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PCOTH PCOTH ANKRD53 ANKRD53 OTX1 OTX1 PAIP2B PAIP2B SLC1A1 SLC1A1 PABPC1 PABPC1 ATP1B3 ATP1B3 UBC UBC ADCY6 ADCY6 PAIP1 PAIP1 MITF MITF
"PAIP2B" - poly(A) binding protein interacting protein 2B in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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second shell of interactors
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Predicted Interactions
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protein homology
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PAIP2Bpoly(A) binding protein interacting protein 2B (123 aa)    
Predicted Functional Partners:
PABPC1
poly(A) binding protein, cytoplasmic 1; Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism such as pre- mRNA splicing. Its function in translational initiation regulation can either be enhanced by PAIP1 or repressed by PAIP2. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo. Involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability [...] (636 aa)
        score_image   score_image   0.943
ATP1B3
ATPase, Na+/K+ transporting, beta 3 polypeptide; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-3 subunit is not known (279 aa)
            score_image   0.800
ADCY6
adenylate cyclase 6; Membrane-bound, calcium-inhibitable adenylyl cyclase (By similarity) (1168 aa)
            score_image   0.753
SLC1A1
solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1; Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium. Negatively regulated by ARL6IP5 (By similarity) (524 aa)
            score_image   0.751
UBC
ubiquitin C (685 aa)
        score_image       0.564
PAIP1
poly(A) binding protein interacting protein 1; Acts as a coactivator in the regulation of translation initiation of poly(A)-containing mRNAs. Its stimulatory activity on translation is mediated via its action on PABPC1. Competes with PAIP2 for binding to PABPC1. Its association with EIF4A and PABPC1 may potentiate contacts between mRNA termini. May also be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of insta [...] (479 aa)
            score_image   0.564
ANKRD53
ankyrin repeat domain 53 (530 aa)
            score_image   0.479
PCOTH
protein PCOTH isoform 1 ; May be involved in growth and survival of prostate cancer cells through the TAF-Ibeta pathway (100 aa)
            score_image   0.471
MITF
microphthalmia-associated transcription factor (520 aa)
            score_image   0.439
OTX1
orthodenticle homeobox 1; Probably plays a role in the development of the brain and the sense organs. Can bind to the BCD target sequence (BTS)- 5’-TCTAATCCC-3’ (354 aa)
            score_image   0.410
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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