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UNC45A UNC45A TET2 TET2 TET3 TET3 MTFP1 MTFP1 APOBEC2 APOBEC2 UNC45B UNC45B TET1 TET1 APOBEC1 APOBEC1 CDA CDA APOBEC4 APOBEC4 APOB APOB
"APOBEC2" - apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2 in Homo sapiens
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APOBEC2apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2; Probable C to U editing enzyme whose physiological substrate is not yet known. Does not display detectable apoB mRNA editing. Has a low intrinsic cytidine deaminase activity. May play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation (224 aa)    
Predicted Functional Partners:
CDA
cytidine deaminase; This enzyme scavenge exogenous and endogenous cytidine and 2’-deoxycytidine for UMP synthesis (146 aa)
             score_image   0.690
APOBEC1
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1; Catalytic component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in the APOB mRNA. Also involved in CGA (Arg) to UGA (Stop) editing in the NF1 mRNA. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation (236 aa)
         score_image   score_image score_image 0.676
UNC45B
unc-45 homolog B (C. elegans); Acts as a co-chaperone for HSP90 and is required for proper folding of the myosin motor domain. Plays a role in sarcomere formation during muscle cell development (By similarity) (931 aa)
       score_image     score_image   0.627
UNC45A
unc-45 homolog A (C. elegans); Acts as co-chaperone for HSP90. Prevents the stimulation of HSP90AB1 ATPase activity by AHSA1. Positive factor in promoting PGR function in the cell. May be necessary for proper folding of myosin (Potential). Necessary for normal cell proliferation. Necessary for normal myotube formation and myosin accumulation during muscle cell development. May play a role in erythropoiesis in stroma cells in the spleen (By similarity) (944 aa)
       score_image     score_image   0.625
TET1
tet methylcytosine dioxygenase 1; Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5- hydroxymethylcytosine (5hmC) and plays a key role in active DNA demethylation. Also mediates subsequent conversion of 5hmC into 5- formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation. Methylation at the C5 position of cytosine bases is an epigenetic modification of the mammalian genome which plays an important role in transcript [...] (2136 aa)
             score_image   0.592
TET2
tet methylcytosine dioxygenase 2; Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5- hydroxymethylcytosine (5hmC) and plays a key role in active DNA demethylation. Also mediates subsequent conversion of 5hmC into 5- formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation. Methylation at the C5 position of cytosine bases is an epigenetic modification of the mammalian genome which plays an important role in transcript [...] (2002 aa)
             score_image   0.588
APOBEC4
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative); Putative C to U editing enzyme whose physiological substrate is not yet known (By similarity) (367 aa)
             score_image   0.580
MTFP1
mitochondrial fission process 1; Involved in the mitochondrial division probably by regulating membrane fission. Loss-of-function induces the release of cytochrome c, which activates the caspase cascade and leads to apoptosis (166 aa)
             score_image   0.520
APOB
apolipoprotein B (including Ag(x) antigen) (4563 aa)
             score_image   0.408
TET3
tet methylcytosine dioxygenase 3; Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5- hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming in the zygote following fertilization. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation. In zygotes, DNA demethylation occurs selectively in the paternal pronucleus before the first cell d [...] (1660 aa)
             score_image   0.406
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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