SPINK2 protein (Homo sapiens) - STRING network view

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SPINK2

serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor); Strong inhibitor of acrosin in male and/or female genital tract. Also inhibits trypsin (84 aa)

Predicted Functional Partners:

SPINK1

0.860

ACR

0.471

SPINK13

0.467

SPINK14

0.452

SPINK6

0.418

ENSG00000258529

0.414

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACR	SPINK2	ENSP00000216139	ENSP00000248701	acrosin; Acrosin is the major protease of mammalian spermatozoa. It is a serine protease of trypsin-like cleavage specificity, it is synthesized in a zymogen form, proacrosin and stored in the acrosome	serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor); Strong inhibitor of acrosin in male and/or female genital tract. Also inhibits trypsin	0.471
ENSG00000258529	SPINK2	ENSP00000456645	ENSP00000248701	Uncharacterized protein	serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor); Strong inhibitor of acrosin in male and/or female genital tract. Also inhibits trypsin	0.414
SPINK1	SPINK2	ENSP00000296695	ENSP00000248701	serine peptidase inhibitor, Kazal type 1; This is a trypsin inhibitor, its physiological function is to prevent the trypsin-catalyzed premature activation of zymogens within the pancreas	serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor); Strong inhibitor of acrosin in male and/or female genital tract. Also inhibits trypsin	0.860
SPINK13	SPINK14	ENSP00000381468	ENSP00000349459	serine peptidase inhibitor, Kazal type 13 (putative); May be a serine protease inhibitor (By similarity)	serine peptidase inhibitor, Kazal type 14 (putative); May be a serine protease inhibitor (By similarity)	0.818
SPINK13	SPINK2	ENSP00000381468	ENSP00000248701	serine peptidase inhibitor, Kazal type 13 (putative); May be a serine protease inhibitor (By similarity)	serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor); Strong inhibitor of acrosin in male and/or female genital tract. Also inhibits trypsin	0.467
SPINK13	SPINK6	ENSP00000381468	ENSP00000324870	serine peptidase inhibitor, Kazal type 13 (putative); May be a serine protease inhibitor (By similarity)	serine peptidase inhibitor, Kazal type 6; Serine protease inhibitor selective for kallikreins. Efficiently inhibits KLK4, KLK5, KLK6, KLK7, KLK12, KLK13 and KLK14. Doesn’t inhibit KLK8	0.756
SPINK14	SPINK13	ENSP00000349459	ENSP00000381468	serine peptidase inhibitor, Kazal type 14 (putative); May be a serine protease inhibitor (By similarity)	serine peptidase inhibitor, Kazal type 13 (putative); May be a serine protease inhibitor (By similarity)	0.818
SPINK14	SPINK2	ENSP00000349459	ENSP00000248701	serine peptidase inhibitor, Kazal type 14 (putative); May be a serine protease inhibitor (By similarity)	serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor); Strong inhibitor of acrosin in male and/or female genital tract. Also inhibits trypsin	0.452
SPINK14	SPINK6	ENSP00000349459	ENSP00000324870	serine peptidase inhibitor, Kazal type 14 (putative); May be a serine protease inhibitor (By similarity)	serine peptidase inhibitor, Kazal type 6; Serine protease inhibitor selective for kallikreins. Efficiently inhibits KLK4, KLK5, KLK6, KLK7, KLK12, KLK13 and KLK14. Doesn’t inhibit KLK8	0.566
SPINK2	ACR	ENSP00000248701	ENSP00000216139	serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor); Strong inhibitor of acrosin in male and/or female genital tract. Also inhibits trypsin	acrosin; Acrosin is the major protease of mammalian spermatozoa. It is a serine protease of trypsin-like cleavage specificity, it is synthesized in a zymogen form, proacrosin and stored in the acrosome	0.471
SPINK2	ENSG00000258529	ENSP00000248701	ENSP00000456645	serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor); Strong inhibitor of acrosin in male and/or female genital tract. Also inhibits trypsin	Uncharacterized protein	0.414
SPINK2	SPINK1	ENSP00000248701	ENSP00000296695	serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor); Strong inhibitor of acrosin in male and/or female genital tract. Also inhibits trypsin	serine peptidase inhibitor, Kazal type 1; This is a trypsin inhibitor, its physiological function is to prevent the trypsin-catalyzed premature activation of zymogens within the pancreas	0.860
SPINK2	SPINK13	ENSP00000248701	ENSP00000381468	serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor); Strong inhibitor of acrosin in male and/or female genital tract. Also inhibits trypsin	serine peptidase inhibitor, Kazal type 13 (putative); May be a serine protease inhibitor (By similarity)	0.467
SPINK2	SPINK14	ENSP00000248701	ENSP00000349459	serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor); Strong inhibitor of acrosin in male and/or female genital tract. Also inhibits trypsin	serine peptidase inhibitor, Kazal type 14 (putative); May be a serine protease inhibitor (By similarity)	0.452
SPINK2	SPINK6	ENSP00000248701	ENSP00000324870	serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor); Strong inhibitor of acrosin in male and/or female genital tract. Also inhibits trypsin	serine peptidase inhibitor, Kazal type 6; Serine protease inhibitor selective for kallikreins. Efficiently inhibits KLK4, KLK5, KLK6, KLK7, KLK12, KLK13 and KLK14. Doesn’t inhibit KLK8	0.418
SPINK6	SPINK13	ENSP00000324870	ENSP00000381468	serine peptidase inhibitor, Kazal type 6; Serine protease inhibitor selective for kallikreins. Efficiently inhibits KLK4, KLK5, KLK6, KLK7, KLK12, KLK13 and KLK14. Doesn’t inhibit KLK8	serine peptidase inhibitor, Kazal type 13 (putative); May be a serine protease inhibitor (By similarity)	0.756
SPINK6	SPINK14	ENSP00000324870	ENSP00000349459	serine peptidase inhibitor, Kazal type 6; Serine protease inhibitor selective for kallikreins. Efficiently inhibits KLK4, KLK5, KLK6, KLK7, KLK12, KLK13 and KLK14. Doesn’t inhibit KLK8	serine peptidase inhibitor, Kazal type 14 (putative); May be a serine protease inhibitor (By similarity)	0.566
SPINK6	SPINK2	ENSP00000324870	ENSP00000248701	serine peptidase inhibitor, Kazal type 6; Serine protease inhibitor selective for kallikreins. Efficiently inhibits KLK4, KLK5, KLK6, KLK7, KLK12, KLK13 and KLK14. Doesn’t inhibit KLK8	serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor); Strong inhibitor of acrosin in male and/or female genital tract. Also inhibits trypsin	0.418

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