TRAP1 protein (Homo sapiens) - STRING network view

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TRAP1

TNF receptor-associated protein 1; Chaperone that expresses an ATPase activity (704 aa)

Predicted Functional Partners:

SUGT1

0.997

UBC

0.987

PINK1

0.977

SF3A2

0.966

STIP1

0.966

SUGT1P3

0.960

TTC12

0.960

TTC28

0.960

TTC31

0.960

PTGES3

0.948

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
PINK1	TRAP1	ENSP00000364204	ENSP00000246957	PTEN induced putative kinase 1; Protects against mitochondrial dysfunction during cellular stress, potentially by phosphorylating mitochondrial proteins. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy). It is necessary for PARK2 recruitment to dysfunctional mitochondria to initiate their degradation	TNF receptor-associated protein 1; Chaperone that expresses an ATPase activity	0.977
PINK1	UBC	ENSP00000364204	ENSP00000344818	PTEN induced putative kinase 1; Protects against mitochondrial dysfunction during cellular stress, potentially by phosphorylating mitochondrial proteins. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy). It is necessary for PARK2 recruitment to dysfunctional mitochondria to initiate their degradation	ubiquitin C	0.999
PTGES3	STIP1	ENSP00000262033	ENSP00000305958	prostaglandin E synthase 3 (cytosolic); Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor- mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes	stress-induced-phosphoprotein 1; Mediates the association of the molecular chaperones HSC70 and HSP90 (HSPCA and HSPCB)	0.985
PTGES3	SUGT1	ENSP00000262033	ENSP00000367208	prostaglandin E synthase 3 (cytosolic); Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor- mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes	SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae); May play a role in ubiquitination and subsequent proteasomal degradation of target proteins	0.978
PTGES3	SUGT1P3	ENSP00000262033	ENSP00000434236	prostaglandin E synthase 3 (cytosolic); Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor- mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes	suppressor of G2 allele of SKP1 (S. cerevisiae) pseudogene 3	0.918
PTGES3	TRAP1	ENSP00000262033	ENSP00000246957	prostaglandin E synthase 3 (cytosolic); Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor- mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes	TNF receptor-associated protein 1; Chaperone that expresses an ATPase activity	0.948
PTGES3	TTC12	ENSP00000262033	ENSP00000433757	prostaglandin E synthase 3 (cytosolic); Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor- mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes	tetratricopeptide repeat domain 12	0.918
PTGES3	TTC28	ENSP00000262033	ENSP00000381003	prostaglandin E synthase 3 (cytosolic); Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor- mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes	tetratricopeptide repeat domain 28	0.918
PTGES3	TTC31	ENSP00000262033	ENSP00000233623	prostaglandin E synthase 3 (cytosolic); Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor- mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes	tetratricopeptide repeat domain 31	0.918
PTGES3	UBC	ENSP00000262033	ENSP00000344818	prostaglandin E synthase 3 (cytosolic); Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor- mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes	ubiquitin C	0.889
SF3A2	TRAP1	ENSP00000221494	ENSP00000246957	splicing factor 3a, subunit 2, 66kDa; Subunit of the splicing factor SF3A required for ’A’ complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the ’E’ complex	TNF receptor-associated protein 1; Chaperone that expresses an ATPase activity	0.966
SF3A2	UBC	ENSP00000221494	ENSP00000344818	splicing factor 3a, subunit 2, 66kDa; Subunit of the splicing factor SF3A required for ’A’ complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the ’E’ complex	ubiquitin C	0.800
STIP1	PTGES3	ENSP00000305958	ENSP00000262033	stress-induced-phosphoprotein 1; Mediates the association of the molecular chaperones HSC70 and HSP90 (HSPCA and HSPCB)	prostaglandin E synthase 3 (cytosolic); Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor- mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes	0.985
STIP1	SUGT1	ENSP00000305958	ENSP00000367208	stress-induced-phosphoprotein 1; Mediates the association of the molecular chaperones HSC70 and HSP90 (HSPCA and HSPCB)	SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae); May play a role in ubiquitination and subsequent proteasomal degradation of target proteins	0.698
STIP1	TRAP1	ENSP00000305958	ENSP00000246957	stress-induced-phosphoprotein 1; Mediates the association of the molecular chaperones HSC70 and HSP90 (HSPCA and HSPCB)	TNF receptor-associated protein 1; Chaperone that expresses an ATPase activity	0.966
STIP1	UBC	ENSP00000305958	ENSP00000344818	stress-induced-phosphoprotein 1; Mediates the association of the molecular chaperones HSC70 and HSP90 (HSPCA and HSPCB)	ubiquitin C	0.989
SUGT1	PTGES3	ENSP00000367208	ENSP00000262033	SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae); May play a role in ubiquitination and subsequent proteasomal degradation of target proteins	prostaglandin E synthase 3 (cytosolic); Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor- mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes	0.978
SUGT1	STIP1	ENSP00000367208	ENSP00000305958	SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae); May play a role in ubiquitination and subsequent proteasomal degradation of target proteins	stress-induced-phosphoprotein 1; Mediates the association of the molecular chaperones HSC70 and HSP90 (HSPCA and HSPCB)	0.698
SUGT1	SUGT1P3	ENSP00000367208	ENSP00000434236	SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae); May play a role in ubiquitination and subsequent proteasomal degradation of target proteins	suppressor of G2 allele of SKP1 (S. cerevisiae) pseudogene 3	0.412
SUGT1	TRAP1	ENSP00000367208	ENSP00000246957	SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae); May play a role in ubiquitination and subsequent proteasomal degradation of target proteins	TNF receptor-associated protein 1; Chaperone that expresses an ATPase activity	0.997

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