node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C16orf70 | KIF17 | ENSP00000219139 | ENSP00000247986 | chromosome 16 open reading frame 70 | kinesin family member 17; Transports vesicles containing N-methyl-D-aspartate (NMDA) receptor 2B along microtubules (By similarity) | 0.914 |
CREM | FHL5 | ENSP00000265372 | ENSP00000326022 | cAMP responsive element modulator | four and a half LIM domains 5; May be involved in the regulation of spermatogenesis. Stimulates CREM transcriptional activity in a phosphorylation- independent manner | 0.989 |
CREM | KIF17 | ENSP00000265372 | ENSP00000247986 | cAMP responsive element modulator | kinesin family member 17; Transports vesicles containing N-methyl-D-aspartate (NMDA) receptor 2B along microtubules (By similarity) | 0.972 |
CREM | PIWIL1 | ENSP00000265372 | ENSP00000245255 | cAMP responsive element modulator | piwi-like 1 (Drosophila); Plays a central role during spermatogenesis by repressing transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Directly binds methylated piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer- independent mechanism and are primarily derived from transposons and ot [...] | 0.885 |
CREM | XPO1 | ENSP00000265372 | ENSP00000384863 | cAMP responsive element modulator | exportin 1 (CRM1 homolog, yeast); Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES) and of RNAs. In the nucleus, in association with RANBP3, binds cooperatively to the NES on its target protein and to the GTPase RAN in its active GTP-bound form (Ran-GTP). Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) c [...] | 0.954 |
DLG3 | KIF17 | ENSP00000363480 | ENSP00000247986 | discs, large homolog 3 (Drosophila); Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling | kinesin family member 17; Transports vesicles containing N-methyl-D-aspartate (NMDA) receptor 2B along microtubules (By similarity) | 0.878 |
FHL5 | CREM | ENSP00000326022 | ENSP00000265372 | four and a half LIM domains 5; May be involved in the regulation of spermatogenesis. Stimulates CREM transcriptional activity in a phosphorylation- independent manner | cAMP responsive element modulator | 0.989 |
FHL5 | KIF17 | ENSP00000326022 | ENSP00000247986 | four and a half LIM domains 5; May be involved in the regulation of spermatogenesis. Stimulates CREM transcriptional activity in a phosphorylation- independent manner | kinesin family member 17; Transports vesicles containing N-methyl-D-aspartate (NMDA) receptor 2B along microtubules (By similarity) | 0.979 |
FHL5 | XPO1 | ENSP00000326022 | ENSP00000384863 | four and a half LIM domains 5; May be involved in the regulation of spermatogenesis. Stimulates CREM transcriptional activity in a phosphorylation- independent manner | exportin 1 (CRM1 homolog, yeast); Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES) and of RNAs. In the nucleus, in association with RANBP3, binds cooperatively to the NES on its target protein and to the GTPase RAN in its active GTP-bound form (Ran-GTP). Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) c [...] | 0.928 |
KCND2 | KIF17 | ENSP00000333496 | ENSP00000247986 | potassium voltage-gated channel, Shal-related subfamily, member 2; Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits | kinesin family member 17; Transports vesicles containing N-methyl-D-aspartate (NMDA) receptor 2B along microtubules (By similarity) | 0.925 |
KIF17 | C16orf70 | ENSP00000247986 | ENSP00000219139 | kinesin family member 17; Transports vesicles containing N-methyl-D-aspartate (NMDA) receptor 2B along microtubules (By similarity) | chromosome 16 open reading frame 70 | 0.914 |
KIF17 | CREM | ENSP00000247986 | ENSP00000265372 | kinesin family member 17; Transports vesicles containing N-methyl-D-aspartate (NMDA) receptor 2B along microtubules (By similarity) | cAMP responsive element modulator | 0.972 |
KIF17 | DLG3 | ENSP00000247986 | ENSP00000363480 | kinesin family member 17; Transports vesicles containing N-methyl-D-aspartate (NMDA) receptor 2B along microtubules (By similarity) | discs, large homolog 3 (Drosophila); Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling | 0.878 |
KIF17 | FHL5 | ENSP00000247986 | ENSP00000326022 | kinesin family member 17; Transports vesicles containing N-methyl-D-aspartate (NMDA) receptor 2B along microtubules (By similarity) | four and a half LIM domains 5; May be involved in the regulation of spermatogenesis. Stimulates CREM transcriptional activity in a phosphorylation- independent manner | 0.979 |
KIF17 | KCND2 | ENSP00000247986 | ENSP00000333496 | kinesin family member 17; Transports vesicles containing N-methyl-D-aspartate (NMDA) receptor 2B along microtubules (By similarity) | potassium voltage-gated channel, Shal-related subfamily, member 2; Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits | 0.925 |
KIF17 | NXF2 | ENSP00000247986 | ENSP00000331471 | kinesin family member 17; Transports vesicles containing N-methyl-D-aspartate (NMDA) receptor 2B along microtubules (By similarity) | nuclear RNA export factor 2 | 0.941 |
KIF17 | NXF2B | ENSP00000247986 | ENSP00000361835 | kinesin family member 17; Transports vesicles containing N-methyl-D-aspartate (NMDA) receptor 2B along microtubules (By similarity) | nuclear RNA export factor 2B; Involved in the export of mRNA from the nucleus to the cytoplasm | 0.944 |
KIF17 | PIWIL1 | ENSP00000247986 | ENSP00000245255 | kinesin family member 17; Transports vesicles containing N-methyl-D-aspartate (NMDA) receptor 2B along microtubules (By similarity) | piwi-like 1 (Drosophila); Plays a central role during spermatogenesis by repressing transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Directly binds methylated piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer- independent mechanism and are primarily derived from transposons and ot [...] | 0.896 |
KIF17 | TSN | ENSP00000247986 | ENSP00000374332 | kinesin family member 17; Transports vesicles containing N-methyl-D-aspartate (NMDA) receptor 2B along microtubules (By similarity) | translin; DNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments. Seems to recognize single-stranded DNA ends generated by staggered breaks occurring at recombination hot spots | 0.874 |
KIF17 | XPO1 | ENSP00000247986 | ENSP00000384863 | kinesin family member 17; Transports vesicles containing N-methyl-D-aspartate (NMDA) receptor 2B along microtubules (By similarity) | exportin 1 (CRM1 homolog, yeast); Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES) and of RNAs. In the nucleus, in association with RANBP3, binds cooperatively to the NES on its target protein and to the GTPase RAN in its active GTP-bound form (Ran-GTP). Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) c [...] | 0.979 |