| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ANKRD45 | NRN1 | ENSP00000331268 | ENSP00000244766 | ankyrin repeat domain 45 | neuritin 1; Promotes neurite outgrowth and especially branching of neuritic processes in primary hippocampal and cortical cells (By similarity) | 0.643 |
| CNTNAP1 | NRN1 | ENSP00000264638 | ENSP00000244766 | contactin associated protein 1; Seems to play a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Seems to demarcate the paranodal region of the axo-glial junction. In association with contactin may have a role in the signaling between axons and myelinating glial cells | neuritin 1; Promotes neurite outgrowth and especially branching of neuritic processes in primary hippocampal and cortical cells (By similarity) | 0.469 |
| ELAVL1 | NRN1 | ENSP00000385269 | ENSP00000244766 | ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R); Involved in 3’-UTR ARE-mediated MYC stabilization. Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, HUR binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA and AUUUUUA motifs. Binds preferentially to the 5’-UUUU[AG]UUU-3’ motif in vitro | neuritin 1; Promotes neurite outgrowth and especially branching of neuritic processes in primary hippocampal and cortical cells (By similarity) | 0.596 |
| ELAVL2 | ELAVL3 | ENSP00000369460 | ENSP00000352162 | ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B); Binds RNA. Seems to recognize a GAAA motif. Can bind to its own 3’-UTR, the FOS 3’-UTR and the ID 3’-UTR | ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C); Binds to AU-rich sequences (AREs) of target mRNAs, including VEGF mRNA. May also bind poly-A tracts via RRM 3 (By similarity). May be involved in neuronal differentiation and maintenance | 0.622 |
| ELAVL2 | ELAVL4 | ENSP00000369460 | ENSP00000349594 | ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B); Binds RNA. Seems to recognize a GAAA motif. Can bind to its own 3’-UTR, the FOS 3’-UTR and the ID 3’-UTR | ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4; May play a role in neuron-specific RNA processing. Protects CDKN1A mRNA from decay by binding to its 3’-UTR (By similarity). Binds to AU-rich sequences (AREs) of target mRNAs, including VEGF and FOS mRNA | 0.593 |
| ELAVL2 | NRN1 | ENSP00000369460 | ENSP00000244766 | ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B); Binds RNA. Seems to recognize a GAAA motif. Can bind to its own 3’-UTR, the FOS 3’-UTR and the ID 3’-UTR | neuritin 1; Promotes neurite outgrowth and especially branching of neuritic processes in primary hippocampal and cortical cells (By similarity) | 0.717 |
| ELAVL3 | ELAVL2 | ENSP00000352162 | ENSP00000369460 | ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C); Binds to AU-rich sequences (AREs) of target mRNAs, including VEGF mRNA. May also bind poly-A tracts via RRM 3 (By similarity). May be involved in neuronal differentiation and maintenance | ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B); Binds RNA. Seems to recognize a GAAA motif. Can bind to its own 3’-UTR, the FOS 3’-UTR and the ID 3’-UTR | 0.622 |
| ELAVL3 | NRN1 | ENSP00000352162 | ENSP00000244766 | ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C); Binds to AU-rich sequences (AREs) of target mRNAs, including VEGF mRNA. May also bind poly-A tracts via RRM 3 (By similarity). May be involved in neuronal differentiation and maintenance | neuritin 1; Promotes neurite outgrowth and especially branching of neuritic processes in primary hippocampal and cortical cells (By similarity) | 0.617 |
| ELAVL4 | ELAVL2 | ENSP00000349594 | ENSP00000369460 | ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4; May play a role in neuron-specific RNA processing. Protects CDKN1A mRNA from decay by binding to its 3’-UTR (By similarity). Binds to AU-rich sequences (AREs) of target mRNAs, including VEGF and FOS mRNA | ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B); Binds RNA. Seems to recognize a GAAA motif. Can bind to its own 3’-UTR, the FOS 3’-UTR and the ID 3’-UTR | 0.593 |
| ELAVL4 | NRN1 | ENSP00000349594 | ENSP00000244766 | ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4; May play a role in neuron-specific RNA processing. Protects CDKN1A mRNA from decay by binding to its 3’-UTR (By similarity). Binds to AU-rich sequences (AREs) of target mRNAs, including VEGF and FOS mRNA | neuritin 1; Promotes neurite outgrowth and especially branching of neuritic processes in primary hippocampal and cortical cells (By similarity) | 0.804 |
| FBXO3 | NRN1 | ENSP00000265651 | ENSP00000244766 | F-box protein 3; Substrate recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex. Mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. In the presence of PML, HIPK2 ubiquitination still occurs, but degradation is prevented. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53- dependent transactivation | neuritin 1; Promotes neurite outgrowth and especially branching of neuritic processes in primary hippocampal and cortical cells (By similarity) | 0.418 |
| HNF1B | NRN1 | ENSP00000225893 | ENSP00000244766 | HNF1 homeobox B; Transcription factor, probably binds to the inverted palindrome 5’-GTTAATNATTAAC-3’ | neuritin 1; Promotes neurite outgrowth and especially branching of neuritic processes in primary hippocampal and cortical cells (By similarity) | 0.489 |
| NRN1 | ANKRD45 | ENSP00000244766 | ENSP00000331268 | neuritin 1; Promotes neurite outgrowth and especially branching of neuritic processes in primary hippocampal and cortical cells (By similarity) | ankyrin repeat domain 45 | 0.643 |
| NRN1 | CNTNAP1 | ENSP00000244766 | ENSP00000264638 | neuritin 1; Promotes neurite outgrowth and especially branching of neuritic processes in primary hippocampal and cortical cells (By similarity) | contactin associated protein 1; Seems to play a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Seems to demarcate the paranodal region of the axo-glial junction. In association with contactin may have a role in the signaling between axons and myelinating glial cells | 0.469 |
| NRN1 | ELAVL1 | ENSP00000244766 | ENSP00000385269 | neuritin 1; Promotes neurite outgrowth and especially branching of neuritic processes in primary hippocampal and cortical cells (By similarity) | ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R); Involved in 3’-UTR ARE-mediated MYC stabilization. Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, HUR binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA and AUUUUUA motifs. Binds preferentially to the 5’-UUUU[AG]UUU-3’ motif in vitro | 0.596 |
| NRN1 | ELAVL2 | ENSP00000244766 | ENSP00000369460 | neuritin 1; Promotes neurite outgrowth and especially branching of neuritic processes in primary hippocampal and cortical cells (By similarity) | ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B); Binds RNA. Seems to recognize a GAAA motif. Can bind to its own 3’-UTR, the FOS 3’-UTR and the ID 3’-UTR | 0.717 |
| NRN1 | ELAVL3 | ENSP00000244766 | ENSP00000352162 | neuritin 1; Promotes neurite outgrowth and especially branching of neuritic processes in primary hippocampal and cortical cells (By similarity) | ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C); Binds to AU-rich sequences (AREs) of target mRNAs, including VEGF mRNA. May also bind poly-A tracts via RRM 3 (By similarity). May be involved in neuronal differentiation and maintenance | 0.617 |
| NRN1 | ELAVL4 | ENSP00000244766 | ENSP00000349594 | neuritin 1; Promotes neurite outgrowth and especially branching of neuritic processes in primary hippocampal and cortical cells (By similarity) | ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4; May play a role in neuron-specific RNA processing. Protects CDKN1A mRNA from decay by binding to its 3’-UTR (By similarity). Binds to AU-rich sequences (AREs) of target mRNAs, including VEGF and FOS mRNA | 0.804 |
| NRN1 | FBXO3 | ENSP00000244766 | ENSP00000265651 | neuritin 1; Promotes neurite outgrowth and especially branching of neuritic processes in primary hippocampal and cortical cells (By similarity) | F-box protein 3; Substrate recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex. Mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. In the presence of PML, HIPK2 ubiquitination still occurs, but degradation is prevented. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53- dependent transactivation | 0.418 |
| NRN1 | HNF1B | ENSP00000244766 | ENSP00000225893 | neuritin 1; Promotes neurite outgrowth and especially branching of neuritic processes in primary hippocampal and cortical cells (By similarity) | HNF1 homeobox B; Transcription factor, probably binds to the inverted palindrome 5’-GTTAATNATTAAC-3’ | 0.489 |
Share
