node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACVR2A | FST | ENSP00000241416 | ENSP00000256759 | activin A receptor, type IIA; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A | follistatin; Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH) | 0.819 |
ACVR2A | INHA | ENSP00000241416 | ENSP00000243786 | activin A receptor, type IIA; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A | inhibin, alpha; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins | 0.945 |
ACVR2A | INHBA | ENSP00000241416 | ENSP00000242208 | activin A receptor, type IIA; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A | inhibin, beta A; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins | 0.999 |
ACVR2A | INHBB | ENSP00000241416 | ENSP00000295228 | activin A receptor, type IIA; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A | inhibin, beta B; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins | 0.984 |
ACVR2A | INHBC | ENSP00000241416 | ENSP00000308716 | activin A receptor, type IIA; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A | inhibin, beta C; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins | 0.948 |
ACVR2A | INHBE | ENSP00000241416 | ENSP00000266646 | activin A receptor, type IIA; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A | inhibin, beta E; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins | 0.861 |
ACVR2A | TGFBR3 | ENSP00000241416 | ENSP00000212355 | activin A receptor, type IIA; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A | transforming growth factor, beta receptor III; Binds to TGF-beta. Could be involved in capturing and retaining TGF-beta for presentation to the signaling receptors | 0.926 |
CGA | FSHB | ENSP00000358595 | ENSP00000254122 | glycoprotein hormones, alpha polypeptide | follicle stimulating hormone, beta polypeptide; Stimulates development of follicle and spermatogenesis in the reproductive organs | 0.999 |
CGA | INHA | ENSP00000358595 | ENSP00000243786 | glycoprotein hormones, alpha polypeptide | inhibin, alpha; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins | 0.906 |
CGA | INHBA | ENSP00000358595 | ENSP00000242208 | glycoprotein hormones, alpha polypeptide | inhibin, beta A; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins | 0.908 |
CGA | INHBB | ENSP00000358595 | ENSP00000295228 | glycoprotein hormones, alpha polypeptide | inhibin, beta B; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins | 0.903 |
CGA | INHBC | ENSP00000358595 | ENSP00000308716 | glycoprotein hormones, alpha polypeptide | inhibin, beta C; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins | 0.900 |
CGA | INHBE | ENSP00000358595 | ENSP00000266646 | glycoprotein hormones, alpha polypeptide | inhibin, beta E; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins | 0.900 |
FSHB | CGA | ENSP00000254122 | ENSP00000358595 | follicle stimulating hormone, beta polypeptide; Stimulates development of follicle and spermatogenesis in the reproductive organs | glycoprotein hormones, alpha polypeptide | 0.999 |
FSHB | FST | ENSP00000254122 | ENSP00000256759 | follicle stimulating hormone, beta polypeptide; Stimulates development of follicle and spermatogenesis in the reproductive organs | follistatin; Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH) | 0.581 |
FSHB | INHA | ENSP00000254122 | ENSP00000243786 | follicle stimulating hormone, beta polypeptide; Stimulates development of follicle and spermatogenesis in the reproductive organs | inhibin, alpha; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins | 0.920 |
FSHB | INHBA | ENSP00000254122 | ENSP00000242208 | follicle stimulating hormone, beta polypeptide; Stimulates development of follicle and spermatogenesis in the reproductive organs | inhibin, beta A; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins | 0.929 |
FSHB | INHBB | ENSP00000254122 | ENSP00000295228 | follicle stimulating hormone, beta polypeptide; Stimulates development of follicle and spermatogenesis in the reproductive organs | inhibin, beta B; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins | 0.930 |
FSHB | INHBC | ENSP00000254122 | ENSP00000308716 | follicle stimulating hormone, beta polypeptide; Stimulates development of follicle and spermatogenesis in the reproductive organs | inhibin, beta C; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins | 0.901 |
FSHB | INHBE | ENSP00000254122 | ENSP00000266646 | follicle stimulating hormone, beta polypeptide; Stimulates development of follicle and spermatogenesis in the reproductive organs | inhibin, beta E; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins | 0.900 |