| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| PEX1 | PEX10 | ENSP00000248633 | ENSP00000288774 | peroxisomal biogenesis factor 1; Required for stability of PEX5 and protein import into the peroxisome matrix. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes | peroxisomal biogenesis factor 10; Somewhat implicated in the biogenesis of peroxisomes | 0.914 |
| PEX1 | PEX12 | ENSP00000248633 | ENSP00000225873 | peroxisomal biogenesis factor 1; Required for stability of PEX5 and protein import into the peroxisome matrix. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes | peroxisomal biogenesis factor 12; Required for protein import into peroxisomes | 0.886 |
| PEX1 | PEX13 | ENSP00000248633 | ENSP00000295030 | peroxisomal biogenesis factor 1; Required for stability of PEX5 and protein import into the peroxisome matrix. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes | peroxisomal biogenesis factor 13; Component of the peroxisomal translocation machinery with PEX14 and PEX17. Functions as a docking factor for the predominantly cytoplasmic PTS1 receptor (PAS10/PEX5). Involved in the import of PTS1 and PTS2 proteins | 0.895 |
| PEX1 | PEX19 | ENSP00000248633 | ENSP00000357051 | peroxisomal biogenesis factor 1; Required for stability of PEX5 and protein import into the peroxisome matrix. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes | peroxisomal biogenesis factor 19; Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53 | 0.931 |
| PEX1 | PEX2 | ENSP00000248633 | ENSP00000349543 | peroxisomal biogenesis factor 1; Required for stability of PEX5 and protein import into the peroxisome matrix. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes | peroxisomal biogenesis factor 2; Somewhat implicated in the biogenesis of peroxisomes | 0.870 |
| PEX1 | PEX26 | ENSP00000248633 | ENSP00000331106 | peroxisomal biogenesis factor 1; Required for stability of PEX5 and protein import into the peroxisome matrix. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes | peroxisomal biogenesis factor 26; Probably required for protein import into peroxisomes. Anchors PEX1 and PEX6 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes. Involved in the import of catalase and proteins containing a PTS2 target sequence, but not in import of proteins with a PTS1 target sequence | 0.933 |
| PEX1 | PEX5 | ENSP00000248633 | ENSP00000407401 | peroxisomal biogenesis factor 1; Required for stability of PEX5 and protein import into the peroxisome matrix. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes | peroxisomal biogenesis factor 5; Binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import | 0.958 |
| PEX1 | PEX5L | ENSP00000248633 | ENSP00000419975 | peroxisomal biogenesis factor 1; Required for stability of PEX5 and protein import into the peroxisome matrix. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes | peroxisomal biogenesis factor 5-like; Accessory subunit of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, regulating their cell-surface expression and cyclic nucleotide dependence (By similarity) | 0.832 |
| PEX1 | PEX6 | ENSP00000248633 | ENSP00000303511 | peroxisomal biogenesis factor 1; Required for stability of PEX5 and protein import into the peroxisome matrix. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes | peroxisomal biogenesis factor 6; Involved in peroxisome biosynthesis. Required for stability of the PTS1 receptor. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes | 0.998 |
| PEX1 | UBC | ENSP00000248633 | ENSP00000344818 | peroxisomal biogenesis factor 1; Required for stability of PEX5 and protein import into the peroxisome matrix. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes | ubiquitin C | 0.846 |
| PEX10 | PEX1 | ENSP00000288774 | ENSP00000248633 | peroxisomal biogenesis factor 10; Somewhat implicated in the biogenesis of peroxisomes | peroxisomal biogenesis factor 1; Required for stability of PEX5 and protein import into the peroxisome matrix. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes | 0.914 |
| PEX10 | PEX12 | ENSP00000288774 | ENSP00000225873 | peroxisomal biogenesis factor 10; Somewhat implicated in the biogenesis of peroxisomes | peroxisomal biogenesis factor 12; Required for protein import into peroxisomes | 0.999 |
| PEX10 | PEX13 | ENSP00000288774 | ENSP00000295030 | peroxisomal biogenesis factor 10; Somewhat implicated in the biogenesis of peroxisomes | peroxisomal biogenesis factor 13; Component of the peroxisomal translocation machinery with PEX14 and PEX17. Functions as a docking factor for the predominantly cytoplasmic PTS1 receptor (PAS10/PEX5). Involved in the import of PTS1 and PTS2 proteins | 0.993 |
| PEX10 | PEX19 | ENSP00000288774 | ENSP00000357051 | peroxisomal biogenesis factor 10; Somewhat implicated in the biogenesis of peroxisomes | peroxisomal biogenesis factor 19; Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53 | 0.998 |
| PEX10 | PEX2 | ENSP00000288774 | ENSP00000349543 | peroxisomal biogenesis factor 10; Somewhat implicated in the biogenesis of peroxisomes | peroxisomal biogenesis factor 2; Somewhat implicated in the biogenesis of peroxisomes | 0.997 |
| PEX10 | PEX26 | ENSP00000288774 | ENSP00000331106 | peroxisomal biogenesis factor 10; Somewhat implicated in the biogenesis of peroxisomes | peroxisomal biogenesis factor 26; Probably required for protein import into peroxisomes. Anchors PEX1 and PEX6 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes. Involved in the import of catalase and proteins containing a PTS2 target sequence, but not in import of proteins with a PTS1 target sequence | 0.758 |
| PEX10 | PEX5 | ENSP00000288774 | ENSP00000407401 | peroxisomal biogenesis factor 10; Somewhat implicated in the biogenesis of peroxisomes | peroxisomal biogenesis factor 5; Binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import | 0.992 |
| PEX10 | PEX5L | ENSP00000288774 | ENSP00000419975 | peroxisomal biogenesis factor 10; Somewhat implicated in the biogenesis of peroxisomes | peroxisomal biogenesis factor 5-like; Accessory subunit of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, regulating their cell-surface expression and cyclic nucleotide dependence (By similarity) | 0.906 |
| PEX10 | PEX6 | ENSP00000288774 | ENSP00000303511 | peroxisomal biogenesis factor 10; Somewhat implicated in the biogenesis of peroxisomes | peroxisomal biogenesis factor 6; Involved in peroxisome biosynthesis. Required for stability of the PTS1 receptor. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes | 0.878 |
| PEX10 | UBC | ENSP00000288774 | ENSP00000344818 | peroxisomal biogenesis factor 10; Somewhat implicated in the biogenesis of peroxisomes | ubiquitin C | 0.603 |
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