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PRKACB PRKACB CFC1 CFC1 ACVR1C ACVR1C NODAL NODAL INHBB INHBB TDGF1 TDGF1 ACVR2B ACVR2B ACVR2A ACVR2A SMAD2 SMAD2 SMAD7 SMAD7 SMAD3 SMAD3
"ACVR1C" - activin A receptor, type IC in Homo sapiens
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ACVR1Cactivin A receptor, type IC; Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis (493 aa)    
Predicted Functional Partners:
SMAD2
SMAD family member 2; Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator (467 aa)
        score_image score_image score_image   0.998
SMAD3
SMAD family member 3 (425 aa)
        score_image score_image score_image   0.989
TDGF1
teratocarcinoma-derived growth factor 1; Could play a role in the determination of the epiblastic cells that subsequently give rise to the mesoderm. Activates the Nodal-dependent signaling pathway (188 aa)
        score_image score_image score_image   0.988
INHBB
inhibin, beta B; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins (407 aa)
        score_image   score_image   0.964
NODAL
nodal homolog (mouse); Essential for mesoderm formation and axial patterning during embryonic development (By similarity) (347 aa)
        score_image score_image score_image   0.959
SMAD7
SMAD family member 7; Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access. Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A- PP1 complex to TGFBR1, which promotes its dephosphorylation. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator ( [...] (426 aa)
        score_image   score_image   0.953
ACVR2A
activin A receptor, type IIA; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A (513 aa)
      score_image score_image score_image score_image score_image 0.943
ACVR2B
activin A receptor, type IIB; Transmembrane serine/threonine kinase activin type-2 receptor forming an activin receptor complex with activin type-1 serine/threonine kinase receptors (ACVR1, ACVR1B or ACVR1c). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought [...] (512 aa)
      score_image score_image score_image score_image score_image 0.943
CFC1
cripto, FRL-1, cryptic family 1; NODAL coreceptor involved in the correct establishment of the left-right axis. May play a role in mesoderm and/or neural patterning during gastrulation (223 aa)
          score_image score_image   0.930
PRKACB
protein kinase, cAMP-dependent, catalytic, beta (398 aa)
          score_image score_image   0.908
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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