PLEKHG3 protein (Homo sapiens) - STRING network view

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PLEKHG3

pleckstrin homology domain containing, family G (with RhoGef domain) member 3 (1163 aa)

Predicted Functional Partners:

SPTB

0.505

GNG2

0.499

FAM132B

0.495

UBC

0.483

SUPT5H

0.446

CHURC1

0.414

ABCB10

0.410

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABCB10	PLEKHG3	ENSP00000355637	ENSP00000247226	ATP-binding cassette, sub-family B (MDR/TAP), member 10; May mediate critical mitochondrial transport functions related to heme biosynthesis (By similarity)	pleckstrin homology domain containing, family G (with RhoGef domain) member 3	0.410
ABCB10	UBC	ENSP00000355637	ENSP00000344818	ATP-binding cassette, sub-family B (MDR/TAP), member 10; May mediate critical mitochondrial transport functions related to heme biosynthesis (By similarity)	ubiquitin C	0.654
CHURC1	PLEKHG3	ENSP00000450144	ENSP00000247226	churchill domain containing 1; Transcriptional activator that mediates FGF signaling during neural development. Plays a role in the regulation of cell movement (By similarity). Does not bind DNA by itself	pleckstrin homology domain containing, family G (with RhoGef domain) member 3	0.414
FAM132B	PLEKHG3	ENSP00000442304	ENSP00000247226	family with sequence similarity 132, member B; Promotes lipid uptake into adipocytes and hepatocytes via transcriptional up-regulation of genes involved in fatty acid uptake (By similarity)	pleckstrin homology domain containing, family G (with RhoGef domain) member 3	0.495
GNG2	PLEKHG3	ENSP00000334448	ENSP00000247226	guanine nucleotide binding protein (G protein), gamma 2; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction (By similarity)	pleckstrin homology domain containing, family G (with RhoGef domain) member 3	0.499
GNG2	UBC	ENSP00000334448	ENSP00000344818	guanine nucleotide binding protein (G protein), gamma 2; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction (By similarity)	ubiquitin C	0.494
PLEKHG3	ABCB10	ENSP00000247226	ENSP00000355637	pleckstrin homology domain containing, family G (with RhoGef domain) member 3	ATP-binding cassette, sub-family B (MDR/TAP), member 10; May mediate critical mitochondrial transport functions related to heme biosynthesis (By similarity)	0.410
PLEKHG3	CHURC1	ENSP00000247226	ENSP00000450144	pleckstrin homology domain containing, family G (with RhoGef domain) member 3	churchill domain containing 1; Transcriptional activator that mediates FGF signaling during neural development. Plays a role in the regulation of cell movement (By similarity). Does not bind DNA by itself	0.414
PLEKHG3	FAM132B	ENSP00000247226	ENSP00000442304	pleckstrin homology domain containing, family G (with RhoGef domain) member 3	family with sequence similarity 132, member B; Promotes lipid uptake into adipocytes and hepatocytes via transcriptional up-regulation of genes involved in fatty acid uptake (By similarity)	0.495
PLEKHG3	GNG2	ENSP00000247226	ENSP00000334448	pleckstrin homology domain containing, family G (with RhoGef domain) member 3	guanine nucleotide binding protein (G protein), gamma 2; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction (By similarity)	0.499
PLEKHG3	SPTB	ENSP00000247226	ENSP00000374372	pleckstrin homology domain containing, family G (with RhoGef domain) member 3	spectrin, beta, erythrocytic; Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane	0.505
PLEKHG3	SUPT5H	ENSP00000247226	ENSP00000404029	pleckstrin homology domain containing, family G (with RhoGef domain) member 3	suppressor of Ty 5 homolog (S. cerevisiae); Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II. DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A. DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter. Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF and NELF promot [...]	0.446
PLEKHG3	UBC	ENSP00000247226	ENSP00000344818	pleckstrin homology domain containing, family G (with RhoGef domain) member 3	ubiquitin C	0.483
SPTB	PLEKHG3	ENSP00000374372	ENSP00000247226	spectrin, beta, erythrocytic; Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane	pleckstrin homology domain containing, family G (with RhoGef domain) member 3	0.505
SPTB	SUPT5H	ENSP00000374372	ENSP00000404029	spectrin, beta, erythrocytic; Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane	suppressor of Ty 5 homolog (S. cerevisiae); Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II. DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A. DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter. Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF and NELF promot [...]	0.429
SPTB	UBC	ENSP00000374372	ENSP00000344818	spectrin, beta, erythrocytic; Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane	ubiquitin C	0.663
SUPT5H	PLEKHG3	ENSP00000404029	ENSP00000247226	suppressor of Ty 5 homolog (S. cerevisiae); Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II. DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A. DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter. Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF and NELF promot [...]	pleckstrin homology domain containing, family G (with RhoGef domain) member 3	0.446
SUPT5H	SPTB	ENSP00000404029	ENSP00000374372	suppressor of Ty 5 homolog (S. cerevisiae); Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II. DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A. DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter. Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF and NELF promot [...]	spectrin, beta, erythrocytic; Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane	0.429
SUPT5H	UBC	ENSP00000404029	ENSP00000344818	suppressor of Ty 5 homolog (S. cerevisiae); Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II. DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A. DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter. Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF and NELF promot [...]	ubiquitin C	0.938
UBC	ABCB10	ENSP00000344818	ENSP00000355637	ubiquitin C	ATP-binding cassette, sub-family B (MDR/TAP), member 10; May mediate critical mitochondrial transport functions related to heme biosynthesis (By similarity)	0.654

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