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TWF1 TWF1 WDR1 WDR1 CAP1 CAP1 ACTA1 ACTA1 CAP2 CAP2 ACTG1 ACTG1 UBC UBC ACTRT1 ACTRT1 DSTN DSTN ACTB ACTB TPM2 TPM2
"DSTN" - destrin (actin depolymerizing factor) in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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second shell of interactors
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experimentally determined
Predicted Interactions
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protein homology
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Score
DSTNdestrin (actin depolymerizing factor); Actin-depolymerizing protein. Severs actin filaments (F- actin) and binds to actin monomers (G-actin). Acts in a pH- independent manner (165 aa)    
Predicted Functional Partners:
ACTB
actin, beta (375 aa)
      score_image score_image   score_image   0.987
ACTG1
actin, gamma 1; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells (375 aa)
      score_image score_image   score_image   0.986
UBC
ubiquitin C (685 aa)
        score_image   score_image   0.969
WDR1
WD repeat domain 1; Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins (By similarity) (606 aa)
        score_image   score_image   0.963
TWF1
twinfilin, actin-binding protein, homolog 1 (Drosophila) (357 aa)
        score_image   score_image   0.922
TPM2
tropomyosin 2 (beta); Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. The non-muscle isoform may have a role in agonist-mediated receptor internalization (By similarity) (284 aa)
      score_image score_image   score_image   0.914
ACTA1
actin, alpha 1, skeletal muscle; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells (377 aa)
      score_image score_image   score_image   0.911
CAP2
CAP, adenylate cyclase-associated protein, 2 (yeast); May have a regulatory bifunctional role (477 aa)
      score_image score_image   score_image   0.909
CAP1
CAP, adenylate cyclase-associated protein 1 (yeast); Directly regulates filament dynamics and has been implicated in a number of complex developmental and morphological processes, including mRNA localization and the establishment of cell polarity (475 aa)
      score_image score_image   score_image   0.908
ACTRT1
actin-related protein T1 (376 aa)
      score_image score_image   score_image   0.845
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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