RTN2 protein (Homo sapiens) - STRING network view

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Score

RTN2

reticulon 2 (545 aa)

Predicted Functional Partners:

SPAST

0.889

SLC1A1

0.788

AGL

0.733

REEP5

0.728

SEC63

0.696

CARKD

0.664

NUS1

0.661

KIAA0196

0.660

REEP1

0.648

ATL1

0.610

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGL	RTN2	ENSP00000294724	ENSP00000245923	amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase	reticulon 2	0.733
ATL1	KIAA0196	ENSP00000351155	ENSP00000318016	atlastin GTPase 1; GTPase tethering membranes through formation of trans- homooligomer and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. May also regulate Golgi biogenesis. May regulate axonal development	KIAA0196; Component of the WASH complex, a complex present at the surface of endosomes that recruits and activates the Arp2/3 complex to induce actin polymerization. The WASH complex plays a key role in the fission of tubules that serve as transport intermediates during endosome sorting	0.761
ATL1	REEP1	ENSP00000351155	ENSP00000438346	atlastin GTPase 1; GTPase tethering membranes through formation of trans- homooligomer and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. May also regulate Golgi biogenesis. May regulate axonal development	receptor accessory protein 1; Required for endoplasmic reticulum (ER) network formation, shaping and remodeling; it links ER tubules to the cytoskeleton. May also enhance the cell surface expression of odorant receptors	0.948
ATL1	REEP5	ENSP00000351155	ENSP00000368959	atlastin GTPase 1; GTPase tethering membranes through formation of trans- homooligomer and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. May also regulate Golgi biogenesis. May regulate axonal development	receptor accessory protein 5; May promote functional cell surface expression of olfactory receptors	0.533
ATL1	RTN2	ENSP00000351155	ENSP00000245923	atlastin GTPase 1; GTPase tethering membranes through formation of trans- homooligomer and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. May also regulate Golgi biogenesis. May regulate axonal development	reticulon 2	0.610
ATL1	SPAST	ENSP00000351155	ENSP00000320885	atlastin GTPase 1; GTPase tethering membranes through formation of trans- homooligomer and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. May also regulate Golgi biogenesis. May regulate axonal development	spastin; ATP-dependent microtubule severing protein. Microtubule severing may promote reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Required for membrane traffic from the endoplasmic reticulum (ER) to the Golgi and for completion of the abscission stage of cytokinesis. Also plays a role in axon growth and the formation of axonal branches (By similarity)	0.972
CARKD	RTN2	ENSP00000311984	ENSP00000245923	carbohydrate kinase domain containing; Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)	reticulon 2	0.664
KIAA0196	ATL1	ENSP00000318016	ENSP00000351155	KIAA0196; Component of the WASH complex, a complex present at the surface of endosomes that recruits and activates the Arp2/3 complex to induce actin polymerization. The WASH complex plays a key role in the fission of tubules that serve as transport intermediates during endosome sorting	atlastin GTPase 1; GTPase tethering membranes through formation of trans- homooligomer and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. May also regulate Golgi biogenesis. May regulate axonal development	0.761
KIAA0196	REEP1	ENSP00000318016	ENSP00000438346	KIAA0196; Component of the WASH complex, a complex present at the surface of endosomes that recruits and activates the Arp2/3 complex to induce actin polymerization. The WASH complex plays a key role in the fission of tubules that serve as transport intermediates during endosome sorting	receptor accessory protein 1; Required for endoplasmic reticulum (ER) network formation, shaping and remodeling; it links ER tubules to the cytoskeleton. May also enhance the cell surface expression of odorant receptors	0.743
KIAA0196	RTN2	ENSP00000318016	ENSP00000245923	KIAA0196; Component of the WASH complex, a complex present at the surface of endosomes that recruits and activates the Arp2/3 complex to induce actin polymerization. The WASH complex plays a key role in the fission of tubules that serve as transport intermediates during endosome sorting	reticulon 2	0.660
KIAA0196	SPAST	ENSP00000318016	ENSP00000320885	KIAA0196; Component of the WASH complex, a complex present at the surface of endosomes that recruits and activates the Arp2/3 complex to induce actin polymerization. The WASH complex plays a key role in the fission of tubules that serve as transport intermediates during endosome sorting	spastin; ATP-dependent microtubule severing protein. Microtubule severing may promote reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Required for membrane traffic from the endoplasmic reticulum (ER) to the Golgi and for completion of the abscission stage of cytokinesis. Also plays a role in axon growth and the formation of axonal branches (By similarity)	0.744
NUS1	REEP5	ENSP00000357480	ENSP00000368959	nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae); Acts as a specific receptor for the N-terminus of Nogo- B, a neural and cardiovascular regulator. Regulates the stability of nascent NPC2, thereby promoting trafficking of LDL-derived cholesterol	receptor accessory protein 5; May promote functional cell surface expression of olfactory receptors	0.680
NUS1	RTN2	ENSP00000357480	ENSP00000245923	nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae); Acts as a specific receptor for the N-terminus of Nogo- B, a neural and cardiovascular regulator. Regulates the stability of nascent NPC2, thereby promoting trafficking of LDL-derived cholesterol	reticulon 2	0.661
REEP1	ATL1	ENSP00000438346	ENSP00000351155	receptor accessory protein 1; Required for endoplasmic reticulum (ER) network formation, shaping and remodeling; it links ER tubules to the cytoskeleton. May also enhance the cell surface expression of odorant receptors	atlastin GTPase 1; GTPase tethering membranes through formation of trans- homooligomer and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. May also regulate Golgi biogenesis. May regulate axonal development	0.948
REEP1	KIAA0196	ENSP00000438346	ENSP00000318016	receptor accessory protein 1; Required for endoplasmic reticulum (ER) network formation, shaping and remodeling; it links ER tubules to the cytoskeleton. May also enhance the cell surface expression of odorant receptors	KIAA0196; Component of the WASH complex, a complex present at the surface of endosomes that recruits and activates the Arp2/3 complex to induce actin polymerization. The WASH complex plays a key role in the fission of tubules that serve as transport intermediates during endosome sorting	0.743
REEP1	RTN2	ENSP00000438346	ENSP00000245923	receptor accessory protein 1; Required for endoplasmic reticulum (ER) network formation, shaping and remodeling; it links ER tubules to the cytoskeleton. May also enhance the cell surface expression of odorant receptors	reticulon 2	0.648
REEP1	SPAST	ENSP00000438346	ENSP00000320885	receptor accessory protein 1; Required for endoplasmic reticulum (ER) network formation, shaping and remodeling; it links ER tubules to the cytoskeleton. May also enhance the cell surface expression of odorant receptors	spastin; ATP-dependent microtubule severing protein. Microtubule severing may promote reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Required for membrane traffic from the endoplasmic reticulum (ER) to the Golgi and for completion of the abscission stage of cytokinesis. Also plays a role in axon growth and the formation of axonal branches (By similarity)	0.741
REEP5	ATL1	ENSP00000368959	ENSP00000351155	receptor accessory protein 5; May promote functional cell surface expression of olfactory receptors	atlastin GTPase 1; GTPase tethering membranes through formation of trans- homooligomer and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. May also regulate Golgi biogenesis. May regulate axonal development	0.533
REEP5	NUS1	ENSP00000368959	ENSP00000357480	receptor accessory protein 5; May promote functional cell surface expression of olfactory receptors	nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae); Acts as a specific receptor for the N-terminus of Nogo- B, a neural and cardiovascular regulator. Regulates the stability of nascent NPC2, thereby promoting trafficking of LDL-derived cholesterol	0.680
REEP5	RTN2	ENSP00000368959	ENSP00000245923	receptor accessory protein 5; May promote functional cell surface expression of olfactory receptors	reticulon 2	0.728

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