| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| DPY30 | MEA1 | ENSP00000295066 | ENSP00000244711 | dpy-30 homolog (C. elegans); As part of the MLL1/MLL complex, involved in the methylation of histone H3 at ’Lys-4’, particularly trimethylation. Histone H3 ’Lys-4’ methylation represents a specific tag for epigenetic transcriptional activation. May play some role in histone H3 acetylation. In a teratocarcinoma cell, plays a crucial role in retinoic acid-induced differentiation along the neural lineage, regulating gene induction and H3 ’Lys-4’ methylation at key developmental loci. May also play an indirect or direct role in endosomal transport | male-enhanced antigen 1; May play an important role in spermatogenesis and/or testis development | 0.938 |
| DPY30 | NUP153 | ENSP00000295066 | ENSP00000262077 | dpy-30 homolog (C. elegans); As part of the MLL1/MLL complex, involved in the methylation of histone H3 at ’Lys-4’, particularly trimethylation. Histone H3 ’Lys-4’ methylation represents a specific tag for epigenetic transcriptional activation. May play some role in histone H3 acetylation. In a teratocarcinoma cell, plays a crucial role in retinoic acid-induced differentiation along the neural lineage, regulating gene induction and H3 ’Lys-4’ methylation at key developmental loci. May also play an indirect or direct role in endosomal transport | nucleoporin 153kDa; Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear membrane at NPC. The repeat- cont [...] | 0.911 |
| GOLGA3 | MEA1 | ENSP00000204726 | ENSP00000244711 | golgin A3; Golgi auto-antigen; probably involved in maintaining Golgi structure | male-enhanced antigen 1; May play an important role in spermatogenesis and/or testis development | 0.752 |
| GOLGA3 | SPATA16 | ENSP00000204726 | ENSP00000341765 | golgin A3; Golgi auto-antigen; probably involved in maintaining Golgi structure | spermatogenesis associated 16 | 0.801 |
| KLHDC3 | MEA1 | ENSP00000313995 | ENSP00000244711 | kelch domain containing 3; May be involved in meiotic recombination process | male-enhanced antigen 1; May play an important role in spermatogenesis and/or testis development | 0.866 |
| KLHDC3 | PPP2R5D | ENSP00000313995 | ENSP00000417963 | kelch domain containing 3; May be involved in meiotic recombination process | protein phosphatase 2, regulatory subunit B’, delta; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment | 0.886 |
| KLHL1 | MEA1 | ENSP00000367075 | ENSP00000244711 | kelch-like 1 (Drosophila); May play a role in organizing the actin cytoskeleton of the brain cells | male-enhanced antigen 1; May play an important role in spermatogenesis and/or testis development | 0.748 |
| KLHL1 | PPP2R5D | ENSP00000367075 | ENSP00000417963 | kelch-like 1 (Drosophila); May play a role in organizing the actin cytoskeleton of the brain cells | protein phosphatase 2, regulatory subunit B’, delta; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment | 0.489 |
| MEA1 | DPY30 | ENSP00000244711 | ENSP00000295066 | male-enhanced antigen 1; May play an important role in spermatogenesis and/or testis development | dpy-30 homolog (C. elegans); As part of the MLL1/MLL complex, involved in the methylation of histone H3 at ’Lys-4’, particularly trimethylation. Histone H3 ’Lys-4’ methylation represents a specific tag for epigenetic transcriptional activation. May play some role in histone H3 acetylation. In a teratocarcinoma cell, plays a crucial role in retinoic acid-induced differentiation along the neural lineage, regulating gene induction and H3 ’Lys-4’ methylation at key developmental loci. May also play an indirect or direct role in endosomal transport | 0.938 |
| MEA1 | GOLGA3 | ENSP00000244711 | ENSP00000204726 | male-enhanced antigen 1; May play an important role in spermatogenesis and/or testis development | golgin A3; Golgi auto-antigen; probably involved in maintaining Golgi structure | 0.752 |
| MEA1 | KLHDC3 | ENSP00000244711 | ENSP00000313995 | male-enhanced antigen 1; May play an important role in spermatogenesis and/or testis development | kelch domain containing 3; May be involved in meiotic recombination process | 0.866 |
| MEA1 | KLHL1 | ENSP00000244711 | ENSP00000367075 | male-enhanced antigen 1; May play an important role in spermatogenesis and/or testis development | kelch-like 1 (Drosophila); May play a role in organizing the actin cytoskeleton of the brain cells | 0.748 |
| MEA1 | NCAPD2 | ENSP00000244711 | ENSP00000325017 | male-enhanced antigen 1; May play an important role in spermatogenesis and/or testis development | non-SMC condensin I complex, subunit D2; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. May target the condensin complex to DNA via its C-terminal domain | 0.974 |
| MEA1 | NUP153 | ENSP00000244711 | ENSP00000262077 | male-enhanced antigen 1; May play an important role in spermatogenesis and/or testis development | nucleoporin 153kDa; Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear membrane at NPC. The repeat- cont [...] | 0.970 |
| MEA1 | PPP2R5D | ENSP00000244711 | ENSP00000417963 | male-enhanced antigen 1; May play an important role in spermatogenesis and/or testis development | protein phosphatase 2, regulatory subunit B’, delta; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment | 0.863 |
| MEA1 | RAD21 | ENSP00000244711 | ENSP00000297338 | male-enhanced antigen 1; May play an important role in spermatogenesis and/or testis development | RAD21 homolog (S. pombe); Cleavable component of the cohesin complex, involved in chromosome cohesion during cell cycle, in DNA repair, and in apoptosis. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At metaphase-anaphase transition, this protein is cleaved by separase/ESPL1 and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Als [...] | 0.704 |
| MEA1 | SPATA16 | ENSP00000244711 | ENSP00000341765 | male-enhanced antigen 1; May play an important role in spermatogenesis and/or testis development | spermatogenesis associated 16 | 0.760 |
| MEA1 | ZFY | ENSP00000244711 | ENSP00000155093 | male-enhanced antigen 1; May play an important role in spermatogenesis and/or testis development | zinc finger protein, Y-linked; Probable transcriptional activator. Binds to the consensus sequence 5’-AGGCCY-3’ | 0.740 |
| NCAPD2 | MEA1 | ENSP00000325017 | ENSP00000244711 | non-SMC condensin I complex, subunit D2; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. May target the condensin complex to DNA via its C-terminal domain | male-enhanced antigen 1; May play an important role in spermatogenesis and/or testis development | 0.974 |
| NCAPD2 | NUP153 | ENSP00000325017 | ENSP00000262077 | non-SMC condensin I complex, subunit D2; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. May target the condensin complex to DNA via its C-terminal domain | nucleoporin 153kDa; Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear membrane at NPC. The repeat- cont [...] | 0.972 |
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