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BRF1 BRF1 TAF1L TAF1L TAF6 TAF6 TAF2 TAF2 GTF2A2 GTF2A2 TAF1 TAF1 TBPL2 TBPL2 TAF3 TAF3 BRF2 BRF2 GTF2B GTF2B DR1 DR1
"TBPL2" - TATA box binding protein like 2 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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query proteins and first shell of interactors
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second shell of interactors
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protein homology
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TBPL2TATA box binding protein like 2; Transcription factor required in complex with TAF3 for the differentiation of myoblasts into myocytes. The complex replaces TFIID at specific promoters at an early stage in the differentiation process (By similarity) (375 aa)    
Predicted Functional Partners:
GTF2B
general transcription factor IIB; General factor that plays a major role in the activation of eukaryotic genes transcribed by RNA polymerase II (316 aa)
      score_image score_image   score_image   0.994
BRF1
BRF1 homolog, subunit of RNA polymerase III transcription initiation factor IIIB (S. cerevisiae) (677 aa)
      score_image score_image   score_image   0.991
TAF3
TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa; Transcription factor TFIID is one of the general factors required for accurate and regulated initiation by RNA polymerase II. TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. Required in complex with TBPL2 for the differentiation of myoblasts into myocytes. The complex replaces TFIID at specific promoters at an early stage in the differentiation process (929 aa)
        score_image   score_image   0.979
GTF2A2
general transcription factor IIA, 2, 12kDa; TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity (109 aa)
      score_image score_image   score_image   0.979
BRF2
BRF2, subunit of RNA polymerase III transcription initiation factor, BRF1-like; General activator of RNA polymerase III transcription. Factor exclusively required for RNA polymerase III transcription of genes with promoter elements upstream of the initiation sites (419 aa)
      score_image score_image   score_image   0.977
TAF1
TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa (1893 aa)
        score_image   score_image   0.971
TAF1L
TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like; May act as a functional substitute for TAF1/TAFII250 during male meiosis, when sex chromosomes are transcriptionally silenced (1826 aa)
        score_image   score_image   0.968
DR1
down-regulator of transcription 1, TBP-binding (negative cofactor 2); The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 (176 aa)
        score_image   score_image   0.962
TAF6
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa; TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TIIFD is multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors (714 aa)
        score_image   score_image   0.959
TAF2
TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa; Transcription factor TFIID is one of the general factors required for accurate and regulated initiation by RNA polymerase II. TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. It requires core promoter-specific cofactors for productive transcription stimulation. TAF2 stabilizes TFIID binding to core promoter (1199 aa)
        score_image   score_image   0.958
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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