DDX49 protein (Homo sapiens) - STRING network view

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DDX49

DEAD (Asp-Glu-Ala-Asp) box polypeptide 49 (483 aa)

Predicted Functional Partners:

NOP2

0.934

PNO1

0.900

DDX55

0.889

TSR1

0.889

FTSJ3

0.887

NOC2L

0.887

WDR12

0.872

RPF2

0.865

RRP1

0.858

BRIX1

0.854

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BRIX1	DDX49	ENSP00000338862	ENSP00000247003	BRX1, biogenesis of ribosomes, homolog (S. cerevisiae); Required for biogenesis of the 60S ribosomal subunit	DEAD (Asp-Glu-Ala-Asp) box polypeptide 49	0.854
BRIX1	DDX55	ENSP00000338862	ENSP00000238146	BRX1, biogenesis of ribosomes, homolog (S. cerevisiae); Required for biogenesis of the 60S ribosomal subunit	DEAD (Asp-Glu-Ala-Asp) box polypeptide 55; Probable ATP-binding RNA helicase	0.950
BRIX1	FTSJ3	ENSP00000338862	ENSP00000396673	BRX1, biogenesis of ribosomes, homolog (S. cerevisiae); Required for biogenesis of the 60S ribosomal subunit	FtsJ homolog 3 (E. coli); Probable methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation	0.930
BRIX1	NOC2L	ENSP00000338862	ENSP00000317992	BRX1, biogenesis of ribosomes, homolog (S. cerevisiae); Required for biogenesis of the 60S ribosomal subunit	nucleolar complex associated 2 homolog (S. cerevisiae); Acts as an inhibitor of histone acetyltransferase activity; prevents acetylation of all core histones by the EP300/p300 histone acetyltransferase at p53/TP53-regulated target promoters in a histone deacetylases (HDAC)-independent manner. Acts as a transcription corepressor of p53/TP53- and TP63-mediated transactivation of the p21/CDKN1A promoter. Involved in the regulation of p53/TP53-dependent apoptosis. Associates together with TP63 isoform TA*-gamma to the p21/CDKN1A promoter	0.993
BRIX1	NOP2	ENSP00000338862	ENSP00000382392	BRX1, biogenesis of ribosomes, homolog (S. cerevisiae); Required for biogenesis of the 60S ribosomal subunit	NOP2 nucleolar protein homolog (yeast); May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation. May act as ribosomal RNA methyltransferase	0.994
BRIX1	PNO1	ENSP00000338862	ENSP00000263657	BRX1, biogenesis of ribosomes, homolog (S. cerevisiae); Required for biogenesis of the 60S ribosomal subunit	partner of NOB1 homolog (S. cerevisiae)	0.873
BRIX1	RPF2	ENSP00000338862	ENSP00000402338	BRX1, biogenesis of ribosomes, homolog (S. cerevisiae); Required for biogenesis of the 60S ribosomal subunit	ribosome production factor 2 homolog (S. cerevisiae)	0.998
BRIX1	RRP1	ENSP00000338862	ENSP00000417464	BRX1, biogenesis of ribosomes, homolog (S. cerevisiae); Required for biogenesis of the 60S ribosomal subunit	ribosomal RNA processing 1 homolog (S. cerevisiae); Plays a critical role in the generation of 28S rRNA	0.977
BRIX1	TSR1	ENSP00000338862	ENSP00000301364	BRX1, biogenesis of ribosomes, homolog (S. cerevisiae); Required for biogenesis of the 60S ribosomal subunit	TSR1, 20S rRNA accumulation, homolog (S. cerevisiae); Required during maturation of the 40S ribosomal subunit in the nucleolus (By similarity)	0.957
BRIX1	WDR12	ENSP00000338862	ENSP00000261015	BRX1, biogenesis of ribosomes, homolog (S. cerevisiae); Required for biogenesis of the 60S ribosomal subunit	WD repeat domain 12; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome	0.998
DDX49	BRIX1	ENSP00000247003	ENSP00000338862	DEAD (Asp-Glu-Ala-Asp) box polypeptide 49	BRX1, biogenesis of ribosomes, homolog (S. cerevisiae); Required for biogenesis of the 60S ribosomal subunit	0.854
DDX49	DDX55	ENSP00000247003	ENSP00000238146	DEAD (Asp-Glu-Ala-Asp) box polypeptide 49	DEAD (Asp-Glu-Ala-Asp) box polypeptide 55; Probable ATP-binding RNA helicase	0.889
DDX49	FTSJ3	ENSP00000247003	ENSP00000396673	DEAD (Asp-Glu-Ala-Asp) box polypeptide 49	FtsJ homolog 3 (E. coli); Probable methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation	0.887
DDX49	NOC2L	ENSP00000247003	ENSP00000317992	DEAD (Asp-Glu-Ala-Asp) box polypeptide 49	nucleolar complex associated 2 homolog (S. cerevisiae); Acts as an inhibitor of histone acetyltransferase activity; prevents acetylation of all core histones by the EP300/p300 histone acetyltransferase at p53/TP53-regulated target promoters in a histone deacetylases (HDAC)-independent manner. Acts as a transcription corepressor of p53/TP53- and TP63-mediated transactivation of the p21/CDKN1A promoter. Involved in the regulation of p53/TP53-dependent apoptosis. Associates together with TP63 isoform TA*-gamma to the p21/CDKN1A promoter	0.887
DDX49	NOP2	ENSP00000247003	ENSP00000382392	DEAD (Asp-Glu-Ala-Asp) box polypeptide 49	NOP2 nucleolar protein homolog (yeast); May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation. May act as ribosomal RNA methyltransferase	0.934
DDX49	PNO1	ENSP00000247003	ENSP00000263657	DEAD (Asp-Glu-Ala-Asp) box polypeptide 49	partner of NOB1 homolog (S. cerevisiae)	0.900
DDX49	RPF2	ENSP00000247003	ENSP00000402338	DEAD (Asp-Glu-Ala-Asp) box polypeptide 49	ribosome production factor 2 homolog (S. cerevisiae)	0.865
DDX49	RRP1	ENSP00000247003	ENSP00000417464	DEAD (Asp-Glu-Ala-Asp) box polypeptide 49	ribosomal RNA processing 1 homolog (S. cerevisiae); Plays a critical role in the generation of 28S rRNA	0.858
DDX49	TSR1	ENSP00000247003	ENSP00000301364	DEAD (Asp-Glu-Ala-Asp) box polypeptide 49	TSR1, 20S rRNA accumulation, homolog (S. cerevisiae); Required during maturation of the 40S ribosomal subunit in the nucleolus (By similarity)	0.889
DDX49	WDR12	ENSP00000247003	ENSP00000261015	DEAD (Asp-Glu-Ala-Asp) box polypeptide 49	WD repeat domain 12; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome	0.872

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