node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DLX1 | HOXC13 | ENSP00000354478 | ENSP00000243056 | distal-less homeobox 1; Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis and may be involved in the early development of diencephalic subdivisions (By similarity) | homeobox C13; Transcription factor which plays a role in hair follicle differentiation. Regulates FOXQ1 expression and that of other hair-specific genes (By similarity) | 0.713 |
DLX1 | MEIS1 | ENSP00000354478 | ENSP00000272369 | distal-less homeobox 1; Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis and may be involved in the early development of diencephalic subdivisions (By similarity) | Meis homeobox 1; Acts as a transcriptional regulator of PAX6. Acts as a transcriptional activator of PF4 in complex with PBX1 or PBX2. Required for hematopoiesis, megakaryocyte lineage development and vascular patterning. May function as a cofactor for HOXA7 and HOXA9 in the induction of myeloid leukemias | 0.514 |
DLX3 | HOXC13 | ENSP00000389870 | ENSP00000243056 | distal-less homeobox 3; Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis | homeobox C13; Transcription factor which plays a role in hair follicle differentiation. Regulates FOXQ1 expression and that of other hair-specific genes (By similarity) | 0.822 |
DLX4 | HOXC13 | ENSP00000240306 | ENSP00000243056 | distal-less homeobox 4; May play a role in determining the production of hemoglobin S. May act as a repressor | homeobox C13; Transcription factor which plays a role in hair follicle differentiation. Regulates FOXQ1 expression and that of other hair-specific genes (By similarity) | 0.719 |
DLX6 | HOXC13 | ENSP00000428480 | ENSP00000243056 | distal-less homeobox 6 | homeobox C13; Transcription factor which plays a role in hair follicle differentiation. Regulates FOXQ1 expression and that of other hair-specific genes (By similarity) | 0.714 |
FOXQ1 | HOXC13 | ENSP00000296839 | ENSP00000243056 | forkhead box Q1; Plays a role in hair follicle differentiation (By similarity) | homeobox C13; Transcription factor which plays a role in hair follicle differentiation. Regulates FOXQ1 expression and that of other hair-specific genes (By similarity) | 0.945 |
HOXC13 | DLX1 | ENSP00000243056 | ENSP00000354478 | homeobox C13; Transcription factor which plays a role in hair follicle differentiation. Regulates FOXQ1 expression and that of other hair-specific genes (By similarity) | distal-less homeobox 1; Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis and may be involved in the early development of diencephalic subdivisions (By similarity) | 0.713 |
HOXC13 | DLX3 | ENSP00000243056 | ENSP00000389870 | homeobox C13; Transcription factor which plays a role in hair follicle differentiation. Regulates FOXQ1 expression and that of other hair-specific genes (By similarity) | distal-less homeobox 3; Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis | 0.822 |
HOXC13 | DLX4 | ENSP00000243056 | ENSP00000240306 | homeobox C13; Transcription factor which plays a role in hair follicle differentiation. Regulates FOXQ1 expression and that of other hair-specific genes (By similarity) | distal-less homeobox 4; May play a role in determining the production of hemoglobin S. May act as a repressor | 0.719 |
HOXC13 | DLX6 | ENSP00000243056 | ENSP00000428480 | homeobox C13; Transcription factor which plays a role in hair follicle differentiation. Regulates FOXQ1 expression and that of other hair-specific genes (By similarity) | distal-less homeobox 6 | 0.714 |
HOXC13 | FOXQ1 | ENSP00000243056 | ENSP00000296839 | homeobox C13; Transcription factor which plays a role in hair follicle differentiation. Regulates FOXQ1 expression and that of other hair-specific genes (By similarity) | forkhead box Q1; Plays a role in hair follicle differentiation (By similarity) | 0.945 |
HOXC13 | INTS12 | ENSP00000243056 | ENSP00000340737 | homeobox C13; Transcription factor which plays a role in hair follicle differentiation. Regulates FOXQ1 expression and that of other hair-specific genes (By similarity) | integrator complex subunit 12; Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3’-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes | 0.708 |
HOXC13 | MEIS1 | ENSP00000243056 | ENSP00000272369 | homeobox C13; Transcription factor which plays a role in hair follicle differentiation. Regulates FOXQ1 expression and that of other hair-specific genes (By similarity) | Meis homeobox 1; Acts as a transcriptional regulator of PAX6. Acts as a transcriptional activator of PF4 in complex with PBX1 or PBX2. Required for hematopoiesis, megakaryocyte lineage development and vascular patterning. May function as a cofactor for HOXA7 and HOXA9 in the induction of myeloid leukemias | 0.725 |
HOXC13 | MTF2 | ENSP00000243056 | ENSP00000359321 | homeobox C13; Transcription factor which plays a role in hair follicle differentiation. Regulates FOXQ1 expression and that of other hair-specific genes (By similarity) | metal response element binding transcription factor 2; Polycomb group (PcG) that specifically binds histone H3 trimethylated at ’Lys-36’ (H3K36me3) and recruits the PRC2 complex. Acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting the PRC2 complex, leading to enhance PRC2 H3K27me3 methylation activity. Regulates the transcriptional networks during embryonic stem cell self-renewal and differentiation. Promotes recruitment of the PRC2 complex to the inactive X chromosome in differentiating XX ES cells and PRC2 recruitment to target genes in undifferentiated [...] | 0.708 |
HOXC13 | PHF1 | ENSP00000243056 | ENSP00000363640 | homeobox C13; Transcription factor which plays a role in hair follicle differentiation. Regulates FOXQ1 expression and that of other hair-specific genes (By similarity) | PHD finger protein 1; Polycomb group (PcG) that specifically binds histone H3 trimethylated at ’Lys-36’ (H3K36me3) and recruits the PRC2 complex. Involved in DNA damage response and is recruited at double-strand breaks (DSBs). Acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting the PRC2 complex- it is however unclear whether recruitment of the PRC2 complex to H3K36me3 leads to enhance or inhibit H3K27me3 methylation mediated by the PRC2 complex. According to some reports, PRC2 recruitment by PHF1 promotes H3K27me3 and subsequent gene silencing by inducing [...] | 0.708 |
HOXC13 | PHF19 | ENSP00000243056 | ENSP00000363003 | homeobox C13; Transcription factor which plays a role in hair follicle differentiation. Regulates FOXQ1 expression and that of other hair-specific genes (By similarity) | PHD finger protein 19; Polycomb group (PcG) that specifically binds histone H3 trimethylated at ’Lys-36’ (H3K36me3) and recruits the PRC2 complex. Probably involved in the transition from an active state to a repressed state in embryonic stem cells- acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting H3K36me3 histone demethylases NO66 or KDM2B, leading to demethylation of H3K36 and recruitment of the PRC2 complex that mediates H3K27me3 methylation, followed by de novo silencing. Recruits the PRC2 complex to CpG islands and contributes to embryonic stem ce [...] | 0.708 |
INTS12 | HOXC13 | ENSP00000340737 | ENSP00000243056 | integrator complex subunit 12; Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3’-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes | homeobox C13; Transcription factor which plays a role in hair follicle differentiation. Regulates FOXQ1 expression and that of other hair-specific genes (By similarity) | 0.708 |
MEIS1 | DLX1 | ENSP00000272369 | ENSP00000354478 | Meis homeobox 1; Acts as a transcriptional regulator of PAX6. Acts as a transcriptional activator of PF4 in complex with PBX1 or PBX2. Required for hematopoiesis, megakaryocyte lineage development and vascular patterning. May function as a cofactor for HOXA7 and HOXA9 in the induction of myeloid leukemias | distal-less homeobox 1; Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis and may be involved in the early development of diencephalic subdivisions (By similarity) | 0.514 |
MEIS1 | HOXC13 | ENSP00000272369 | ENSP00000243056 | Meis homeobox 1; Acts as a transcriptional regulator of PAX6. Acts as a transcriptional activator of PF4 in complex with PBX1 or PBX2. Required for hematopoiesis, megakaryocyte lineage development and vascular patterning. May function as a cofactor for HOXA7 and HOXA9 in the induction of myeloid leukemias | homeobox C13; Transcription factor which plays a role in hair follicle differentiation. Regulates FOXQ1 expression and that of other hair-specific genes (By similarity) | 0.725 |
MTF2 | HOXC13 | ENSP00000359321 | ENSP00000243056 | metal response element binding transcription factor 2; Polycomb group (PcG) that specifically binds histone H3 trimethylated at ’Lys-36’ (H3K36me3) and recruits the PRC2 complex. Acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting the PRC2 complex, leading to enhance PRC2 H3K27me3 methylation activity. Regulates the transcriptional networks during embryonic stem cell self-renewal and differentiation. Promotes recruitment of the PRC2 complex to the inactive X chromosome in differentiating XX ES cells and PRC2 recruitment to target genes in undifferentiated [...] | homeobox C13; Transcription factor which plays a role in hair follicle differentiation. Regulates FOXQ1 expression and that of other hair-specific genes (By similarity) | 0.708 |