node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AGMO | C5orf4 | ENSP00000341662 | ENSP00000320604 | alkylglycerol monooxygenase; Glyceryl-ether monooxygenase that cleaves the O-alkyl bond of ether lipids. Ether lipids are essential components of brain membranes | chromosome 5 open reading frame 4 | 0.912 |
AGMO | CH25H | ENSP00000341662 | ENSP00000360918 | alkylglycerol monooxygenase; Glyceryl-ether monooxygenase that cleaves the O-alkyl bond of ether lipids. Ether lipids are essential components of brain membranes | cholesterol 25-hydroxylase; Catalyzes the formation of 25-hydroxycholesterol from cholesterol, leading to repress cholesterol biosynthetic enzymes. May play an important role in regulating lipid metabolism by synthesizing a corepressor that blocks sterol regulatory element binding protein (SREBP) processing. In testis, production of 25- hydroxycholesterol by macrophages may play a role in Leydig cell differentiation | 0.899 |
AGMO | CYP4F11 | ENSP00000341662 | ENSP00000248041 | alkylglycerol monooxygenase; Glyceryl-ether monooxygenase that cleaves the O-alkyl bond of ether lipids. Ether lipids are essential components of brain membranes | cytochrome P450, family 4, subfamily F, polypeptide 11 | 0.752 |
AGMO | DHCR7 | ENSP00000341662 | ENSP00000347717 | alkylglycerol monooxygenase; Glyceryl-ether monooxygenase that cleaves the O-alkyl bond of ether lipids. Ether lipids are essential components of brain membranes | 7-dehydrocholesterol reductase; Production of cholesterol by reduction of C7-C8 double bond of 7-dehydrocholesterol (7-DHC) | 0.852 |
AGMO | FDFT1 | ENSP00000341662 | ENSP00000220584 | alkylglycerol monooxygenase; Glyceryl-ether monooxygenase that cleaves the O-alkyl bond of ether lipids. Ether lipids are essential components of brain membranes | farnesyl-diphosphate farnesyltransferase 1 | 0.922 |
AGMO | LBR | ENSP00000341662 | ENSP00000272163 | alkylglycerol monooxygenase; Glyceryl-ether monooxygenase that cleaves the O-alkyl bond of ether lipids. Ether lipids are essential components of brain membranes | lamin B receptor; Anchors the lamina and the heterochromatin to the inner nuclear membrane | 0.852 |
AGMO | LSS | ENSP00000341662 | ENSP00000348762 | alkylglycerol monooxygenase; Glyceryl-ether monooxygenase that cleaves the O-alkyl bond of ether lipids. Ether lipids are essential components of brain membranes | lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase); Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus | 0.851 |
AGMO | MSMO1 | ENSP00000341662 | ENSP00000261507 | alkylglycerol monooxygenase; Glyceryl-ether monooxygenase that cleaves the O-alkyl bond of ether lipids. Ether lipids are essential components of brain membranes | methylsterol monooxygenase 1 | 0.898 |
AGMO | TM7SF2 | ENSP00000341662 | ENSP00000279263 | alkylglycerol monooxygenase; Glyceryl-ether monooxygenase that cleaves the O-alkyl bond of ether lipids. Ether lipids are essential components of brain membranes | transmembrane 7 superfamily member 2; Involved in the conversion of lanosterol to cholesterol | 0.852 |
C5orf4 | AGMO | ENSP00000320604 | ENSP00000341662 | chromosome 5 open reading frame 4 | alkylglycerol monooxygenase; Glyceryl-ether monooxygenase that cleaves the O-alkyl bond of ether lipids. Ether lipids are essential components of brain membranes | 0.912 |
C5orf4 | CH25H | ENSP00000320604 | ENSP00000360918 | chromosome 5 open reading frame 4 | cholesterol 25-hydroxylase; Catalyzes the formation of 25-hydroxycholesterol from cholesterol, leading to repress cholesterol biosynthetic enzymes. May play an important role in regulating lipid metabolism by synthesizing a corepressor that blocks sterol regulatory element binding protein (SREBP) processing. In testis, production of 25- hydroxycholesterol by macrophages may play a role in Leydig cell differentiation | 0.420 |
C5orf4 | CYP4F11 | ENSP00000320604 | ENSP00000248041 | chromosome 5 open reading frame 4 | cytochrome P450, family 4, subfamily F, polypeptide 11 | 0.573 |
C5orf4 | DHCR7 | ENSP00000320604 | ENSP00000347717 | chromosome 5 open reading frame 4 | 7-dehydrocholesterol reductase; Production of cholesterol by reduction of C7-C8 double bond of 7-dehydrocholesterol (7-DHC) | 0.693 |
C5orf4 | FDFT1 | ENSP00000320604 | ENSP00000220584 | chromosome 5 open reading frame 4 | farnesyl-diphosphate farnesyltransferase 1 | 0.860 |
C5orf4 | LBR | ENSP00000320604 | ENSP00000272163 | chromosome 5 open reading frame 4 | lamin B receptor; Anchors the lamina and the heterochromatin to the inner nuclear membrane | 0.693 |
C5orf4 | LSS | ENSP00000320604 | ENSP00000348762 | chromosome 5 open reading frame 4 | lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase); Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus | 0.842 |
C5orf4 | SC5DL | ENSP00000320604 | ENSP00000264027 | chromosome 5 open reading frame 4 | sterol-C5-desaturase (ERG3 delta-5-desaturase homolog, S. cerevisiae)-like; Catalyzes a dehydrogenation to introduce C5-6 double bond into lathosterol | 0.813 |
C5orf4 | TM7SF2 | ENSP00000320604 | ENSP00000279263 | chromosome 5 open reading frame 4 | transmembrane 7 superfamily member 2; Involved in the conversion of lanosterol to cholesterol | 0.968 |
CH25H | AGMO | ENSP00000360918 | ENSP00000341662 | cholesterol 25-hydroxylase; Catalyzes the formation of 25-hydroxycholesterol from cholesterol, leading to repress cholesterol biosynthetic enzymes. May play an important role in regulating lipid metabolism by synthesizing a corepressor that blocks sterol regulatory element binding protein (SREBP) processing. In testis, production of 25- hydroxycholesterol by macrophages may play a role in Leydig cell differentiation | alkylglycerol monooxygenase; Glyceryl-ether monooxygenase that cleaves the O-alkyl bond of ether lipids. Ether lipids are essential components of brain membranes | 0.899 |
CH25H | C5orf4 | ENSP00000360918 | ENSP00000320604 | cholesterol 25-hydroxylase; Catalyzes the formation of 25-hydroxycholesterol from cholesterol, leading to repress cholesterol biosynthetic enzymes. May play an important role in regulating lipid metabolism by synthesizing a corepressor that blocks sterol regulatory element binding protein (SREBP) processing. In testis, production of 25- hydroxycholesterol by macrophages may play a role in Leydig cell differentiation | chromosome 5 open reading frame 4 | 0.420 |