DST protein (Homo sapiens) - STRING network view

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protein of unknown 3D structure

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Known Interactions

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Score

DST

dystonin (5171 aa)

Predicted Functional Partners:

COL17A1

0.996

KIF2C

0.902

SPAG5

0.900

C15orf23

0.900

ITGB4

0.881

ERBB2IP

0.850

KRT14

0.787

FKBP10

0.742

KIF18B

0.720

MAPRE1

0.719

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C15orf23	DST	ENSP00000249776	ENSP00000244364	chromosome 15 open reading frame 23; Essential component of the mitotic spindle required for faithful chromosome segregation and progression into anaphase. Promotes the metaphase-to-anaphase transition and is required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture. The astrin (SPAG5)-kinastrin (SKAP) complex promotes stable microtubule-kinetochore attachments	dystonin	0.900
C15orf23	KIF18B	ENSP00000249776	ENSP00000341466	chromosome 15 open reading frame 23; Essential component of the mitotic spindle required for faithful chromosome segregation and progression into anaphase. Promotes the metaphase-to-anaphase transition and is required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture. The astrin (SPAG5)-kinastrin (SKAP) complex promotes stable microtubule-kinetochore attachments	kinesin family member 18B; In complex with KIF2C, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. Its major role may be to transport KIF2C and/or MAPRE1 along microtubules	0.775
C15orf23	KIF2C	ENSP00000249776	ENSP00000361298	chromosome 15 open reading frame 23; Essential component of the mitotic spindle required for faithful chromosome segregation and progression into anaphase. Promotes the metaphase-to-anaphase transition and is required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture. The astrin (SPAG5)-kinastrin (SKAP) complex promotes stable microtubule-kinetochore attachments	kinesin family member 2C; In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis	0.922
C15orf23	SPAG5	ENSP00000249776	ENSP00000323300	chromosome 15 open reading frame 23; Essential component of the mitotic spindle required for faithful chromosome segregation and progression into anaphase. Promotes the metaphase-to-anaphase transition and is required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture. The astrin (SPAG5)-kinastrin (SKAP) complex promotes stable microtubule-kinetochore attachments	sperm associated antigen 5; Essential component of the mitotic spindle required for normal chromosome segregation and progression into anaphase. Required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture. The astrin (SPAG5)-kinastrin (SKAP) complex promotes stable microtubule-kinetochore attachments	0.987
COL17A1	DST	ENSP00000340937	ENSP00000244364	collagen, type XVII, alpha 1; May play a role in the integrity of hemidesmosome and the attachment of basal keratinocytes to the underlying basement membrane	dystonin	0.996
COL17A1	ITGB4	ENSP00000340937	ENSP00000200181	collagen, type XVII, alpha 1; May play a role in the integrity of hemidesmosome and the attachment of basal keratinocytes to the underlying basement membrane	integrin, beta 4; Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility	0.997
COL17A1	KRT14	ENSP00000340937	ENSP00000167586	collagen, type XVII, alpha 1; May play a role in the integrity of hemidesmosome and the attachment of basal keratinocytes to the underlying basement membrane	keratin 14; The nonhelical tail domain is involved in promoting KRT5-KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro	0.506
DST	C15orf23	ENSP00000244364	ENSP00000249776	dystonin	chromosome 15 open reading frame 23; Essential component of the mitotic spindle required for faithful chromosome segregation and progression into anaphase. Promotes the metaphase-to-anaphase transition and is required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture. The astrin (SPAG5)-kinastrin (SKAP) complex promotes stable microtubule-kinetochore attachments	0.900
DST	COL17A1	ENSP00000244364	ENSP00000340937	dystonin	collagen, type XVII, alpha 1; May play a role in the integrity of hemidesmosome and the attachment of basal keratinocytes to the underlying basement membrane	0.996
DST	ERBB2IP	ENSP00000244364	ENSP00000370330	dystonin	erbb2 interacting protein	0.850
DST	FKBP10	ENSP00000244364	ENSP00000317232	dystonin	FK506 binding protein 10, 65 kDa; PPIases accelerate the folding of proteins during protein synthesis	0.742
DST	ITGB4	ENSP00000244364	ENSP00000200181	dystonin	integrin, beta 4; Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility	0.881
DST	KIF18B	ENSP00000244364	ENSP00000341466	dystonin	kinesin family member 18B; In complex with KIF2C, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. Its major role may be to transport KIF2C and/or MAPRE1 along microtubules	0.720
DST	KIF2C	ENSP00000244364	ENSP00000361298	dystonin	kinesin family member 2C; In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis	0.902
DST	KRT14	ENSP00000244364	ENSP00000167586	dystonin	keratin 14; The nonhelical tail domain is involved in promoting KRT5-KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro	0.787
DST	MAPRE1	ENSP00000244364	ENSP00000364721	dystonin	microtubule-associated protein, RP/EB family, member 1; Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes cytoplasmic microtubule nucleation and elongation. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration	0.719
DST	SPAG5	ENSP00000244364	ENSP00000323300	dystonin	sperm associated antigen 5; Essential component of the mitotic spindle required for normal chromosome segregation and progression into anaphase. Required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture. The astrin (SPAG5)-kinastrin (SKAP) complex promotes stable microtubule-kinetochore attachments	0.900
ERBB2IP	DST	ENSP00000370330	ENSP00000244364	erbb2 interacting protein	dystonin	0.850
ERBB2IP	ITGB4	ENSP00000370330	ENSP00000200181	erbb2 interacting protein	integrin, beta 4; Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility	0.607
FKBP10	DST	ENSP00000317232	ENSP00000244364	FK506 binding protein 10, 65 kDa; PPIases accelerate the folding of proteins during protein synthesis	dystonin	0.742

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