| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| HAS2 | TNFAIP6 | ENSP00000306991 | ENSP00000243347 | hyaluronan synthase 2; Plays a role in hyaluronan/hyaluronic acid (HA) synthesis | tumor necrosis factor, alpha-induced protein 6; Possibly involved in cell-cell and cell-matrix interactions during inflammation and tumorigenesis | 0.751 |
| IL17A | IL1B | ENSP00000344192 | ENSP00000263341 | interleukin 17A; Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of ICAM1/intracellular adhesion molecule 1 in fibroblasts | interleukin 1, beta; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells | 0.928 |
| IL17A | MMP1 | ENSP00000344192 | ENSP00000322788 | interleukin 17A; Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of ICAM1/intracellular adhesion molecule 1 in fibroblasts | matrix metallopeptidase 1 (interstitial collagenase); Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X. In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat’s mediated neurotoxicity | 0.878 |
| IL17A | TNF | ENSP00000344192 | ENSP00000398698 | interleukin 17A; Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of ICAM1/intracellular adhesion molecule 1 in fibroblasts | tumor necrosis factor | 0.623 |
| IL17A | TNFAIP6 | ENSP00000344192 | ENSP00000243347 | interleukin 17A; Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of ICAM1/intracellular adhesion molecule 1 in fibroblasts | tumor necrosis factor, alpha-induced protein 6; Possibly involved in cell-cell and cell-matrix interactions during inflammation and tumorigenesis | 0.840 |
| IL1B | IL17A | ENSP00000263341 | ENSP00000344192 | interleukin 1, beta; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells | interleukin 17A; Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of ICAM1/intracellular adhesion molecule 1 in fibroblasts | 0.928 |
| IL1B | MMP1 | ENSP00000263341 | ENSP00000322788 | interleukin 1, beta; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells | matrix metallopeptidase 1 (interstitial collagenase); Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X. In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat’s mediated neurotoxicity | 0.928 |
| IL1B | MMP13 | ENSP00000263341 | ENSP00000260302 | interleukin 1, beta; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells | matrix metallopeptidase 13 (collagenase 3); Degrades collagen type I. Does not act on gelatin or casein. Could have a role in tumoral process | 0.909 |
| IL1B | TNF | ENSP00000263341 | ENSP00000398698 | interleukin 1, beta; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells | tumor necrosis factor | 0.968 |
| IL1B | TNFAIP6 | ENSP00000263341 | ENSP00000243347 | interleukin 1, beta; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells | tumor necrosis factor, alpha-induced protein 6; Possibly involved in cell-cell and cell-matrix interactions during inflammation and tumorigenesis | 0.862 |
| LRCH1 | TM2D3 | ENSP00000374447 | ENSP00000330433 | leucine-rich repeats and calponin homology (CH) domain containing 1 | TM2 domain containing 3 | 0.685 |
| LRCH1 | TNFAIP6 | ENSP00000374447 | ENSP00000243347 | leucine-rich repeats and calponin homology (CH) domain containing 1 | tumor necrosis factor, alpha-induced protein 6; Possibly involved in cell-cell and cell-matrix interactions during inflammation and tumorigenesis | 0.683 |
| MMP1 | IL17A | ENSP00000322788 | ENSP00000344192 | matrix metallopeptidase 1 (interstitial collagenase); Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X. In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat’s mediated neurotoxicity | interleukin 17A; Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of ICAM1/intracellular adhesion molecule 1 in fibroblasts | 0.878 |
| MMP1 | IL1B | ENSP00000322788 | ENSP00000263341 | matrix metallopeptidase 1 (interstitial collagenase); Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X. In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat’s mediated neurotoxicity | interleukin 1, beta; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells | 0.928 |
| MMP1 | THBS1 | ENSP00000322788 | ENSP00000260356 | matrix metallopeptidase 1 (interstitial collagenase); Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X. In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat’s mediated neurotoxicity | thrombospondin 1; Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Binds heparin. May play a role in dentinogenesis and/or maintenance of dentin and dental pulp (By similarity). Ligand for CD36 mediating antiangiogenic properties | 0.553 |
| MMP1 | TNF | ENSP00000322788 | ENSP00000398698 | matrix metallopeptidase 1 (interstitial collagenase); Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X. In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat’s mediated neurotoxicity | tumor necrosis factor | 0.710 |
| MMP1 | TNFAIP6 | ENSP00000322788 | ENSP00000243347 | matrix metallopeptidase 1 (interstitial collagenase); Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X. In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat’s mediated neurotoxicity | tumor necrosis factor, alpha-induced protein 6; Possibly involved in cell-cell and cell-matrix interactions during inflammation and tumorigenesis | 0.846 |
| MMP13 | IL1B | ENSP00000260302 | ENSP00000263341 | matrix metallopeptidase 13 (collagenase 3); Degrades collagen type I. Does not act on gelatin or casein. Could have a role in tumoral process | interleukin 1, beta; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells | 0.909 |
| MMP13 | TNF | ENSP00000260302 | ENSP00000398698 | matrix metallopeptidase 13 (collagenase 3); Degrades collagen type I. Does not act on gelatin or casein. Could have a role in tumoral process | tumor necrosis factor | 0.864 |
| MMP13 | TNFAIP6 | ENSP00000260302 | ENSP00000243347 | matrix metallopeptidase 13 (collagenase 3); Degrades collagen type I. Does not act on gelatin or casein. Could have a role in tumoral process | tumor necrosis factor, alpha-induced protein 6; Possibly involved in cell-cell and cell-matrix interactions during inflammation and tumorigenesis | 0.799 |
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