SLC10A2 protein (Homo sapiens) - STRING network view

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SLC10A2

solute carrier family 10 (sodium/bile acid cotransporter family), member 2; Plays a critical role in the sodium-dependent reabsorption of bile acids from the lumen of the small intestine. Plays a key role in cholesterol metabolism (348 aa)

Predicted Functional Partners:

FABP6

0.981

ABCC3

0.957

ATP6V0C

0.948

ALB

0.933

HNF1A

0.886

GBA2

0.806

CYP7A1

0.767

ABCB11

0.739

NR1H4

0.665

SLCO1A2

0.665

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABCB11	ALB	ENSP00000263817	ENSP00000295897	ATP-binding cassette, sub-family B (MDR/TAP), member 11; Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes	albumin	0.412
ABCB11	CYP7A1	ENSP00000263817	ENSP00000301645	ATP-binding cassette, sub-family B (MDR/TAP), member 11; Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes	cytochrome P450, family 7, subfamily A, polypeptide 1; Catalyzes a rate-limiting step in cholesterol catabolism and bile acid biosynthesis by introducing a hydrophilic moiety at position 7 of cholesterol. Important for cholesterol homeostasis	0.824
ABCB11	FABP6	ENSP00000263817	ENSP00000377549	ATP-binding cassette, sub-family B (MDR/TAP), member 11; Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes	fatty acid binding protein 6, ileal; Ileal protein which stimulates gastric acid and pepsinogen secretion. Seems to be able to bind to bile salts and bilirubins. Isoform 2 is essential for the survival of colon cancer cells to bile acid-induced apoptosis	0.757
ABCB11	GBA2	ENSP00000263817	ENSP00000367343	ATP-binding cassette, sub-family B (MDR/TAP), member 11; Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes	glucosidase, beta (bile acid) 2; Non-lysosomal glucosylceramidase that catalyzes the conversion of glucosylceramide (GlcCer) to free glucose and ceramide. Involved in sphingomyelin generation and prevention of glycolipid accumulation. May also catalyze the hydrolysis of bile acid 3-O-glucosides, however, the relevance of such activity is unclear in vivo	0.590
ABCB11	NR1H4	ENSP00000263817	ENSP00000447149	ATP-binding cassette, sub-family B (MDR/TAP), member 11; Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes	nuclear receptor subfamily 1, group H, member 4; Ligand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression, via two distinct mechanisms. Activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 to this locus	0.962
ABCB11	SLC10A2	ENSP00000263817	ENSP00000245312	ATP-binding cassette, sub-family B (MDR/TAP), member 11; Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes	solute carrier family 10 (sodium/bile acid cotransporter family), member 2; Plays a critical role in the sodium-dependent reabsorption of bile acids from the lumen of the small intestine. Plays a key role in cholesterol metabolism	0.739
ABCB11	SLCO1A2	ENSP00000263817	ENSP00000305974	ATP-binding cassette, sub-family B (MDR/TAP), member 11; Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes	solute carrier organic anion transporter family, member 1A2; Mediates the Na(+)-independent transport of organic anions such as sulfobromophthalein (BSP) and conjugated (taurocholate) and unconjugated (cholate) bile acids (By similarity). Selectively inhibited by the grapefruit juice component naringin	0.813
ABCC3	ALB	ENSP00000285238	ENSP00000295897	ATP-binding cassette, sub-family C (CFTR/MRP), member 3	albumin	0.925
ABCC3	CYP7A1	ENSP00000285238	ENSP00000301645	ATP-binding cassette, sub-family C (CFTR/MRP), member 3	cytochrome P450, family 7, subfamily A, polypeptide 1; Catalyzes a rate-limiting step in cholesterol catabolism and bile acid biosynthesis by introducing a hydrophilic moiety at position 7 of cholesterol. Important for cholesterol homeostasis	0.549
ABCC3	FABP6	ENSP00000285238	ENSP00000377549	ATP-binding cassette, sub-family C (CFTR/MRP), member 3	fatty acid binding protein 6, ileal; Ileal protein which stimulates gastric acid and pepsinogen secretion. Seems to be able to bind to bile salts and bilirubins. Isoform 2 is essential for the survival of colon cancer cells to bile acid-induced apoptosis	0.933
ABCC3	NR1H4	ENSP00000285238	ENSP00000447149	ATP-binding cassette, sub-family C (CFTR/MRP), member 3	nuclear receptor subfamily 1, group H, member 4; Ligand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression, via two distinct mechanisms. Activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 to this locus	0.533
ABCC3	SLC10A2	ENSP00000285238	ENSP00000245312	ATP-binding cassette, sub-family C (CFTR/MRP), member 3	solute carrier family 10 (sodium/bile acid cotransporter family), member 2; Plays a critical role in the sodium-dependent reabsorption of bile acids from the lumen of the small intestine. Plays a key role in cholesterol metabolism	0.957
ABCC3	SLCO1A2	ENSP00000285238	ENSP00000305974	ATP-binding cassette, sub-family C (CFTR/MRP), member 3	solute carrier organic anion transporter family, member 1A2; Mediates the Na(+)-independent transport of organic anions such as sulfobromophthalein (BSP) and conjugated (taurocholate) and unconjugated (cholate) bile acids (By similarity). Selectively inhibited by the grapefruit juice component naringin	0.973
ALB	ABCB11	ENSP00000295897	ENSP00000263817	albumin	ATP-binding cassette, sub-family B (MDR/TAP), member 11; Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes	0.412
ALB	ABCC3	ENSP00000295897	ENSP00000285238	albumin	ATP-binding cassette, sub-family C (CFTR/MRP), member 3	0.925
ALB	CYP7A1	ENSP00000295897	ENSP00000301645	albumin	cytochrome P450, family 7, subfamily A, polypeptide 1; Catalyzes a rate-limiting step in cholesterol catabolism and bile acid biosynthesis by introducing a hydrophilic moiety at position 7 of cholesterol. Important for cholesterol homeostasis	0.422
ALB	FABP6	ENSP00000295897	ENSP00000377549	albumin	fatty acid binding protein 6, ileal; Ileal protein which stimulates gastric acid and pepsinogen secretion. Seems to be able to bind to bile salts and bilirubins. Isoform 2 is essential for the survival of colon cancer cells to bile acid-induced apoptosis	0.928
ALB	HNF1A	ENSP00000295897	ENSP00000257555	albumin	HNF1 homeobox A; Transcriptional activator that regulates the tissue specific expression of multiple genes, especially in pancreatic islet cells and in liver. Required for the expression of several liver specific genes. Binds to the inverted palindrome 5’- GTTAATNATTAAC-3’	0.961
ALB	SLC10A2	ENSP00000295897	ENSP00000245312	albumin	solute carrier family 10 (sodium/bile acid cotransporter family), member 2; Plays a critical role in the sodium-dependent reabsorption of bile acids from the lumen of the small intestine. Plays a key role in cholesterol metabolism	0.933
ALB	SLCO1A2	ENSP00000295897	ENSP00000305974	albumin	solute carrier organic anion transporter family, member 1A2; Mediates the Na(+)-independent transport of organic anions such as sulfobromophthalein (BSP) and conjugated (taurocholate) and unconjugated (cholate) bile acids (By similarity). Selectively inhibited by the grapefruit juice component naringin	0.944

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