| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CIAPIN1 | KLHL24 | ENSP00000377914 | ENSP00000242810 | cytokine induced apoptosis inhibitor 1; May be required for the maturation of extramitochondrial Fe/S proteins (By similarity). Has anti-apoptotic effects in the cell. Involved in negative control of cell death upon cytokine withdrawal. Promotes development of hematopoietic cells (By similarity) | kelch-like 24 (Drosophila); Specifically reduces kainate receptor-mediated currents in hippocampal neurons, most probably by modulating channel properties (By similarity) | 0.705 |
| CIAPIN1 | UBC | ENSP00000377914 | ENSP00000344818 | cytokine induced apoptosis inhibitor 1; May be required for the maturation of extramitochondrial Fe/S proteins (By similarity). Has anti-apoptotic effects in the cell. Involved in negative control of cell death upon cytokine withdrawal. Promotes development of hematopoietic cells (By similarity) | ubiquitin C | 0.969 |
| COPS5 | COPS6 | ENSP00000350512 | ENSP00000304102 | COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis); Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via i [...] | COP9 constitutive photomorphogenic homolog subunit 6 (Arabidopsis); Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with [...] | 0.999 |
| COPS5 | KLHL24 | ENSP00000350512 | ENSP00000242810 | COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis); Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via i [...] | kelch-like 24 (Drosophila); Specifically reduces kainate receptor-mediated currents in hippocampal neurons, most probably by modulating channel properties (By similarity) | 0.896 |
| COPS5 | UBC | ENSP00000350512 | ENSP00000344818 | COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis); Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via i [...] | ubiquitin C | 0.995 |
| COPS6 | COPS5 | ENSP00000304102 | ENSP00000350512 | COP9 constitutive photomorphogenic homolog subunit 6 (Arabidopsis); Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with [...] | COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis); Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via i [...] | 0.999 |
| COPS6 | KLHL24 | ENSP00000304102 | ENSP00000242810 | COP9 constitutive photomorphogenic homolog subunit 6 (Arabidopsis); Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with [...] | kelch-like 24 (Drosophila); Specifically reduces kainate receptor-mediated currents in hippocampal neurons, most probably by modulating channel properties (By similarity) | 0.891 |
| COPS6 | UBC | ENSP00000304102 | ENSP00000344818 | COP9 constitutive photomorphogenic homolog subunit 6 (Arabidopsis); Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with [...] | ubiquitin C | 0.973 |
| EFCAB13 | KLHL24 | ENSP00000332111 | ENSP00000242810 | EF-hand calcium binding domain 13 | kelch-like 24 (Drosophila); Specifically reduces kainate receptor-mediated currents in hippocampal neurons, most probably by modulating channel properties (By similarity) | 0.547 |
| GRIK2 | KLHL24 | ENSP00000397026 | ENSP00000242810 | glutamate receptor, ionotropic, kainate 2 | kelch-like 24 (Drosophila); Specifically reduces kainate receptor-mediated currents in hippocampal neurons, most probably by modulating channel properties (By similarity) | 0.722 |
| GRIK2 | PICK1 | ENSP00000397026 | ENSP00000349465 | glutamate receptor, ionotropic, kainate 2 | protein interacting with PRKCA 1; Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate heteromeric ASIC1/ASIC3 channel | 0.943 |
| HECW1 | KLHL24 | ENSP00000379228 | ENSP00000242810 | HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent degradation of DVL1. Also targets the mutant SOD1 protein involved in familial amyotrophic lateral sclerosis (FALS). Forms cytotoxic aggregates with DVL1, SSR3 and mutant SOD1 that lead to motor neuron death in FALS | kelch-like 24 (Drosophila); Specifically reduces kainate receptor-mediated currents in hippocampal neurons, most probably by modulating channel properties (By similarity) | 0.405 |
| HECW1 | UBC | ENSP00000379228 | ENSP00000344818 | HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent degradation of DVL1. Also targets the mutant SOD1 protein involved in familial amyotrophic lateral sclerosis (FALS). Forms cytotoxic aggregates with DVL1, SSR3 and mutant SOD1 that lead to motor neuron death in FALS | ubiquitin C | 0.981 |
| HECW2 | KLHL24 | ENSP00000260983 | ENSP00000242810 | HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2; E3 ubiquitin-protein ligase that mediates ubiquitination of TP73. Acts to stabilize TP73 and enhance activation of transcription by TP73 | kelch-like 24 (Drosophila); Specifically reduces kainate receptor-mediated currents in hippocampal neurons, most probably by modulating channel properties (By similarity) | 0.448 |
| HECW2 | UBC | ENSP00000260983 | ENSP00000344818 | HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2; E3 ubiquitin-protein ligase that mediates ubiquitination of TP73. Acts to stabilize TP73 and enhance activation of transcription by TP73 | ubiquitin C | 0.839 |
| KLHL24 | CIAPIN1 | ENSP00000242810 | ENSP00000377914 | kelch-like 24 (Drosophila); Specifically reduces kainate receptor-mediated currents in hippocampal neurons, most probably by modulating channel properties (By similarity) | cytokine induced apoptosis inhibitor 1; May be required for the maturation of extramitochondrial Fe/S proteins (By similarity). Has anti-apoptotic effects in the cell. Involved in negative control of cell death upon cytokine withdrawal. Promotes development of hematopoietic cells (By similarity) | 0.705 |
| KLHL24 | COPS5 | ENSP00000242810 | ENSP00000350512 | kelch-like 24 (Drosophila); Specifically reduces kainate receptor-mediated currents in hippocampal neurons, most probably by modulating channel properties (By similarity) | COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis); Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via i [...] | 0.896 |
| KLHL24 | COPS6 | ENSP00000242810 | ENSP00000304102 | kelch-like 24 (Drosophila); Specifically reduces kainate receptor-mediated currents in hippocampal neurons, most probably by modulating channel properties (By similarity) | COP9 constitutive photomorphogenic homolog subunit 6 (Arabidopsis); Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with [...] | 0.891 |
| KLHL24 | EFCAB13 | ENSP00000242810 | ENSP00000332111 | kelch-like 24 (Drosophila); Specifically reduces kainate receptor-mediated currents in hippocampal neurons, most probably by modulating channel properties (By similarity) | EF-hand calcium binding domain 13 | 0.547 |
| KLHL24 | GRIK2 | ENSP00000242810 | ENSP00000397026 | kelch-like 24 (Drosophila); Specifically reduces kainate receptor-mediated currents in hippocampal neurons, most probably by modulating channel properties (By similarity) | glutamate receptor, ionotropic, kainate 2 | 0.722 |
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