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LARS2 LARS2 LARS LARS RARS2 RARS2 MARS MARS EPRS EPRS EARS2 EARS2 ENSG00000269547 ENSG00000269547 AARS2 AARS2 YARS2 YARS2 MARS2 MARS2 FARS2 FARS2
"AARS2" - alanyl-tRNA synthetase 2, mitochondrial in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
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colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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[Homology]
Score
AARS2alanyl-tRNA synthetase 2, mitochondrial; Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction- alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain (By similarity) (985 aa)    
Predicted Functional Partners:
EPRS
glutamyl-prolyl-tRNA synthetase (1512 aa)
score_image     score_image     score_image   0.898
FARS2
phenylalanyl-tRNA synthetase 2, mitochondrial; Catalyzes direct attachment of p-Tyr (Tyr) to tRNAPhe. Permits also, with a lower efficiency, the attachment of m-Tyr to tRNAPhe, thereby opening the way for delivery of the misacylated tRNA to the ribosome and incorporation of ROS-damaged amino acid into proteins (451 aa)
      score_image     score_image   0.884
LARS2
leucyl-tRNA synthetase 2, mitochondrial (903 aa)
score_image     score_image     score_image   0.879
ENSG00000269547
F-box only protein 17 (588 aa)
      score_image     score_image   0.879
MARS
methionyl-tRNA synthetase (900 aa)
      score_image     score_image   0.876
EARS2
glutamyl-tRNA synthetase 2, mitochondrial; Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction- glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) (523 aa)
score_image     score_image     score_image   0.874
LARS
leucyl-tRNA synthetase; Catalyzes the specific attachment of an amino acid to its cognate tRNA in a two step reaction- the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. Exhibits a post-transfer editing activity to hydrolyze mischarged tRNAs (1176 aa)
score_image     score_image     score_image   0.870
MARS2
methionyl-tRNA synthetase 2, mitochondrial (593 aa)
      score_image     score_image   0.838
YARS2
tyrosyl-tRNA synthetase 2, mitochondrial; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction- tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) (477 aa)
score_image     score_image     score_image   0.830
RARS2
arginyl-tRNA synthetase 2, mitochondrial (578 aa)
      score_image     score_image   0.805
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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