node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CDH2 | MEF2A | ENSP00000269141 | ENSP00000346389 | cadherin 2, type 1, N-cadherin (neuronal); Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density (By similarity) | myocyte enhancer factor 2A | 0.929 |
CDH2 | MEF2C | ENSP00000269141 | ENSP00000340874 | cadherin 2, type 1, N-cadherin (neuronal); Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density (By similarity) | myocyte enhancer factor 2C; Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle- specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platel [...] | 0.927 |
CDH2 | SOX4 | ENSP00000269141 | ENSP00000244745 | cadherin 2, type 1, N-cadherin (neuronal); Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density (By similarity) | SRY (sex determining region Y)-box 4; Transcriptional activator that binds with high affinity to the T-cell enhancer motif 5’-AACAAAG-3’ motif | 0.832 |
CDH2 | TP53 | ENSP00000269141 | ENSP00000269305 | cadherin 2, type 1, N-cadherin (neuronal); Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density (By similarity) | tumor protein p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity) | 0.548 |
DICER1 | SOX4 | ENSP00000343745 | ENSP00000244745 | dicer 1, ribonuclease type III; Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, EIF2C2/AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre- miRNAs) to mature miRNAs and then load them onto EIF2C2/AGO2. EIF2C2/AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. Also cleaves double-stranded RNA to produce short interfering [...] | SRY (sex determining region Y)-box 4; Transcriptional activator that binds with high affinity to the T-cell enhancer motif 5’-AACAAAG-3’ motif | 0.842 |
DICER1 | TP53 | ENSP00000343745 | ENSP00000269305 | dicer 1, ribonuclease type III; Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, EIF2C2/AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre- miRNAs) to mature miRNAs and then load them onto EIF2C2/AGO2. EIF2C2/AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. Also cleaves double-stranded RNA to produce short interfering [...] | tumor protein p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity) | 0.912 |
KLF5 | MEF2A | ENSP00000366915 | ENSP00000346389 | Kruppel-like factor 5 (intestinal); Transcription factor that binds to GC box promoter elements. Activates the transcription of these genes | myocyte enhancer factor 2A | 0.872 |
KLF5 | SOX4 | ENSP00000366915 | ENSP00000244745 | Kruppel-like factor 5 (intestinal); Transcription factor that binds to GC box promoter elements. Activates the transcription of these genes | SRY (sex determining region Y)-box 4; Transcriptional activator that binds with high affinity to the T-cell enhancer motif 5’-AACAAAG-3’ motif | 0.836 |
KLF5 | TP53 | ENSP00000366915 | ENSP00000269305 | Kruppel-like factor 5 (intestinal); Transcription factor that binds to GC box promoter elements. Activates the transcription of these genes | tumor protein p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity) | 0.866 |
MECOM | SOX4 | ENSP00000264674 | ENSP00000244745 | MDS1 and EVI1 complex locus | SRY (sex determining region Y)-box 4; Transcriptional activator that binds with high affinity to the T-cell enhancer motif 5’-AACAAAG-3’ motif | 0.817 |
MECOM | SPI1 | ENSP00000264674 | ENSP00000227163 | MDS1 and EVI1 complex locus | spleen focus forming virus (SFFV) proviral integration oncogene spi1; Binds to the PU-box, a purine-rich DNA sequence (5’- GAGGAA-3’) that can act as a lymphoid-specific enhancer. This protein is a transcriptional activator that may be specifically involved in the differentiation or activation of macrophages or B- cells. Also binds RNA and may modulate pre-mRNA splicing (By similarity) | 0.860 |
MEF2A | CDH2 | ENSP00000346389 | ENSP00000269141 | myocyte enhancer factor 2A | cadherin 2, type 1, N-cadherin (neuronal); Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density (By similarity) | 0.929 |
MEF2A | KLF5 | ENSP00000346389 | ENSP00000366915 | myocyte enhancer factor 2A | Kruppel-like factor 5 (intestinal); Transcription factor that binds to GC box promoter elements. Activates the transcription of these genes | 0.872 |
MEF2A | MEF2C | ENSP00000346389 | ENSP00000340874 | myocyte enhancer factor 2A | myocyte enhancer factor 2C; Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle- specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platel [...] | 0.904 |
MEF2A | SOX4 | ENSP00000346389 | ENSP00000244745 | myocyte enhancer factor 2A | SRY (sex determining region Y)-box 4; Transcriptional activator that binds with high affinity to the T-cell enhancer motif 5’-AACAAAG-3’ motif | 0.846 |
MEF2A | UBE2I | ENSP00000346389 | ENSP00000324897 | myocyte enhancer factor 2A | ubiquitin-conjugating enzyme E2I; Accepts the ubiquitin-like proteins SUMO1, SUMO2, SUMO3 and SUMO4 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2 or CBX4. Can catalyze the formation of poly- SUMO chains. Necessary for sumoylation of FOXL2 and KAT5. Essential for nuclear architecture and chromosome segregation. Sumoylates p53/TP53 at ’Lys-386’ (By similarity) | 0.664 |
MEF2C | CDH2 | ENSP00000340874 | ENSP00000269141 | myocyte enhancer factor 2C; Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle- specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platel [...] | cadherin 2, type 1, N-cadherin (neuronal); Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density (By similarity) | 0.927 |
MEF2C | MEF2A | ENSP00000340874 | ENSP00000346389 | myocyte enhancer factor 2C; Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle- specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platel [...] | myocyte enhancer factor 2A | 0.904 |
MEF2C | SOX4 | ENSP00000340874 | ENSP00000244745 | myocyte enhancer factor 2C; Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle- specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platel [...] | SRY (sex determining region Y)-box 4; Transcriptional activator that binds with high affinity to the T-cell enhancer motif 5’-AACAAAG-3’ motif | 0.850 |
MEF2C | UBE2I | ENSP00000340874 | ENSP00000324897 | myocyte enhancer factor 2C; Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle- specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platel [...] | ubiquitin-conjugating enzyme E2I; Accepts the ubiquitin-like proteins SUMO1, SUMO2, SUMO3 and SUMO4 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2 or CBX4. Can catalyze the formation of poly- SUMO chains. Necessary for sumoylation of FOXL2 and KAT5. Essential for nuclear architecture and chromosome segregation. Sumoylates p53/TP53 at ’Lys-386’ (By similarity) | 0.916 |