ZNF777 protein (Homo sapiens) - STRING network view

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ZNF777

zinc finger protein 777; May be involved in transcriptional regulation (831 aa)

Predicted Functional Partners:

INTS2

0.569

CPAMD8

0.561

XRN1

0.543

WWC3

0.513

OGDHL

0.512

KDM2A

0.501

FBXL19

0.501

KDM2B

0.501

STK36

0.483

PTPN23

0.476

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CPAMD8	INTS2	ENSP00000402505	ENSP00000414237	C3 and PZP-like, alpha-2-macroglobulin domain containing 8	integrator complex subunit 2; Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3’-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes	0.407
CPAMD8	ZNF777	ENSP00000402505	ENSP00000247930	C3 and PZP-like, alpha-2-macroglobulin domain containing 8	zinc finger protein 777; May be involved in transcriptional regulation	0.561
FBXL19	ZNF777	ENSP00000369666	ENSP00000247930	F-box and leucine-rich repeat protein 19; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex (By similarity)	zinc finger protein 777; May be involved in transcriptional regulation	0.501
INTS2	CPAMD8	ENSP00000414237	ENSP00000402505	integrator complex subunit 2; Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3’-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes	C3 and PZP-like, alpha-2-macroglobulin domain containing 8	0.407
INTS2	ZNF777	ENSP00000414237	ENSP00000247930	integrator complex subunit 2; Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3’-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes	zinc finger protein 777; May be involved in transcriptional regulation	0.569
KDM2A	ZNF777	ENSP00000432786	ENSP00000247930	lysine (K)-specific demethylase 2A; Histone demethylase that specifically demethylates ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys- 36’. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at [...]	zinc finger protein 777; May be involved in transcriptional regulation	0.501
KDM2B	ZNF777	ENSP00000366271	ENSP00000247930	lysine (K)-specific demethylase 2B; Histone demethylase that demethylates ’Lys-4’ and ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 ’Lys-4’ and dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys-36’. Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin [...]	zinc finger protein 777; May be involved in transcriptional regulation	0.501
OGDHL	ZNF777	ENSP00000363216	ENSP00000247930	oxoglutarate dehydrogenase-like	zinc finger protein 777; May be involved in transcriptional regulation	0.512
PTPN23	ZNF777	ENSP00000265562	ENSP00000247930	protein tyrosine phosphatase, non-receptor type 23; May act as a negative regulator of Ras-mediated mitogenic activity. Plays a role in ciliogenesis	zinc finger protein 777; May be involved in transcriptional regulation	0.476
STK36	ZNF777	ENSP00000295709	ENSP00000247930	serine/threonine kinase 36; Serine/threonine protein kinase which plays an important role in the sonic hedgehog (Shh) pathway by regulating the activity of GLI transcription factors. Controls the activity of the transcriptional regulators GLI1, GLI2 and GLI3 by opposing the effect of SUFU and promoting their nuclear localization. GLI2 requires an additional function of STK36 to become transcriptionally active, but the enzyme does not need to possess an active kinase catalytic site for this to occur. Required for postnatal development, possibly by regulating the homeostasis of cerebral [...]	zinc finger protein 777; May be involved in transcriptional regulation	0.483
WWC3	ZNF777	ENSP00000370242	ENSP00000247930	WWC family member 3	zinc finger protein 777; May be involved in transcriptional regulation	0.513
XRN1	ZNF777	ENSP00000264951	ENSP00000247930	5’-3’ exoribonuclease 1; Major 5’-3’ exoribonuclease involved in mRNA decay. Required for the 5’-3’-processing of the G4 tetraplex-containing DNA and RNA substrates. The kinetic of hydrolysis is faster for G4 RNA tetraplex than for G4 DNA tetraplex and monomeric RNA tetraplex. Binds to RNA and DNA (By similarity). Plays a role in replication-dependent histone mRNA degradation. May act as a tumor suppressor protein in osteogenic sarcoma (OGS)	zinc finger protein 777; May be involved in transcriptional regulation	0.543
ZNF777	CPAMD8	ENSP00000247930	ENSP00000402505	zinc finger protein 777; May be involved in transcriptional regulation	C3 and PZP-like, alpha-2-macroglobulin domain containing 8	0.561
ZNF777	FBXL19	ENSP00000247930	ENSP00000369666	zinc finger protein 777; May be involved in transcriptional regulation	F-box and leucine-rich repeat protein 19; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex (By similarity)	0.501
ZNF777	INTS2	ENSP00000247930	ENSP00000414237	zinc finger protein 777; May be involved in transcriptional regulation	integrator complex subunit 2; Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3’-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes	0.569
ZNF777	KDM2A	ENSP00000247930	ENSP00000432786	zinc finger protein 777; May be involved in transcriptional regulation	lysine (K)-specific demethylase 2A; Histone demethylase that specifically demethylates ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys- 36’. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at [...]	0.501
ZNF777	KDM2B	ENSP00000247930	ENSP00000366271	zinc finger protein 777; May be involved in transcriptional regulation	lysine (K)-specific demethylase 2B; Histone demethylase that demethylates ’Lys-4’ and ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 ’Lys-4’ and dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys-36’. Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin [...]	0.501
ZNF777	OGDHL	ENSP00000247930	ENSP00000363216	zinc finger protein 777; May be involved in transcriptional regulation	oxoglutarate dehydrogenase-like	0.512
ZNF777	PTPN23	ENSP00000247930	ENSP00000265562	zinc finger protein 777; May be involved in transcriptional regulation	protein tyrosine phosphatase, non-receptor type 23; May act as a negative regulator of Ras-mediated mitogenic activity. Plays a role in ciliogenesis	0.476
ZNF777	STK36	ENSP00000247930	ENSP00000295709	zinc finger protein 777; May be involved in transcriptional regulation	serine/threonine kinase 36; Serine/threonine protein kinase which plays an important role in the sonic hedgehog (Shh) pathway by regulating the activity of GLI transcription factors. Controls the activity of the transcriptional regulators GLI1, GLI2 and GLI3 by opposing the effect of SUFU and promoting their nuclear localization. GLI2 requires an additional function of STK36 to become transcriptionally active, but the enzyme does not need to possess an active kinase catalytic site for this to occur. Required for postnatal development, possibly by regulating the homeostasis of cerebral [...]	0.483

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