node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ALOX12B | ALOX15 | ENSP00000315167 | ENSP00000293761 | arachidonate 12-lipoxygenase, 12R type; Converts arachidonic acid to 12R- hydroperoxyeicosatetraenoic acid (12R-HPETE) | arachidonate 15-lipoxygenase; Converts arachidonic acid to 15S- hydroperoxyeicosatetraenoic acid. Also acts on C-12 of arachidonate as well as on linoleic acid | 0.915 |
ALOX12B | ALOX15B | ENSP00000315167 | ENSP00000369530 | arachidonate 12-lipoxygenase, 12R type; Converts arachidonic acid to 12R- hydroperoxyeicosatetraenoic acid (12R-HPETE) | arachidonate 15-lipoxygenase, type B; Converts arachidonic acid exclusively to 15S- hydroperoxyeicosatetraenoic acid, while linoleic acid is less well metabolized | 0.905 |
ALOX12B | PLA2G2C | ENSP00000315167 | ENSP00000247992 | arachidonate 12-lipoxygenase, 12R type; Converts arachidonic acid to 12R- hydroperoxyeicosatetraenoic acid (12R-HPETE) | phospholipase A2, group IIC; Inactive phospholipase (Probable) | 0.907 |
ALOX15 | ALOX12B | ENSP00000293761 | ENSP00000315167 | arachidonate 15-lipoxygenase; Converts arachidonic acid to 15S- hydroperoxyeicosatetraenoic acid. Also acts on C-12 of arachidonate as well as on linoleic acid | arachidonate 12-lipoxygenase, 12R type; Converts arachidonic acid to 12R- hydroperoxyeicosatetraenoic acid (12R-HPETE) | 0.915 |
ALOX15 | ALOX15B | ENSP00000293761 | ENSP00000369530 | arachidonate 15-lipoxygenase; Converts arachidonic acid to 15S- hydroperoxyeicosatetraenoic acid. Also acts on C-12 of arachidonate as well as on linoleic acid | arachidonate 15-lipoxygenase, type B; Converts arachidonic acid exclusively to 15S- hydroperoxyeicosatetraenoic acid, while linoleic acid is less well metabolized | 0.914 |
ALOX15 | PLA2G2C | ENSP00000293761 | ENSP00000247992 | arachidonate 15-lipoxygenase; Converts arachidonic acid to 15S- hydroperoxyeicosatetraenoic acid. Also acts on C-12 of arachidonate as well as on linoleic acid | phospholipase A2, group IIC; Inactive phospholipase (Probable) | 0.915 |
ALOX15B | ALOX12B | ENSP00000369530 | ENSP00000315167 | arachidonate 15-lipoxygenase, type B; Converts arachidonic acid exclusively to 15S- hydroperoxyeicosatetraenoic acid, while linoleic acid is less well metabolized | arachidonate 12-lipoxygenase, 12R type; Converts arachidonic acid to 12R- hydroperoxyeicosatetraenoic acid (12R-HPETE) | 0.905 |
ALOX15B | ALOX15 | ENSP00000369530 | ENSP00000293761 | arachidonate 15-lipoxygenase, type B; Converts arachidonic acid exclusively to 15S- hydroperoxyeicosatetraenoic acid, while linoleic acid is less well metabolized | arachidonate 15-lipoxygenase; Converts arachidonic acid to 15S- hydroperoxyeicosatetraenoic acid. Also acts on C-12 of arachidonate as well as on linoleic acid | 0.914 |
ALOX15B | PLA2G2C | ENSP00000369530 | ENSP00000247992 | arachidonate 15-lipoxygenase, type B; Converts arachidonic acid exclusively to 15S- hydroperoxyeicosatetraenoic acid, while linoleic acid is less well metabolized | phospholipase A2, group IIC; Inactive phospholipase (Probable) | 0.900 |
FADS2 | PLA2G2C | ENSP00000278840 | ENSP00000247992 | fatty acid desaturase 2; Component of a lipid metabolic pathway that catalyzes biosynthesis of highly unsaturated fatty acids (HUFA) from precursor essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18-2n-6) and alpha-linolenic acid (ALA) (18-3n-3). Catalyzes the first and rate limiting step in this pathway which is the desaturation of LA (18-2n-6) and ALA (18-3n-3) into gamma- linoleic acid (GLA) (18-3n-6) and stearidonic acid (18-4n-3) respectively and other desaturation steps. Highly unsaturated fatty acids (HUFA) play pivotal roles in many biological functions. It cat [...] | phospholipase A2, group IIC; Inactive phospholipase (Probable) | 0.901 |
PAFAH1B1 | PLA2G2C | ENSP00000380378 | ENSP00000247992 | platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa); Required for proper activation of Rho GTPases and actin polymerization at the leading edge of locomoting cerebellar neurons and postmigratory hippocampal neurons in response to calcium influx triggered via NMDA receptors. Non-catalytic subunit of an acetylhydrolase complex which inactivates platelet- activating factor (PAF) by removing the acetyl group at the SN-2 position (By similarity). Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated [...] | phospholipase A2, group IIC; Inactive phospholipase (Probable) | 0.900 |
PLA2G2C | ALOX12B | ENSP00000247992 | ENSP00000315167 | phospholipase A2, group IIC; Inactive phospholipase (Probable) | arachidonate 12-lipoxygenase, 12R type; Converts arachidonic acid to 12R- hydroperoxyeicosatetraenoic acid (12R-HPETE) | 0.907 |
PLA2G2C | ALOX15 | ENSP00000247992 | ENSP00000293761 | phospholipase A2, group IIC; Inactive phospholipase (Probable) | arachidonate 15-lipoxygenase; Converts arachidonic acid to 15S- hydroperoxyeicosatetraenoic acid. Also acts on C-12 of arachidonate as well as on linoleic acid | 0.915 |
PLA2G2C | ALOX15B | ENSP00000247992 | ENSP00000369530 | phospholipase A2, group IIC; Inactive phospholipase (Probable) | arachidonate 15-lipoxygenase, type B; Converts arachidonic acid exclusively to 15S- hydroperoxyeicosatetraenoic acid, while linoleic acid is less well metabolized | 0.900 |
PLA2G2C | FADS2 | ENSP00000247992 | ENSP00000278840 | phospholipase A2, group IIC; Inactive phospholipase (Probable) | fatty acid desaturase 2; Component of a lipid metabolic pathway that catalyzes biosynthesis of highly unsaturated fatty acids (HUFA) from precursor essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18-2n-6) and alpha-linolenic acid (ALA) (18-3n-3). Catalyzes the first and rate limiting step in this pathway which is the desaturation of LA (18-2n-6) and ALA (18-3n-3) into gamma- linoleic acid (GLA) (18-3n-6) and stearidonic acid (18-4n-3) respectively and other desaturation steps. Highly unsaturated fatty acids (HUFA) play pivotal roles in many biological functions. It cat [...] | 0.901 |
PLA2G2C | PAFAH1B1 | ENSP00000247992 | ENSP00000380378 | phospholipase A2, group IIC; Inactive phospholipase (Probable) | platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa); Required for proper activation of Rho GTPases and actin polymerization at the leading edge of locomoting cerebellar neurons and postmigratory hippocampal neurons in response to calcium influx triggered via NMDA receptors. Non-catalytic subunit of an acetylhydrolase complex which inactivates platelet- activating factor (PAF) by removing the acetyl group at the SN-2 position (By similarity). Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated [...] | 0.900 |
PLA2G2C | PLD4 | ENSP00000247992 | ENSP00000376372 | phospholipase A2, group IIC; Inactive phospholipase (Probable) | phospholipase D family, member 4 | 0.900 |
PLA2G2C | PNPLA6 | ENSP00000247992 | ENSP00000407509 | phospholipase A2, group IIC; Inactive phospholipase (Probable) | patatin-like phospholipase domain containing 6; Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy | 0.905 |
PLA2G2C | PNPLA7 | ENSP00000247992 | ENSP00000384610 | phospholipase A2, group IIC; Inactive phospholipase (Probable) | patatin-like phospholipase domain containing 7 | 0.905 |
PLA2G2C | PTDSS1 | ENSP00000247992 | ENSP00000430548 | phospholipase A2, group IIC; Inactive phospholipase (Probable) | phosphatidylserine synthase 1; Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) or phosphatidylcholine (PC) is replaced by L-serine. In membranes, PTDSS1 catalyzes mainly the conversion of phosphatidylcholine. Also converts, in vitro and to a lesser extent, phosphatidylethanolamine | 0.900 |