node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CAPNS1 | SNRNP27 | ENSP00000246533 | ENSP00000244227 | calpain, small subunit 1; Regulatory subunit of the calcium-regulated non- lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction | small nuclear ribonucleoprotein 27kDa (U4/U6.U5); May play a role in mRNA splicing | 0.476 |
CAPNS1 | SNRNP40 | ENSP00000246533 | ENSP00000263694 | calpain, small subunit 1; Regulatory subunit of the calcium-regulated non- lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction | small nuclear ribonucleoprotein 40kDa (U5); Component of the U5 small nuclear ribonucleoprotein (snRNP) complex. The U5 snRNP is part of the spliceosome, a multiprotein complex that catalyzes the removal of introns from pre-messenger RNAs | 0.720 |
CHERP | SNRNP27 | ENSP00000439856 | ENSP00000244227 | calcium homeostasis endoplasmic reticulum protein; Involved in calcium homeostasis, growth and proliferation | small nuclear ribonucleoprotein 27kDa (U4/U6.U5); May play a role in mRNA splicing | 0.728 |
CHERP | SNRNP70 | ENSP00000439856 | ENSP00000472998 | calcium homeostasis endoplasmic reticulum protein; Involved in calcium homeostasis, growth and proliferation | small nuclear ribonucleoprotein 70kDa (U1) | 0.702 |
CHERP | SRPK2 | ENSP00000439856 | ENSP00000377262 | calcium homeostasis endoplasmic reticulum protein; Involved in calcium homeostasis, growth and proliferation | SRSF protein kinase 2; Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Promotes neuronal apoptosis by up-regulating cyclin-D1 (CCND1) expression. This is done by the phosphorylation of SRSF2, leading to the suppression of p53/TP53 phosphorylation thereby relieving the repressive effect of p53/TP53 on cyclin-D1 (CCND1) expression. Phosphorylates ACIN1, and [...] | 0.461 |
FKBP1B | SNRNP27 | ENSP00000370373 | ENSP00000244227 | FK506 binding protein 1B, 12.6 kDa; Has the potential to contribute to the immunosuppressive and toxic effects of FK506 and rapamycin. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides | small nuclear ribonucleoprotein 27kDa (U4/U6.U5); May play a role in mRNA splicing | 0.457 |
IARS | SNRNP27 | ENSP00000364794 | ENSP00000244227 | isoleucyl-tRNA synthetase | small nuclear ribonucleoprotein 27kDa (U4/U6.U5); May play a role in mRNA splicing | 0.473 |
PRPF4 | SNRNP27 | ENSP00000363313 | ENSP00000244227 | PRP4 pre-mRNA processing factor 4 homolog (yeast); Participates in pre-mRNA splicing. Part of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome | small nuclear ribonucleoprotein 27kDa (U4/U6.U5); May play a role in mRNA splicing | 0.896 |
PRPF4 | SNRNP40 | ENSP00000363313 | ENSP00000263694 | PRP4 pre-mRNA processing factor 4 homolog (yeast); Participates in pre-mRNA splicing. Part of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome | small nuclear ribonucleoprotein 40kDa (U5); Component of the U5 small nuclear ribonucleoprotein (snRNP) complex. The U5 snRNP is part of the spliceosome, a multiprotein complex that catalyzes the removal of introns from pre-messenger RNAs | 0.990 |
PRPF4 | SNRNP70 | ENSP00000363313 | ENSP00000472998 | PRP4 pre-mRNA processing factor 4 homolog (yeast); Participates in pre-mRNA splicing. Part of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome | small nuclear ribonucleoprotein 70kDa (U1) | 0.945 |
PRPF4 | USP39 | ENSP00000363313 | ENSP00000312981 | PRP4 pre-mRNA processing factor 4 homolog (yeast); Participates in pre-mRNA splicing. Part of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome | ubiquitin specific peptidase 39 | 0.897 |
SNRNP27 | CAPNS1 | ENSP00000244227 | ENSP00000246533 | small nuclear ribonucleoprotein 27kDa (U4/U6.U5); May play a role in mRNA splicing | calpain, small subunit 1; Regulatory subunit of the calcium-regulated non- lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction | 0.476 |
SNRNP27 | CHERP | ENSP00000244227 | ENSP00000439856 | small nuclear ribonucleoprotein 27kDa (U4/U6.U5); May play a role in mRNA splicing | calcium homeostasis endoplasmic reticulum protein; Involved in calcium homeostasis, growth and proliferation | 0.728 |
SNRNP27 | FKBP1B | ENSP00000244227 | ENSP00000370373 | small nuclear ribonucleoprotein 27kDa (U4/U6.U5); May play a role in mRNA splicing | FK506 binding protein 1B, 12.6 kDa; Has the potential to contribute to the immunosuppressive and toxic effects of FK506 and rapamycin. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides | 0.457 |
SNRNP27 | IARS | ENSP00000244227 | ENSP00000364794 | small nuclear ribonucleoprotein 27kDa (U4/U6.U5); May play a role in mRNA splicing | isoleucyl-tRNA synthetase | 0.473 |
SNRNP27 | PRPF4 | ENSP00000244227 | ENSP00000363313 | small nuclear ribonucleoprotein 27kDa (U4/U6.U5); May play a role in mRNA splicing | PRP4 pre-mRNA processing factor 4 homolog (yeast); Participates in pre-mRNA splicing. Part of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome | 0.896 |
SNRNP27 | SNRNP40 | ENSP00000244227 | ENSP00000263694 | small nuclear ribonucleoprotein 27kDa (U4/U6.U5); May play a role in mRNA splicing | small nuclear ribonucleoprotein 40kDa (U5); Component of the U5 small nuclear ribonucleoprotein (snRNP) complex. The U5 snRNP is part of the spliceosome, a multiprotein complex that catalyzes the removal of introns from pre-messenger RNAs | 0.472 |
SNRNP27 | SNRNP70 | ENSP00000244227 | ENSP00000472998 | small nuclear ribonucleoprotein 27kDa (U4/U6.U5); May play a role in mRNA splicing | small nuclear ribonucleoprotein 70kDa (U1) | 0.685 |
SNRNP27 | SRA1 | ENSP00000244227 | ENSP00000337513 | small nuclear ribonucleoprotein 27kDa (U4/U6.U5); May play a role in mRNA splicing | steroid receptor RNA activator 1; Functional RNA which acts as a transcriptional coactivator that selectively enhances steroid receptor-mediated transactivation ligand-independently through a mechanism involving the modulating N-terminal domain (AF-1) of steroid receptors. Also mediates transcriptional coactivation of steroid receptors ligand- dependently through the steroid-binding domain (AF-2). Enhances cellular proliferation and differentiation and promotes apoptosis in vivo. May play a role in tumorigenesis | 0.733 |
SNRNP27 | SRPK2 | ENSP00000244227 | ENSP00000377262 | small nuclear ribonucleoprotein 27kDa (U4/U6.U5); May play a role in mRNA splicing | SRSF protein kinase 2; Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Promotes neuronal apoptosis by up-regulating cyclin-D1 (CCND1) expression. This is done by the phosphorylation of SRSF2, leading to the suppression of p53/TP53 phosphorylation thereby relieving the repressive effect of p53/TP53 on cyclin-D1 (CCND1) expression. Phosphorylates ACIN1, and [...] | 0.932 |