| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CD40 | CD70 | ENSP00000361359 | ENSP00000245903 | CD40 molecule, TNF receptor superfamily member 5; Receptor for TNFSF5/CD40LG | CD70 molecule; Cytokine that binds to CD27. Plays a role in T-cell activation. Induces the proliferation of costimulated T-cells and enhances the generation of cytolytic T-cells | 0.563 |
| CD40 | MAP3K5 | ENSP00000361359 | ENSP00000351908 | CD40 molecule, TNF receptor superfamily member 5; Receptor for TNFSF5/CD40LG | mitogen-activated protein kinase kinase kinase 5; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signaling for determination of cell fate such as differentiation and survival. Plays a crucial role in the apoptosis signal transduction pathway through mitochondria-dependent caspase activation. MAP3K5/ASK1 is required for the innate immune response, which is essential for host defense against a wide range of pathogens. Me [...] | 0.518 |
| CD40 | TNFRSF9 | ENSP00000361359 | ENSP00000366729 | CD40 molecule, TNF receptor superfamily member 5; Receptor for TNFSF5/CD40LG | tumor necrosis factor receptor superfamily, member 9; Receptor for TNFSF9/4-1BBL. Possibly active during T cell activation | 0.509 |
| CD40 | TNFSF4 | ENSP00000361359 | ENSP00000281834 | CD40 molecule, TNF receptor superfamily member 5; Receptor for TNFSF5/CD40LG | tumor necrosis factor (ligand) superfamily, member 4; Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production | 0.517 |
| CD40 | TNFSF8 | ENSP00000361359 | ENSP00000223795 | CD40 molecule, TNF receptor superfamily member 5; Receptor for TNFSF5/CD40LG | tumor necrosis factor (ligand) superfamily, member 8; Cytokine that binds to TNFRSF8/CD30. Induces proliferation of T-cells | 0.472 |
| CD40 | TNFSF9 | ENSP00000361359 | ENSP00000245817 | CD40 molecule, TNF receptor superfamily member 5; Receptor for TNFSF5/CD40LG | tumor necrosis factor (ligand) superfamily, member 9; Cytokine that binds to TNFRSF9. Induces the proliferation of activated peripheral blood T-cells. May have a role in activation-induced cell death (AICD). May play a role in cognate interactions between T-cells and B-cells/macrophages | 0.886 |
| CD40 | TRAF1 | ENSP00000361359 | ENSP00000362994 | CD40 molecule, TNF receptor superfamily member 5; Receptor for TNFSF5/CD40LG | TNF receptor-associated factor 1; Adapter molecule that regulates the activation of NF- kappa-B and JNK. Plays a role in the regulation of cell survival and apoptosis. The heterotrimer formed by TRAF1 and TRAF2 is part of a E3 ubiquitin-protein ligase complex that promotes ubiquitination of target proteins, such as MAP3K14. The TRAF1/TRAF2 complex recruits the antiapoptotic E3 protein- ubiquitin ligases BIRC2 and BIRC3 to TNFRSF1B/TNFR2 | 0.998 |
| CD40 | TRAF2 | ENSP00000361359 | ENSP00000247668 | CD40 molecule, TNF receptor superfamily member 5; Receptor for TNFSF5/CD40LG | TNF receptor-associated factor 2; Regulates activation of NF-kappa-B and JNK and plays a central role in the regulation of cell survival and apoptosis. Required for normal antibody isotype switching from IgM to IgG. Has E3 ubiquitin-protein ligase activity and promotes ’Lys-63’- linked ubiquitination of target proteins, such as BIRC3, RIPK1 and TICAM1. Is an essential constituent of several E3 ubiquitin- protein ligase complexes, where it promotes the ubiquitination of target proteins by bringing them into contact with other E3 ubiquitin ligases. Regulates BIRC2 and BIRC3 protein level [...] | 0.999 |
| CD70 | CD40 | ENSP00000245903 | ENSP00000361359 | CD70 molecule; Cytokine that binds to CD27. Plays a role in T-cell activation. Induces the proliferation of costimulated T-cells and enhances the generation of cytolytic T-cells | CD40 molecule, TNF receptor superfamily member 5; Receptor for TNFSF5/CD40LG | 0.563 |
| CD70 | TNFRSF4 | ENSP00000245903 | ENSP00000368538 | CD70 molecule; Cytokine that binds to CD27. Plays a role in T-cell activation. Induces the proliferation of costimulated T-cells and enhances the generation of cytolytic T-cells | tumor necrosis factor receptor superfamily, member 4; Receptor for TNFSF4/OX40L/GP34 | 0.581 |
| CD70 | TNFRSF9 | ENSP00000245903 | ENSP00000366729 | CD70 molecule; Cytokine that binds to CD27. Plays a role in T-cell activation. Induces the proliferation of costimulated T-cells and enhances the generation of cytolytic T-cells | tumor necrosis factor receptor superfamily, member 9; Receptor for TNFSF9/4-1BBL. Possibly active during T cell activation | 0.516 |
| CD70 | TNFSF4 | ENSP00000245903 | ENSP00000281834 | CD70 molecule; Cytokine that binds to CD27. Plays a role in T-cell activation. Induces the proliferation of costimulated T-cells and enhances the generation of cytolytic T-cells | tumor necrosis factor (ligand) superfamily, member 4; Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production | 0.623 |
| CD70 | TNFSF8 | ENSP00000245903 | ENSP00000223795 | CD70 molecule; Cytokine that binds to CD27. Plays a role in T-cell activation. Induces the proliferation of costimulated T-cells and enhances the generation of cytolytic T-cells | tumor necrosis factor (ligand) superfamily, member 8; Cytokine that binds to TNFRSF8/CD30. Induces proliferation of T-cells | 0.707 |
| CD70 | TNFSF9 | ENSP00000245903 | ENSP00000245817 | CD70 molecule; Cytokine that binds to CD27. Plays a role in T-cell activation. Induces the proliferation of costimulated T-cells and enhances the generation of cytolytic T-cells | tumor necrosis factor (ligand) superfamily, member 9; Cytokine that binds to TNFRSF9. Induces the proliferation of activated peripheral blood T-cells. May have a role in activation-induced cell death (AICD). May play a role in cognate interactions between T-cells and B-cells/macrophages | 0.725 |
| IRAK2 | TNFSF9 | ENSP00000256458 | ENSP00000245817 | interleukin-1 receptor-associated kinase 2; Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization | tumor necrosis factor (ligand) superfamily, member 9; Cytokine that binds to TNFRSF9. Induces the proliferation of activated peripheral blood T-cells. May have a role in activation-induced cell death (AICD). May play a role in cognate interactions between T-cells and B-cells/macrophages | 0.901 |
| MAP3K5 | CD40 | ENSP00000351908 | ENSP00000361359 | mitogen-activated protein kinase kinase kinase 5; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signaling for determination of cell fate such as differentiation and survival. Plays a crucial role in the apoptosis signal transduction pathway through mitochondria-dependent caspase activation. MAP3K5/ASK1 is required for the innate immune response, which is essential for host defense against a wide range of pathogens. Me [...] | CD40 molecule, TNF receptor superfamily member 5; Receptor for TNFSF5/CD40LG | 0.518 |
| MAP3K5 | TNFRSF9 | ENSP00000351908 | ENSP00000366729 | mitogen-activated protein kinase kinase kinase 5; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signaling for determination of cell fate such as differentiation and survival. Plays a crucial role in the apoptosis signal transduction pathway through mitochondria-dependent caspase activation. MAP3K5/ASK1 is required for the innate immune response, which is essential for host defense against a wide range of pathogens. Me [...] | tumor necrosis factor receptor superfamily, member 9; Receptor for TNFSF9/4-1BBL. Possibly active during T cell activation | 0.900 |
| MAP3K5 | TNFSF9 | ENSP00000351908 | ENSP00000245817 | mitogen-activated protein kinase kinase kinase 5; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signaling for determination of cell fate such as differentiation and survival. Plays a crucial role in the apoptosis signal transduction pathway through mitochondria-dependent caspase activation. MAP3K5/ASK1 is required for the innate immune response, which is essential for host defense against a wide range of pathogens. Me [...] | tumor necrosis factor (ligand) superfamily, member 9; Cytokine that binds to TNFRSF9. Induces the proliferation of activated peripheral blood T-cells. May have a role in activation-induced cell death (AICD). May play a role in cognate interactions between T-cells and B-cells/macrophages | 0.900 |
| MAP3K5 | TRAF1 | ENSP00000351908 | ENSP00000362994 | mitogen-activated protein kinase kinase kinase 5; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signaling for determination of cell fate such as differentiation and survival. Plays a crucial role in the apoptosis signal transduction pathway through mitochondria-dependent caspase activation. MAP3K5/ASK1 is required for the innate immune response, which is essential for host defense against a wide range of pathogens. Me [...] | TNF receptor-associated factor 1; Adapter molecule that regulates the activation of NF- kappa-B and JNK. Plays a role in the regulation of cell survival and apoptosis. The heterotrimer formed by TRAF1 and TRAF2 is part of a E3 ubiquitin-protein ligase complex that promotes ubiquitination of target proteins, such as MAP3K14. The TRAF1/TRAF2 complex recruits the antiapoptotic E3 protein- ubiquitin ligases BIRC2 and BIRC3 to TNFRSF1B/TNFR2 | 0.993 |
| MAP3K5 | TRAF2 | ENSP00000351908 | ENSP00000247668 | mitogen-activated protein kinase kinase kinase 5; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signaling for determination of cell fate such as differentiation and survival. Plays a crucial role in the apoptosis signal transduction pathway through mitochondria-dependent caspase activation. MAP3K5/ASK1 is required for the innate immune response, which is essential for host defense against a wide range of pathogens. Me [...] | TNF receptor-associated factor 2; Regulates activation of NF-kappa-B and JNK and plays a central role in the regulation of cell survival and apoptosis. Required for normal antibody isotype switching from IgM to IgG. Has E3 ubiquitin-protein ligase activity and promotes ’Lys-63’- linked ubiquitination of target proteins, such as BIRC3, RIPK1 and TICAM1. Is an essential constituent of several E3 ubiquitin- protein ligase complexes, where it promotes the ubiquitination of target proteins by bringing them into contact with other E3 ubiquitin ligases. Regulates BIRC2 and BIRC3 protein level [...] | 0.999 |
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