BCL2L12 protein (Homo sapiens) - STRING network view

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BCL2L12

BCL2-like 12 (proline rich) (334 aa)

Predicted Functional Partners:

BCL2L1

0.932

TP53

0.859

UBC

0.837

GSK3B

0.779

RRAS

0.681

GSK3A

0.676

CASP7

0.607

HSPA4

0.576

PRMT1

0.561

ENSG00000268643

0.518

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BCL2L1	BCL2L12	ENSP00000302564	ENSP00000246785	BCL2-like 1; Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis	BCL2-like 12 (proline rich)	0.932
BCL2L1	CASP7	ENSP00000302564	ENSP00000358327	BCL2-like 1; Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis	caspase 7, apoptosis-related cysteine peptidase	0.907
BCL2L1	GSK3B	ENSP00000302564	ENSP00000324806	BCL2-like 1; Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis	glycogen synthase kinase 3 beta; Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), EIF2B, CTNNB1/beta-catenin, APC, AXIN1, DPYSL2/CRMP2, JUN, NFATC1/NFATC, MAPT/TAU and MACF1. Requires primed phosphorylation of the majority of its substrates. In skeletal muscle, contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glyc [...]	0.525
BCL2L1	TP53	ENSP00000302564	ENSP00000269305	BCL2-like 1; Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis	tumor protein p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity)	0.999
BCL2L1	UBC	ENSP00000302564	ENSP00000344818	BCL2-like 1; Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis	ubiquitin C	0.983
BCL2L12	BCL2L1	ENSP00000246785	ENSP00000302564	BCL2-like 12 (proline rich)	BCL2-like 1; Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis	0.932
BCL2L12	CASP7	ENSP00000246785	ENSP00000358327	BCL2-like 12 (proline rich)	caspase 7, apoptosis-related cysteine peptidase	0.607
BCL2L12	ENSG00000268643	ENSP00000246785	ENSP00000470087	BCL2-like 12 (proline rich)	Uncharacterized protein	0.518
BCL2L12	GSK3A	ENSP00000246785	ENSP00000222330	BCL2-like 12 (proline rich)	glycogen synthase kinase 3 alpha; Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), CTNNB1/beta-catenin, APC and AXIN1. Requires primed phosphorylation of the majority of its substrates. Contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. Regulates glycogen metabolism in liver, but not in muscle. M [...]	0.676
BCL2L12	GSK3B	ENSP00000246785	ENSP00000324806	BCL2-like 12 (proline rich)	glycogen synthase kinase 3 beta; Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), EIF2B, CTNNB1/beta-catenin, APC, AXIN1, DPYSL2/CRMP2, JUN, NFATC1/NFATC, MAPT/TAU and MACF1. Requires primed phosphorylation of the majority of its substrates. In skeletal muscle, contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glyc [...]	0.779
BCL2L12	HSPA4	ENSP00000246785	ENSP00000302961	BCL2-like 12 (proline rich)	heat shock 70kDa protein 4	0.576
BCL2L12	PRMT1	ENSP00000246785	ENSP00000406162	BCL2-like 12 (proline rich)	protein arginine methyltransferase 1	0.561
BCL2L12	RRAS	ENSP00000246785	ENSP00000246792	BCL2-like 12 (proline rich)	related RAS viral (r-ras) oncogene homolog; Regulates the organization of the actin cytoskeleton	0.681
BCL2L12	TP53	ENSP00000246785	ENSP00000269305	BCL2-like 12 (proline rich)	tumor protein p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity)	0.859
BCL2L12	UBC	ENSP00000246785	ENSP00000344818	BCL2-like 12 (proline rich)	ubiquitin C	0.837
CASP7	BCL2L1	ENSP00000358327	ENSP00000302564	caspase 7, apoptosis-related cysteine peptidase	BCL2-like 1; Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis	0.907
CASP7	BCL2L12	ENSP00000358327	ENSP00000246785	caspase 7, apoptosis-related cysteine peptidase	BCL2-like 12 (proline rich)	0.607
CASP7	TP53	ENSP00000358327	ENSP00000269305	caspase 7, apoptosis-related cysteine peptidase	tumor protein p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity)	0.860
CASP7	UBC	ENSP00000358327	ENSP00000344818	caspase 7, apoptosis-related cysteine peptidase	ubiquitin C	0.869
ENSG00000268643	BCL2L12	ENSP00000470087	ENSP00000246785	Uncharacterized protein	BCL2-like 12 (proline rich)	0.518

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