Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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Neighborhood |
Gene Fusion |
Cooccurence |
Coexpression |
Experiments |
Databases |
Textmining |
[Homology] |
Score |
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 | PHPT1 | phosphohistidine phosphatase 1; Exhibits phosphohistidine phosphatase activity (125 aa) | ||||||||||||
Predicted Functional Partners:
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 | KCNN4 | potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4; Forms a voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization which promotes calcium influx. Required for maximal calcium influx and proliferation during the reactivation of naive T-cells. The channel is blocked by clotrimazole and charybdotoxin but is insensitive to apamin (427 aa) |
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0.940 | |||||||||
 | HK1 | hexokinase 1 (921 aa) |
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0.900 | ||||||||||
 | HKDC1 | hexokinase domain containing 1 (917 aa) |
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0.900 | ||||||||||
 | HK3 | hexokinase 3 (white cell) (923 aa) |
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0.900 | ||||||||||
 | HK2 | hexokinase 2 (917 aa) |
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0.900 | ||||||||||
 | SORD | sorbitol dehydrogenase; Converts sorbitol to fructose. Part of the polyol pathway that plays an important role in sperm physiology. May play a role in the sperm motility by providing an energetic source for sperm (By similarity) (357 aa) |
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0.900 | ||||||||||
 | KHK | ketohexokinase (fructokinase) (298 aa) |
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0.900 | ||||||||||
 | FUK | fucokinase; Takes part in the salvage pathway for reutilization of fucose from the degradation of oligosaccharides (1084 aa) |
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0.800 | ||||||||||
 | DNMT3L | DNA (cytosine-5-)-methyltransferase 3-like; Catalytically inactive regulatory factor of DNA methyltransferases. It is essential for the function of DNMT3A and DNMT3B. Activates DNMT3A and DNMT3B by binding to their catalytic domain. Accelerates the binding of DNA and AdoMet to the methyltransferases and dissociates from the complex after DNA binding to the methyltransferases. Recognizes unmethylated histone H3 lysine 4 (H3K4) and induces de novo DNA methylation by recruitment or activation of DNMT3 (387 aa) |
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0.796 | ||||||||||
 | UBC | ubiquitin C (685 aa) |
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0.731 | |||||||||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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