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STRINGSTRING
HTN1 HTN1 MUC7 MUC7 MUC5B MUC5B PROL1 PROL1 HTN3 HTN3 CST4 CST4 STATH STATH ASNA1 ASNA1 UCP3 UCP3 CTRC CTRC RPL14 RPL14
"STATH" - statherin in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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Predicted Interactions
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STATHstatherin; Salivary protein that stabilizes saliva supersaturated with calcium salts by inhibiting the precipitation of calcium phosphate salts. It also modulates hydroxyapatite crystal formation on the tooth surface (62 aa)    
Predicted Functional Partners:
HTN1
histatin 1; Histatins are salivary proteins that are considered to be major precursors of the protective proteinaceous structure on tooth surfaces (enamel pellicle). In addition, histatins exhibit antibacterial and antifungal activities (57 aa)
             score_image   0.866
UCP3
uncoupling protein 3 (mitochondrial, proton carrier); UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation. As a result, energy is dissipated in the form of heat. May play a role in the modulation of tissue respiratory control. Participates in thermogenesis and energy balance (312 aa)
             score_image   0.800
MUC5B
mucin 5B, oligomeric mucus/gel-forming (5762 aa)
         score_image   score_image   0.739
MUC7
mucin 7, secreted; May function in a protective capacity by promoting the clearance of bacteria in the oral cavity and aiding in mastication, speech, and swallowing. Binds P.aeruginosa pili (377 aa)
         score_image   score_image   0.734
CST4
cystatin S; This protein strongly inhibits papain and ficin, partially inhibits stem bromelain and bovine cathepsin C, but does not inhibit porcine cathepsin B or clostripain. Papain is inhibited non-competitively (141 aa)
             score_image   0.659
RPL14
ribosomal protein L14 (215 aa)
             score_image   0.609
CTRC
chymotrypsin C (caldecrin); Has chymotrypsin-type protease activity and hypocalcemic activity (268 aa)
             score_image   0.608
ASNA1
arsA arsenite transporter, ATP-binding, homolog 1 (bacterial); ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail- anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane pro [...] (348 aa)
         score_image   score_image   0.606
HTN3
histatin 3; Histatins are salivary proteins that are considered to be major precursors of the protective proteinaceous structure on tooth surfaces (enamel pellicle). In addition, histatins exhibit antibacterial and antifungal activities. His3-(20-43)-peptide (histatin-5) is especially effective against C.albicans and C.neoformans, and inhibits Lys-gingipain and Arg-gingipain (rgpB) from P.gingivalis. In addition, His3-(20-43)-peptide is a potent inhibitor of metalloproteinases MMP2 and MMP9 (51 aa)
             score_image   0.583
PROL1
proline rich, lacrimal 1; Opiorphin is an endogenous inhibitor of neprilysin and aminopeptidase N. Inhibits the breakdown of substance P, Mca-BK2 and Met-enkephalin by neprilysin in vitro with IC(50) values of 29 uM, 33 uM and 33 uM respectively. Inhibits the breakdown of Ala- pNA by aminopeptidase N in vitro with an IC(50) of 65 uM. Has a potent analgesic effect when administered to rats by intravenous injection (248 aa)
         score_image       0.576
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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