node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C3 | CD46 | ENSP00000245907 | ENSP00000313875 | complement component 3; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates | CD46 molecule, complement regulatory protein | 0.998 |
C3 | CFD | ENSP00000245907 | ENSP00000332139 | complement component 3; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates | complement factor D (adipsin); Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway | 0.995 |
C3 | CFH | ENSP00000245907 | ENSP00000356399 | complement component 3; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates | complement factor H | 0.999 |
C3 | CFHR1 | ENSP00000245907 | ENSP00000314299 | complement component 3; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates | complement factor H-related 1; Might be involved in complement regulation. Can associate with lipoproteins and may play a role in lipid metabolism | 0.992 |
C3 | CFI | ENSP00000245907 | ENSP00000378130 | complement component 3; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates | complement factor I; Responsible for cleaving the alpha-chains of C4b and C3b in the presence of the cofactors C4-binding protein and factor H respectively | 0.997 |
C3 | CFP | ENSP00000245907 | ENSP00000247153 | complement component 3; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates | complement factor properdin; A positive regulator of the alternate pathway of complement. It binds to and stabilizes the C3- and C5-convertase enzyme complexes | 0.992 |
C3 | CR1 | ENSP00000245907 | ENSP00000356016 | complement component 3; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates | complement component (3b/4b) receptor 1 (Knops blood group); Mediates cellular binding of particles and immune complexes that have activated complement | 0.998 |
C3 | CR2 | ENSP00000245907 | ENSP00000356024 | complement component 3; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates | complement component (3d/Epstein Barr virus) receptor 2; Receptor for complement C3Dd, for the Epstein-Barr virus on human B-cells and T-cells and for HNRPU. Participates in B lymphocytes activation | 0.997 |
C3 | ITGAM | ENSP00000245907 | ENSP00000441691 | complement component 3; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates | integrin, alpha M (complement component 3 receptor 3 subunit); Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain | 0.997 |
C3 | VSIG4 | ENSP00000245907 | ENSP00000363869 | complement component 3; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates | V-set and immunoglobulin domain containing 4; Phagocytic receptor, strong negative regulator of T-cell proliferation and IL2 production. Potent inhibitor of the alternative complement pathway convertases | 0.998 |
CD46 | C3 | ENSP00000313875 | ENSP00000245907 | CD46 molecule, complement regulatory protein | complement component 3; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates | 0.998 |
CD46 | CFI | ENSP00000313875 | ENSP00000378130 | CD46 molecule, complement regulatory protein | complement factor I; Responsible for cleaving the alpha-chains of C4b and C3b in the presence of the cofactors C4-binding protein and factor H respectively | 0.949 |
CD46 | CR1 | ENSP00000313875 | ENSP00000356016 | CD46 molecule, complement regulatory protein | complement component (3b/4b) receptor 1 (Knops blood group); Mediates cellular binding of particles and immune complexes that have activated complement | 0.915 |
CFD | C3 | ENSP00000332139 | ENSP00000245907 | complement factor D (adipsin); Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway | complement component 3; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates | 0.995 |
CFD | CFP | ENSP00000332139 | ENSP00000247153 | complement factor D (adipsin); Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway | complement factor properdin; A positive regulator of the alternate pathway of complement. It binds to and stabilizes the C3- and C5-convertase enzyme complexes | 0.439 |
CFH | C3 | ENSP00000356399 | ENSP00000245907 | complement factor H | complement component 3; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates | 0.999 |
CFH | CFHR1 | ENSP00000356399 | ENSP00000314299 | complement factor H | complement factor H-related 1; Might be involved in complement regulation. Can associate with lipoproteins and may play a role in lipid metabolism | 0.574 |
CFH | CFI | ENSP00000356399 | ENSP00000378130 | complement factor H | complement factor I; Responsible for cleaving the alpha-chains of C4b and C3b in the presence of the cofactors C4-binding protein and factor H respectively | 0.984 |
CFH | ITGAM | ENSP00000356399 | ENSP00000441691 | complement factor H | integrin, alpha M (complement component 3 receptor 3 subunit); Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain | 0.612 |
CFHR1 | C3 | ENSP00000314299 | ENSP00000245907 | complement factor H-related 1; Might be involved in complement regulation. Can associate with lipoproteins and may play a role in lipid metabolism | complement component 3; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates | 0.992 |