node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EPO | IL2RG | ENSP00000252723 | ENSP00000363318 | erythropoietin; Erythropoietin is the principal hormone involved in the regulation of erythrocyte differentiation and the maintenance of a physiological level of circulating erythrocyte mass | interleukin 2 receptor, gamma; Common subunit for the receptors for a variety of interleukins | 0.803 |
EPO | IL9R | ENSP00000252723 | ENSP00000244174 | erythropoietin; Erythropoietin is the principal hormone involved in the regulation of erythrocyte differentiation and the maintenance of a physiological level of circulating erythrocyte mass | interleukin 9 receptor; This is a receptor for interleukin-9 | 0.834 |
EPO | JAK1 | ENSP00000252723 | ENSP00000343204 | erythropoietin; Erythropoietin is the principal hormone involved in the regulation of erythrocyte differentiation and the maintenance of a physiological level of circulating erythrocyte mass | Janus kinase 1; Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor | 0.977 |
EPO | JAK3 | ENSP00000252723 | ENSP00000391676 | erythropoietin; Erythropoietin is the principal hormone involved in the regulation of erythrocyte differentiation and the maintenance of a physiological level of circulating erythrocyte mass | Janus kinase 3; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, or differentiation. Mediates essential signaling events in both innate and adaptive immunity and plays a crucial role in hematopoiesis during T-cells development. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors sharing the common subunit gamma such as IL2R, IL4R, IL7R, IL9R, IL15R and IL21R. Following ligand binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor [...] | 0.891 |
EPO | SOCS1 | ENSP00000252723 | ENSP00000329418 | erythropoietin; Erythropoietin is the principal hormone involved in the regulation of erythrocyte differentiation and the maintenance of a physiological level of circulating erythrocyte mass | suppressor of cytokine signaling 1; SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein- tyrosine activity. Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival (By similarity). Probable substrate recognition component of a [...] | 0.865 |
IFNG | IL2RG | ENSP00000229135 | ENSP00000363318 | interferon, gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity) | interleukin 2 receptor, gamma; Common subunit for the receptors for a variety of interleukins | 0.866 |
IFNG | IL4 | ENSP00000229135 | ENSP00000231449 | interferon, gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity) | interleukin 4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes | 0.762 |
IFNG | IL9R | ENSP00000229135 | ENSP00000244174 | interferon, gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity) | interleukin 9 receptor; This is a receptor for interleukin-9 | 0.828 |
IFNG | JAK1 | ENSP00000229135 | ENSP00000343204 | interferon, gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity) | Janus kinase 1; Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor | 0.940 |
IFNG | SOCS1 | ENSP00000229135 | ENSP00000329418 | interferon, gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity) | suppressor of cytokine signaling 1; SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein- tyrosine activity. Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival (By similarity). Probable substrate recognition component of a [...] | 0.936 |
IL13 | IL2RG | ENSP00000304915 | ENSP00000363318 | interleukin 13; Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses | interleukin 2 receptor, gamma; Common subunit for the receptors for a variety of interleukins | 0.883 |
IL13 | IL4 | ENSP00000304915 | ENSP00000231449 | interleukin 13; Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses | interleukin 4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes | 0.997 |
IL13 | IL9 | ENSP00000304915 | ENSP00000274520 | interleukin 13; Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses | interleukin 9; Supports IL-2 independent and IL-4 independent growth of helper T-cells | 0.941 |
IL13 | IL9R | ENSP00000304915 | ENSP00000244174 | interleukin 13; Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses | interleukin 9 receptor; This is a receptor for interleukin-9 | 0.866 |
IL13 | JAK1 | ENSP00000304915 | ENSP00000343204 | interleukin 13; Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses | Janus kinase 1; Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor | 0.499 |
IL13 | JAK3 | ENSP00000304915 | ENSP00000391676 | interleukin 13; Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses | Janus kinase 3; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, or differentiation. Mediates essential signaling events in both innate and adaptive immunity and plays a crucial role in hematopoiesis during T-cells development. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors sharing the common subunit gamma such as IL2R, IL4R, IL7R, IL9R, IL15R and IL21R. Following ligand binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor [...] | 0.480 |
IL13 | SOCS1 | ENSP00000304915 | ENSP00000329418 | interleukin 13; Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses | suppressor of cytokine signaling 1; SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein- tyrosine activity. Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival (By similarity). Probable substrate recognition component of a [...] | 0.866 |
IL22 | IL2RG | ENSP00000329384 | ENSP00000363318 | interleukin 22; Cytokine that contributes to the inflammatory response in vivo | interleukin 2 receptor, gamma; Common subunit for the receptors for a variety of interleukins | 0.806 |
IL22 | IL4 | ENSP00000329384 | ENSP00000231449 | interleukin 22; Cytokine that contributes to the inflammatory response in vivo | interleukin 4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes | 0.416 |
IL22 | IL9 | ENSP00000329384 | ENSP00000274520 | interleukin 22; Cytokine that contributes to the inflammatory response in vivo | interleukin 9; Supports IL-2 independent and IL-4 independent growth of helper T-cells | 0.414 |