| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ASCL1 | CRX | ENSP00000266744 | ENSP00000221996 | achaete-scute complex homolog 1 (Drosophila); Transcriptional regulator. May play a role at early stages of development of specific neural lineages in most regions of the CNS, and of several lineages in the PNS. Essential for the generation of olfactory and autonomic neurons. Involved in the initiation of neuronal differentiation. Mediates transcription activation by binding to the E box (5’-CANNTG-3’) | cone-rod homeobox; Binds and transactivates the sequence 5’-TAATC[CA]-3’ which is found upstream of several photoreceptor-specific genes, including the opsin genes. Acts synergistically with other transcription factors, e.g. NRL and RX, to regulate photoreceptor cell-specific gene transcription. Essential for the maintenance of mammalian photoreceptors | 0.410 |
| ASCL1 | FOXN4 | ENSP00000266744 | ENSP00000299162 | achaete-scute complex homolog 1 (Drosophila); Transcriptional regulator. May play a role at early stages of development of specific neural lineages in most regions of the CNS, and of several lineages in the PNS. Essential for the generation of olfactory and autonomic neurons. Involved in the initiation of neuronal differentiation. Mediates transcription activation by binding to the E box (5’-CANNTG-3’) | forkhead box N4 | 0.902 |
| ASCL1 | HOXA2 | ENSP00000266744 | ENSP00000222718 | achaete-scute complex homolog 1 (Drosophila); Transcriptional regulator. May play a role at early stages of development of specific neural lineages in most regions of the CNS, and of several lineages in the PNS. Essential for the generation of olfactory and autonomic neurons. Involved in the initiation of neuronal differentiation. Mediates transcription activation by binding to the E box (5’-CANNTG-3’) | homeobox A2; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis | 0.483 |
| ASCL1 | HOXB2 | ENSP00000266744 | ENSP00000331741 | achaete-scute complex homolog 1 (Drosophila); Transcriptional regulator. May play a role at early stages of development of specific neural lineages in most regions of the CNS, and of several lineages in the PNS. Essential for the generation of olfactory and autonomic neurons. Involved in the initiation of neuronal differentiation. Mediates transcription activation by binding to the E box (5’-CANNTG-3’) | homeobox B2; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis | 0.512 |
| ASCL1 | LHX3 | ENSP00000266744 | ENSP00000360811 | achaete-scute complex homolog 1 (Drosophila); Transcriptional regulator. May play a role at early stages of development of specific neural lineages in most regions of the CNS, and of several lineages in the PNS. Essential for the generation of olfactory and autonomic neurons. Involved in the initiation of neuronal differentiation. Mediates transcription activation by binding to the E box (5’-CANNTG-3’) | LIM homeobox 3; Acts as a transcriptional activator. Binds to and activates the promoter of the alpha-glycoprotein gene, and synergistically enhances transcription from the prolactin promoter in cooperation with POU1F1/Pit-1 (By similarity). Required for the establishment of the specialized cells of the pituitary gland and the nervous system. Involved in the development of interneurons and motor neurons in cooperation with LDB1 and ISL1 | 0.492 |
| ASCL1 | NEUROD4 | ENSP00000266744 | ENSP00000242994 | achaete-scute complex homolog 1 (Drosophila); Transcriptional regulator. May play a role at early stages of development of specific neural lineages in most regions of the CNS, and of several lineages in the PNS. Essential for the generation of olfactory and autonomic neurons. Involved in the initiation of neuronal differentiation. Mediates transcription activation by binding to the E box (5’-CANNTG-3’) | neuronal differentiation 4; Probably acts as a transcriptional activator. Mediates neuronal differentiation. Required for the regulation of amacrine cell fate specification in the retina (By similarity) | 0.722 |
| ASCL1 | PAX6 | ENSP00000266744 | ENSP00000368401 | achaete-scute complex homolog 1 (Drosophila); Transcriptional regulator. May play a role at early stages of development of specific neural lineages in most regions of the CNS, and of several lineages in the PNS. Essential for the generation of olfactory and autonomic neurons. Involved in the initiation of neuronal differentiation. Mediates transcription activation by binding to the E box (5’-CANNTG-3’) | paired box 6; Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells (By similarity). Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity). Isoform 5a appears to function as a molecular switch that specifies target genes | 0.775 |
| ASCL1 | PHOX2B | ENSP00000266744 | ENSP00000226382 | achaete-scute complex homolog 1 (Drosophila); Transcriptional regulator. May play a role at early stages of development of specific neural lineages in most regions of the CNS, and of several lineages in the PNS. Essential for the generation of olfactory and autonomic neurons. Involved in the initiation of neuronal differentiation. Mediates transcription activation by binding to the E box (5’-CANNTG-3’) | paired-like homeobox 2b; Involved in the development of several major noradrenergic neuron populations, including the locus coeruleus. Transcription factor which could determine a neurotransmitter phenotype in vertebrates. Enhances second-messenger-mediated activation of the dopamine beta-hydrolase and c-fos promoters, and of several enhancers including cAMP-response element and serum- response element | 0.939 |
| ASCL1 | POU4F2 | ENSP00000266744 | ENSP00000281321 | achaete-scute complex homolog 1 (Drosophila); Transcriptional regulator. May play a role at early stages of development of specific neural lineages in most regions of the CNS, and of several lineages in the PNS. Essential for the generation of olfactory and autonomic neurons. Involved in the initiation of neuronal differentiation. Mediates transcription activation by binding to the E box (5’-CANNTG-3’) | POU class 4 homeobox 2; Transcription factor. May play a role in determining or maintaining the identities of a small subset of visual system neurons | 0.458 |
| ASCL1 | VSX2 | ENSP00000266744 | ENSP00000261980 | achaete-scute complex homolog 1 (Drosophila); Transcriptional regulator. May play a role at early stages of development of specific neural lineages in most regions of the CNS, and of several lineages in the PNS. Essential for the generation of olfactory and autonomic neurons. Involved in the initiation of neuronal differentiation. Mediates transcription activation by binding to the E box (5’-CANNTG-3’) | visual system homeobox 2; Plays a significant role in the specification and morphogenesis of the sensory retina. May also participate in the development of the cells of the inner nuclear layer, particularly bipolar cells (By similarity) | 0.910 |
| CRX | ASCL1 | ENSP00000221996 | ENSP00000266744 | cone-rod homeobox; Binds and transactivates the sequence 5’-TAATC[CA]-3’ which is found upstream of several photoreceptor-specific genes, including the opsin genes. Acts synergistically with other transcription factors, e.g. NRL and RX, to regulate photoreceptor cell-specific gene transcription. Essential for the maintenance of mammalian photoreceptors | achaete-scute complex homolog 1 (Drosophila); Transcriptional regulator. May play a role at early stages of development of specific neural lineages in most regions of the CNS, and of several lineages in the PNS. Essential for the generation of olfactory and autonomic neurons. Involved in the initiation of neuronal differentiation. Mediates transcription activation by binding to the E box (5’-CANNTG-3’) | 0.410 |
| CRX | FOXN4 | ENSP00000221996 | ENSP00000299162 | cone-rod homeobox; Binds and transactivates the sequence 5’-TAATC[CA]-3’ which is found upstream of several photoreceptor-specific genes, including the opsin genes. Acts synergistically with other transcription factors, e.g. NRL and RX, to regulate photoreceptor cell-specific gene transcription. Essential for the maintenance of mammalian photoreceptors | forkhead box N4 | 0.493 |
| CRX | NEUROD4 | ENSP00000221996 | ENSP00000242994 | cone-rod homeobox; Binds and transactivates the sequence 5’-TAATC[CA]-3’ which is found upstream of several photoreceptor-specific genes, including the opsin genes. Acts synergistically with other transcription factors, e.g. NRL and RX, to regulate photoreceptor cell-specific gene transcription. Essential for the maintenance of mammalian photoreceptors | neuronal differentiation 4; Probably acts as a transcriptional activator. Mediates neuronal differentiation. Required for the regulation of amacrine cell fate specification in the retina (By similarity) | 0.608 |
| CRX | POU4F2 | ENSP00000221996 | ENSP00000281321 | cone-rod homeobox; Binds and transactivates the sequence 5’-TAATC[CA]-3’ which is found upstream of several photoreceptor-specific genes, including the opsin genes. Acts synergistically with other transcription factors, e.g. NRL and RX, to regulate photoreceptor cell-specific gene transcription. Essential for the maintenance of mammalian photoreceptors | POU class 4 homeobox 2; Transcription factor. May play a role in determining or maintaining the identities of a small subset of visual system neurons | 0.592 |
| FOXN4 | ASCL1 | ENSP00000299162 | ENSP00000266744 | forkhead box N4 | achaete-scute complex homolog 1 (Drosophila); Transcriptional regulator. May play a role at early stages of development of specific neural lineages in most regions of the CNS, and of several lineages in the PNS. Essential for the generation of olfactory and autonomic neurons. Involved in the initiation of neuronal differentiation. Mediates transcription activation by binding to the E box (5’-CANNTG-3’) | 0.902 |
| FOXN4 | CRX | ENSP00000299162 | ENSP00000221996 | forkhead box N4 | cone-rod homeobox; Binds and transactivates the sequence 5’-TAATC[CA]-3’ which is found upstream of several photoreceptor-specific genes, including the opsin genes. Acts synergistically with other transcription factors, e.g. NRL and RX, to regulate photoreceptor cell-specific gene transcription. Essential for the maintenance of mammalian photoreceptors | 0.493 |
| FOXN4 | LHX3 | ENSP00000299162 | ENSP00000360811 | forkhead box N4 | LIM homeobox 3; Acts as a transcriptional activator. Binds to and activates the promoter of the alpha-glycoprotein gene, and synergistically enhances transcription from the prolactin promoter in cooperation with POU1F1/Pit-1 (By similarity). Required for the establishment of the specialized cells of the pituitary gland and the nervous system. Involved in the development of interneurons and motor neurons in cooperation with LDB1 and ISL1 | 0.437 |
| FOXN4 | NEUROD4 | ENSP00000299162 | ENSP00000242994 | forkhead box N4 | neuronal differentiation 4; Probably acts as a transcriptional activator. Mediates neuronal differentiation. Required for the regulation of amacrine cell fate specification in the retina (By similarity) | 0.860 |
| FOXN4 | PAX6 | ENSP00000299162 | ENSP00000368401 | forkhead box N4 | paired box 6; Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells (By similarity). Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity). Isoform 5a appears to function as a molecular switch that specifies target genes | 0.515 |
| FOXN4 | POU4F2 | ENSP00000299162 | ENSP00000281321 | forkhead box N4 | POU class 4 homeobox 2; Transcription factor. May play a role in determining or maintaining the identities of a small subset of visual system neurons | 0.499 |
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