MC3R protein (Homo sapiens) - STRING network view

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MC3R

melanocortin 3 receptor; Receptor for MSH (alpha, beta and gamma) and ACTH. This receptor is mediated by G proteins which activate adenylate cyclase (323 aa)

Predicted Functional Partners:

POMC

0.991

AGRP

0.988

NPS

0.968

CRH

0.948

GCG

0.935

GLP1R

0.927

GHRH

0.925

CRHR2

0.920

AVP

0.920

GNAS

0.919

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGRP	AVP	ENSP00000290953	ENSP00000369647	agouti related protein homolog (mouse); Plays a role in weight homeostasis. Involved in the control of feeding behavior through the central melanocortin system. Acts as alpha melanocyte-stimulating hormone antagonist by inhibiting cAMP production mediated by stimulation of melanocortin receptors within the hypothalamus and adrenal gland. Has very low activity with MC5R (By similarity). Is an inverse agonist for MC3R and MC4R being able to suppress their constitutive activity. It promotes MC3R and MC4R endocytosis in an arrestin-dependent manner	arginine vasopressin; Neurophysin 2 specifically binds vasopressin	0.414
AGRP	CRH	ENSP00000290953	ENSP00000276571	agouti related protein homolog (mouse); Plays a role in weight homeostasis. Involved in the control of feeding behavior through the central melanocortin system. Acts as alpha melanocyte-stimulating hormone antagonist by inhibiting cAMP production mediated by stimulation of melanocortin receptors within the hypothalamus and adrenal gland. Has very low activity with MC5R (By similarity). Is an inverse agonist for MC3R and MC4R being able to suppress their constitutive activity. It promotes MC3R and MC4R endocytosis in an arrestin-dependent manner	corticotropin releasing hormone; This hormone from hypothalamus regulates the release of corticotropin from pituitary gland	0.720
AGRP	GCG	ENSP00000290953	ENSP00000387662	agouti related protein homolog (mouse); Plays a role in weight homeostasis. Involved in the control of feeding behavior through the central melanocortin system. Acts as alpha melanocyte-stimulating hormone antagonist by inhibiting cAMP production mediated by stimulation of melanocortin receptors within the hypothalamus and adrenal gland. Has very low activity with MC5R (By similarity). Is an inverse agonist for MC3R and MC4R being able to suppress their constitutive activity. It promotes MC3R and MC4R endocytosis in an arrestin-dependent manner	glucagon; Glicentin may modulate gastric acid secretion and the gastro-pyloro-duodenal activity. May play an important role in intestinal mucosal growth in the early period of life	0.570
AGRP	GHRH	ENSP00000290953	ENSP00000237527	agouti related protein homolog (mouse); Plays a role in weight homeostasis. Involved in the control of feeding behavior through the central melanocortin system. Acts as alpha melanocyte-stimulating hormone antagonist by inhibiting cAMP production mediated by stimulation of melanocortin receptors within the hypothalamus and adrenal gland. Has very low activity with MC5R (By similarity). Is an inverse agonist for MC3R and MC4R being able to suppress their constitutive activity. It promotes MC3R and MC4R endocytosis in an arrestin-dependent manner	growth hormone releasing hormone; GRF is released by the hypothalamus and acts on the adenohypophyse to stimulate the secretion of growth hormone	0.563
AGRP	MC3R	ENSP00000290953	ENSP00000243911	agouti related protein homolog (mouse); Plays a role in weight homeostasis. Involved in the control of feeding behavior through the central melanocortin system. Acts as alpha melanocyte-stimulating hormone antagonist by inhibiting cAMP production mediated by stimulation of melanocortin receptors within the hypothalamus and adrenal gland. Has very low activity with MC5R (By similarity). Is an inverse agonist for MC3R and MC4R being able to suppress their constitutive activity. It promotes MC3R and MC4R endocytosis in an arrestin-dependent manner	melanocortin 3 receptor; Receptor for MSH (alpha, beta and gamma) and ACTH. This receptor is mediated by G proteins which activate adenylate cyclase	0.988
AGRP	NPS	ENSP00000290953	ENSP00000381105	agouti related protein homolog (mouse); Plays a role in weight homeostasis. Involved in the control of feeding behavior through the central melanocortin system. Acts as alpha melanocyte-stimulating hormone antagonist by inhibiting cAMP production mediated by stimulation of melanocortin receptors within the hypothalamus and adrenal gland. Has very low activity with MC5R (By similarity). Is an inverse agonist for MC3R and MC4R being able to suppress their constitutive activity. It promotes MC3R and MC4R endocytosis in an arrestin-dependent manner	neuropeptide S; Modulates arousal and anxiety. May play an important anorexigenic role. Binds to its receptor NPSR1 with nanomolar affinity to increase intracellular calcium concentrations (By similarity)	0.818
AGRP	POMC	ENSP00000290953	ENSP00000264708	agouti related protein homolog (mouse); Plays a role in weight homeostasis. Involved in the control of feeding behavior through the central melanocortin system. Acts as alpha melanocyte-stimulating hormone antagonist by inhibiting cAMP production mediated by stimulation of melanocortin receptors within the hypothalamus and adrenal gland. Has very low activity with MC5R (By similarity). Is an inverse agonist for MC3R and MC4R being able to suppress their constitutive activity. It promotes MC3R and MC4R endocytosis in an arrestin-dependent manner	proopiomelanocortin; ACTH stimulates the adrenal glands to release cortisol	0.987
AVP	AGRP	ENSP00000369647	ENSP00000290953	arginine vasopressin; Neurophysin 2 specifically binds vasopressin	agouti related protein homolog (mouse); Plays a role in weight homeostasis. Involved in the control of feeding behavior through the central melanocortin system. Acts as alpha melanocyte-stimulating hormone antagonist by inhibiting cAMP production mediated by stimulation of melanocortin receptors within the hypothalamus and adrenal gland. Has very low activity with MC5R (By similarity). Is an inverse agonist for MC3R and MC4R being able to suppress their constitutive activity. It promotes MC3R and MC4R endocytosis in an arrestin-dependent manner	0.414
AVP	CRH	ENSP00000369647	ENSP00000276571	arginine vasopressin; Neurophysin 2 specifically binds vasopressin	corticotropin releasing hormone; This hormone from hypothalamus regulates the release of corticotropin from pituitary gland	0.997
AVP	CRHR2	ENSP00000369647	ENSP00000340943	arginine vasopressin; Neurophysin 2 specifically binds vasopressin	corticotropin releasing hormone receptor 2; This is a receptor for corticotropin releasing factor. Shows high-affinity CRF binding. Also binds to urocortin I, II and III. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase	0.944
AVP	GCG	ENSP00000369647	ENSP00000387662	arginine vasopressin; Neurophysin 2 specifically binds vasopressin	glucagon; Glicentin may modulate gastric acid secretion and the gastro-pyloro-duodenal activity. May play an important role in intestinal mucosal growth in the early period of life	0.963
AVP	GHRH	ENSP00000369647	ENSP00000237527	arginine vasopressin; Neurophysin 2 specifically binds vasopressin	growth hormone releasing hormone; GRF is released by the hypothalamus and acts on the adenohypophyse to stimulate the secretion of growth hormone	0.954
AVP	GLP1R	ENSP00000369647	ENSP00000362353	arginine vasopressin; Neurophysin 2 specifically binds vasopressin	glucagon-like peptide 1 receptor; This is a receptor for glucagon-like peptide 1. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase	0.910
AVP	GNAS	ENSP00000369647	ENSP00000360141	arginine vasopressin; Neurophysin 2 specifically binds vasopressin	GNAS complex locus; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(s) protein is involved in hormonal regulation of adenylate cyclase- it activates the cyclase in response to beta-adrenergic stimuli. XLas isoforms interact with the same set of receptors as Gnas isoforms (By similarity)	0.913
AVP	MC3R	ENSP00000369647	ENSP00000243911	arginine vasopressin; Neurophysin 2 specifically binds vasopressin	melanocortin 3 receptor; Receptor for MSH (alpha, beta and gamma) and ACTH. This receptor is mediated by G proteins which activate adenylate cyclase	0.920
AVP	NPS	ENSP00000369647	ENSP00000381105	arginine vasopressin; Neurophysin 2 specifically binds vasopressin	neuropeptide S; Modulates arousal and anxiety. May play an important anorexigenic role. Binds to its receptor NPSR1 with nanomolar affinity to increase intracellular calcium concentrations (By similarity)	0.980
AVP	POMC	ENSP00000369647	ENSP00000264708	arginine vasopressin; Neurophysin 2 specifically binds vasopressin	proopiomelanocortin; ACTH stimulates the adrenal glands to release cortisol	0.987
CRH	AGRP	ENSP00000276571	ENSP00000290953	corticotropin releasing hormone; This hormone from hypothalamus regulates the release of corticotropin from pituitary gland	agouti related protein homolog (mouse); Plays a role in weight homeostasis. Involved in the control of feeding behavior through the central melanocortin system. Acts as alpha melanocyte-stimulating hormone antagonist by inhibiting cAMP production mediated by stimulation of melanocortin receptors within the hypothalamus and adrenal gland. Has very low activity with MC5R (By similarity). Is an inverse agonist for MC3R and MC4R being able to suppress their constitutive activity. It promotes MC3R and MC4R endocytosis in an arrestin-dependent manner	0.720
CRH	AVP	ENSP00000276571	ENSP00000369647	corticotropin releasing hormone; This hormone from hypothalamus regulates the release of corticotropin from pituitary gland	arginine vasopressin; Neurophysin 2 specifically binds vasopressin	0.997
CRH	CRHR2	ENSP00000276571	ENSP00000340943	corticotropin releasing hormone; This hormone from hypothalamus regulates the release of corticotropin from pituitary gland	corticotropin releasing hormone receptor 2; This is a receptor for corticotropin releasing factor. Shows high-affinity CRF binding. Also binds to urocortin I, II and III. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase	0.995

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