node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
APOC1 | PEPD | ENSP00000252491 | ENSP00000244137 | apolipoprotein C-I; Appears to modulate the interaction of APOE with beta- migrating VLDL and inhibit binding of beta-VLDL to the LDL receptor-related protein. Binds free fatty acids and reduces their intracellular esterification | peptidase D | 0.755 |
CNDP2 | GSR | ENSP00000325548 | ENSP00000221130 | CNDP dipeptidase 2 (metallopeptidase M20 family); Hydrolyzes a variety of dipeptides including L-carnosine but has a strong preference for Cys-Gly. Isoform 2 may be play a role as tumor suppressor in hepatocellular carcinoma (HCC) cells | glutathione reductase; Maintains high levels of reduced glutathione in the cytosol | 0.500 |
CNDP2 | PEPD | ENSP00000325548 | ENSP00000244137 | CNDP dipeptidase 2 (metallopeptidase M20 family); Hydrolyzes a variety of dipeptides including L-carnosine but has a strong preference for Cys-Gly. Isoform 2 may be play a role as tumor suppressor in hepatocellular carcinoma (HCC) cells | peptidase D | 0.726 |
CNDP2 | UBC | ENSP00000325548 | ENSP00000344818 | CNDP dipeptidase 2 (metallopeptidase M20 family); Hydrolyzes a variety of dipeptides including L-carnosine but has a strong preference for Cys-Gly. Isoform 2 may be play a role as tumor suppressor in hepatocellular carcinoma (HCC) cells | ubiquitin C | 0.873 |
EIF5A | PEPD | ENSP00000336702 | ENSP00000244137 | eukaryotic translation initiation factor 5A; mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. With syntenin SDCBP, functions as a regulator of p53/TP53 and p53/TP53-dependent apoptosis. Regulates also TNF- alpha-mediated apoptosis. Mediates effects of polyamines on neuronal process extension and survival. May play an importa [...] | peptidase D | 0.741 |
EIF5A | UBB | ENSP00000336702 | ENSP00000304697 | eukaryotic translation initiation factor 5A; mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. With syntenin SDCBP, functions as a regulator of p53/TP53 and p53/TP53-dependent apoptosis. Regulates also TNF- alpha-mediated apoptosis. Mediates effects of polyamines on neuronal process extension and survival. May play an importa [...] | ubiquitin B | 0.587 |
EIF5A | UBC | ENSP00000336702 | ENSP00000344818 | eukaryotic translation initiation factor 5A; mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. With syntenin SDCBP, functions as a regulator of p53/TP53 and p53/TP53-dependent apoptosis. Regulates also TNF- alpha-mediated apoptosis. Mediates effects of polyamines on neuronal process extension and survival. May play an importa [...] | ubiquitin C | 0.986 |
ERBB2 | PEPD | ENSP00000269571 | ENSP00000244137 | v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian); Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition o [...] | peptidase D | 0.825 |
ERBB2 | PTGS2 | ENSP00000269571 | ENSP00000356438 | v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian); Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition o [...] | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase); Mediates the formation of prostaglandins from arachidonate. May have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity | 0.947 |
ERBB2 | UBB | ENSP00000269571 | ENSP00000304697 | v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian); Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition o [...] | ubiquitin B | 0.959 |
ERBB2 | UBC | ENSP00000269571 | ENSP00000344818 | v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian); Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition o [...] | ubiquitin C | 0.999 |
GSR | CNDP2 | ENSP00000221130 | ENSP00000325548 | glutathione reductase; Maintains high levels of reduced glutathione in the cytosol | CNDP dipeptidase 2 (metallopeptidase M20 family); Hydrolyzes a variety of dipeptides including L-carnosine but has a strong preference for Cys-Gly. Isoform 2 may be play a role as tumor suppressor in hepatocellular carcinoma (HCC) cells | 0.500 |
GSR | NOS3 | ENSP00000221130 | ENSP00000297494 | glutathione reductase; Maintains high levels of reduced glutathione in the cytosol | nitric oxide synthase 3 (endothelial cell); Produces nitric oxide (NO) (By similarity) | 0.553 |
GSR | PEPD | ENSP00000221130 | ENSP00000244137 | glutathione reductase; Maintains high levels of reduced glutathione in the cytosol | peptidase D | 0.816 |
GSR | UBC | ENSP00000221130 | ENSP00000344818 | glutathione reductase; Maintains high levels of reduced glutathione in the cytosol | ubiquitin C | 0.744 |
NOS3 | GSR | ENSP00000297494 | ENSP00000221130 | nitric oxide synthase 3 (endothelial cell); Produces nitric oxide (NO) (By similarity) | glutathione reductase; Maintains high levels of reduced glutathione in the cytosol | 0.553 |
NOS3 | PEPD | ENSP00000297494 | ENSP00000244137 | nitric oxide synthase 3 (endothelial cell); Produces nitric oxide (NO) (By similarity) | peptidase D | 0.814 |
NOS3 | PTGS2 | ENSP00000297494 | ENSP00000356438 | nitric oxide synthase 3 (endothelial cell); Produces nitric oxide (NO) (By similarity) | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase); Mediates the formation of prostaglandins from arachidonate. May have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity | 0.480 |
NOS3 | UBC | ENSP00000297494 | ENSP00000344818 | nitric oxide synthase 3 (endothelial cell); Produces nitric oxide (NO) (By similarity) | ubiquitin C | 0.617 |
PEPD | APOC1 | ENSP00000244137 | ENSP00000252491 | peptidase D | apolipoprotein C-I; Appears to modulate the interaction of APOE with beta- migrating VLDL and inhibit binding of beta-VLDL to the LDL receptor-related protein. Binds free fatty acids and reduces their intracellular esterification | 0.755 |