Predicted Functional Partners:
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 | DNAI2 | dynein, axonemal, intermediate chain 2; Part of the dynein complex of respiratory cilia (605 aa) |
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0.959 | |||||||
 | CCDC114 | coiled-coil domain containing 114; Probable component of the outer dynein arm complex required along the entire axoneme for tethering of outer dynein arms (Probable) (670 aa) |
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0.925 | |||||||
 | DNAH5 | dynein, axonemal, heavy chain 5; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Required for structural and functional integrity of the cilia of ependymal cells lining the brain ventricles (4624 aa) |
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0.894 | |||||||||
 | DNALI1 | dynein, axonemal, light intermediate chain 1; May play a dynamic role in flagellar motility (280 aa) |
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0.856 | ||||||||
 | DNAH11 | dynein, axonemal, heavy chain 11; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP (4523 aa) |
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0.855 | |||||||||
 | NME8 | NME/NM23 family member 8; Probably required during the final stages of sperm tail maturation in the testis and/or epididymis, where extensive disulfide bonding of fibrous sheath (FS) proteins occurs. May be involved in the reduction of disulfide bonds within the sperm FS components. In vitro, it has neither NDP kinase nor reducing activity on disulfide bonds (588 aa) |
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0.834 | ||||||||||
 | DNAH1 | dynein, axonemal, heavy chain 1 (4265 aa) |
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0.822 | ||||||||
 | DNAH9 | dynein, axonemal, heavy chain 9; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP (4486 aa) |
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0.801 | |||||||||
 | DNAH7 | dynein, axonemal, heavy chain 7 (4024 aa) |
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0.795 | ||||||||
 | RSPH4A | radial spoke head 4 homolog A (Chlamydomonas); Probable component of the axonemal radial spoke head. Radial spokes are regularly spaced along cilia, sperm and flagella axonemes. They consist of a thin stalk which is attached to a subfiber of the outer doublet microtubule, and a bulbous head which is attached to the stalk and appears to interact with the projections from the central pair of microtubules (716 aa) |
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0.768 | |||||||||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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