FNTB protein (Homo sapiens) - STRING network view

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FNTB

farnesyltransferase, CAAX box, beta; Catalyzes the transfer of a farnesyl moiety from farnesyl pyrophosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding (437 aa)

Predicted Functional Partners:

FNTA

0.999

ENSG00000254673

0.974

ZMPSTE24

0.960

RCE1

0.953

GGPS1

0.951

FDPS

0.938

PDSS1

0.919

PDSS2

0.919

ENSG00000125954

0.900

DHDDS

0.900

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DHDDS	ENSG00000254673	ENSP00000353104	ENSP00000435061	dehydrodolichyl diphosphate synthase	Uncharacterized protein	0.900
DHDDS	FDPS	ENSP00000353104	ENSP00000349078	dehydrodolichyl diphosphate synthase	farnesyl diphosphate synthase; Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate	0.956
DHDDS	FNTB	ENSP00000353104	ENSP00000246166	dehydrodolichyl diphosphate synthase	farnesyltransferase, CAAX box, beta; Catalyzes the transfer of a farnesyl moiety from farnesyl pyrophosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding	0.900
DHDDS	GGPS1	ENSP00000353104	ENSP00000282841	dehydrodolichyl diphosphate synthase	geranylgeranyl diphosphate synthase 1; Catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate, an important precursor of carotenoids and geranylated proteins	0.930
DHDDS	PDSS1	ENSP00000353104	ENSP00000365388	dehydrodolichyl diphosphate synthase	prenyl (decaprenyl) diphosphate synthase, subunit 1; Supplies decaprenyl diphosphate, the precursor for the side chain of the isoprenoid quinones ubiquinone-10	0.933
DHDDS	PDSS2	ENSP00000353104	ENSP00000358033	dehydrodolichyl diphosphate synthase	prenyl (decaprenyl) diphosphate synthase, subunit 2; Supplies decaprenyl diphosphate, the precursor for the side chain of the isoprenoid quinones ubiquinone-10	0.930
ENSG00000125954	ENSG00000254673	ENSP00000443140	ENSP00000435061	CHURC1-FNTB readthrough	Uncharacterized protein	0.879
ENSG00000125954	FNTA	ENSP00000443140	ENSP00000303423	CHURC1-FNTB readthrough	farnesyltransferase, CAAX box, alpha; Catalyzes the transfer of a farnesyl or geranyl-geranyl moiety from farnesyl or geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. The alpha subunit is thought to participate in a stable complex with the substrate. The beta subunit binds the peptide substrate. Through RAC1 prenylation and activation may positively regulate neuromuscular junction development downstream of MUSK (By similarity)	0.996
ENSG00000125954	FNTB	ENSP00000443140	ENSP00000246166	CHURC1-FNTB readthrough	farnesyltransferase, CAAX box, beta; Catalyzes the transfer of a farnesyl moiety from farnesyl pyrophosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding	0.900
ENSG00000125954	GGPS1	ENSP00000443140	ENSP00000282841	CHURC1-FNTB readthrough	geranylgeranyl diphosphate synthase 1; Catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate, an important precursor of carotenoids and geranylated proteins	0.414
ENSG00000125954	RCE1	ENSP00000443140	ENSP00000309163	CHURC1-FNTB readthrough	RCE1 homolog, prenyl protein protease (S. cerevisiae); Proteolytically removes the C-terminal three residues of farnesylated and geranylated proteins. Seems to be able to process K-Ras, N-Ras, H-Ras, RAP1B and G-gamma-1	0.554
ENSG00000125954	ZMPSTE24	ENSP00000443140	ENSP00000361845	CHURC1-FNTB readthrough	zinc metallopeptidase STE24 homolog (S. cerevisiae); Proteolytically removes the C-terminal three residues of farnesylated proteins. Acts on lamin A/C	0.543
ENSG00000254673	DHDDS	ENSP00000435061	ENSP00000353104	Uncharacterized protein	dehydrodolichyl diphosphate synthase	0.900
ENSG00000254673	ENSG00000125954	ENSP00000435061	ENSP00000443140	Uncharacterized protein	CHURC1-FNTB readthrough	0.879
ENSG00000254673	FDPS	ENSP00000435061	ENSP00000349078	Uncharacterized protein	farnesyl diphosphate synthase; Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate	0.907
ENSG00000254673	FNTB	ENSP00000435061	ENSP00000246166	Uncharacterized protein	farnesyltransferase, CAAX box, beta; Catalyzes the transfer of a farnesyl moiety from farnesyl pyrophosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding	0.974
ENSG00000254673	GGPS1	ENSP00000435061	ENSP00000282841	Uncharacterized protein	geranylgeranyl diphosphate synthase 1; Catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate, an important precursor of carotenoids and geranylated proteins	0.907
ENSG00000254673	PDSS1	ENSP00000435061	ENSP00000365388	Uncharacterized protein	prenyl (decaprenyl) diphosphate synthase, subunit 1; Supplies decaprenyl diphosphate, the precursor for the side chain of the isoprenoid quinones ubiquinone-10	0.907
ENSG00000254673	PDSS2	ENSP00000435061	ENSP00000358033	Uncharacterized protein	prenyl (decaprenyl) diphosphate synthase, subunit 2; Supplies decaprenyl diphosphate, the precursor for the side chain of the isoprenoid quinones ubiquinone-10	0.907
ENSG00000254673	RCE1	ENSP00000435061	ENSP00000309163	Uncharacterized protein	RCE1 homolog, prenyl protein protease (S. cerevisiae); Proteolytically removes the C-terminal three residues of farnesylated and geranylated proteins. Seems to be able to process K-Ras, N-Ras, H-Ras, RAP1B and G-gamma-1	0.935

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