node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARL9 | RASL11B | ENSP00000353210 | ENSP00000248706 | ADP-ribosylation factor-like 9 | RAS-like, family 11, member B | 0.816 |
LRIG2 | RASL11B | ENSP00000355396 | ENSP00000248706 | leucine-rich repeats and immunoglobulin-like domains 2 | RAS-like, family 11, member B | 0.684 |
MAP3K19 | NCF4 | ENSP00000365005 | ENSP00000380334 | mitogen-activated protein kinase kinase kinase 19 | neutrophil cytosolic factor 4, 40kDa; Component of the NADPH-oxidase, a multicomponent enzyme system responsible for the oxidative burst in which electrons are transported from NADPH to molecular oxygen, generating reactive oxidant intermediates. It may be important for the assembly and/or activation of the NADPH-oxidase complex | 0.535 |
MAP3K19 | RASGEF1B | ENSP00000365005 | ENSP00000264400 | mitogen-activated protein kinase kinase kinase 19 | RasGEF domain family, member 1B; Guanine nucleotide exchange factor (GEF) with specificity for RAP2A and other Ras family proteins (in vitro) | 0.500 |
MAP3K19 | RASL11B | ENSP00000365005 | ENSP00000248706 | mitogen-activated protein kinase kinase kinase 19 | RAS-like, family 11, member B | 0.709 |
MAP3K19 | SH3PXD2A | ENSP00000365005 | ENSP00000348215 | mitogen-activated protein kinase kinase kinase 19 | SH3 and PX domains 2A; Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of beta-amyloid peptide | 0.535 |
MAP3K19 | SH3PXD2B | ENSP00000365005 | ENSP00000309714 | mitogen-activated protein kinase kinase kinase 19 | SH3 and PX domains 2B; Adapter protein involved in invadopodia and podosome formation and extracellular matrix degradation. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. Plays a role in mitotic clonal expansion during the immediate early stage of adipocyte differentiation (By similarity) | 0.535 |
MAP3K2 | MAP3K3 | ENSP00000343463 | ENSP00000354927 | mitogen-activated protein kinase kinase kinase 2; Component of a protein kinase signal transduction cascade. Regulates the JNK and ERK5 pathways by phosphorylating and activating MAP2K5 and MAP2K7 (By similarity). Plays a role in caveolae kiss-and-run dynamics | mitogen-activated protein kinase kinase kinase 3; Component of a protein kinase signal transduction cascade. Mediates activation of the NF-kappa-B, AP1 and DDIT3 transcriptional regulators | 0.652 |
MAP3K2 | NCF4 | ENSP00000343463 | ENSP00000380334 | mitogen-activated protein kinase kinase kinase 2; Component of a protein kinase signal transduction cascade. Regulates the JNK and ERK5 pathways by phosphorylating and activating MAP2K5 and MAP2K7 (By similarity). Plays a role in caveolae kiss-and-run dynamics | neutrophil cytosolic factor 4, 40kDa; Component of the NADPH-oxidase, a multicomponent enzyme system responsible for the oxidative burst in which electrons are transported from NADPH to molecular oxygen, generating reactive oxidant intermediates. It may be important for the assembly and/or activation of the NADPH-oxidase complex | 0.535 |
MAP3K2 | RASGEF1B | ENSP00000343463 | ENSP00000264400 | mitogen-activated protein kinase kinase kinase 2; Component of a protein kinase signal transduction cascade. Regulates the JNK and ERK5 pathways by phosphorylating and activating MAP2K5 and MAP2K7 (By similarity). Plays a role in caveolae kiss-and-run dynamics | RasGEF domain family, member 1B; Guanine nucleotide exchange factor (GEF) with specificity for RAP2A and other Ras family proteins (in vitro) | 0.500 |
MAP3K2 | RASL11B | ENSP00000343463 | ENSP00000248706 | mitogen-activated protein kinase kinase kinase 2; Component of a protein kinase signal transduction cascade. Regulates the JNK and ERK5 pathways by phosphorylating and activating MAP2K5 and MAP2K7 (By similarity). Plays a role in caveolae kiss-and-run dynamics | RAS-like, family 11, member B | 0.709 |
MAP3K2 | SH3PXD2A | ENSP00000343463 | ENSP00000348215 | mitogen-activated protein kinase kinase kinase 2; Component of a protein kinase signal transduction cascade. Regulates the JNK and ERK5 pathways by phosphorylating and activating MAP2K5 and MAP2K7 (By similarity). Plays a role in caveolae kiss-and-run dynamics | SH3 and PX domains 2A; Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of beta-amyloid peptide | 0.627 |
MAP3K2 | SH3PXD2B | ENSP00000343463 | ENSP00000309714 | mitogen-activated protein kinase kinase kinase 2; Component of a protein kinase signal transduction cascade. Regulates the JNK and ERK5 pathways by phosphorylating and activating MAP2K5 and MAP2K7 (By similarity). Plays a role in caveolae kiss-and-run dynamics | SH3 and PX domains 2B; Adapter protein involved in invadopodia and podosome formation and extracellular matrix degradation. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. Plays a role in mitotic clonal expansion during the immediate early stage of adipocyte differentiation (By similarity) | 0.622 |
MAP3K3 | MAP3K2 | ENSP00000354927 | ENSP00000343463 | mitogen-activated protein kinase kinase kinase 3; Component of a protein kinase signal transduction cascade. Mediates activation of the NF-kappa-B, AP1 and DDIT3 transcriptional regulators | mitogen-activated protein kinase kinase kinase 2; Component of a protein kinase signal transduction cascade. Regulates the JNK and ERK5 pathways by phosphorylating and activating MAP2K5 and MAP2K7 (By similarity). Plays a role in caveolae kiss-and-run dynamics | 0.652 |
MAP3K3 | NCF4 | ENSP00000354927 | ENSP00000380334 | mitogen-activated protein kinase kinase kinase 3; Component of a protein kinase signal transduction cascade. Mediates activation of the NF-kappa-B, AP1 and DDIT3 transcriptional regulators | neutrophil cytosolic factor 4, 40kDa; Component of the NADPH-oxidase, a multicomponent enzyme system responsible for the oxidative burst in which electrons are transported from NADPH to molecular oxygen, generating reactive oxidant intermediates. It may be important for the assembly and/or activation of the NADPH-oxidase complex | 0.535 |
MAP3K3 | RASGEF1B | ENSP00000354927 | ENSP00000264400 | mitogen-activated protein kinase kinase kinase 3; Component of a protein kinase signal transduction cascade. Mediates activation of the NF-kappa-B, AP1 and DDIT3 transcriptional regulators | RasGEF domain family, member 1B; Guanine nucleotide exchange factor (GEF) with specificity for RAP2A and other Ras family proteins (in vitro) | 0.500 |
MAP3K3 | RASL11B | ENSP00000354927 | ENSP00000248706 | mitogen-activated protein kinase kinase kinase 3; Component of a protein kinase signal transduction cascade. Mediates activation of the NF-kappa-B, AP1 and DDIT3 transcriptional regulators | RAS-like, family 11, member B | 0.709 |
MAP3K3 | SH3PXD2A | ENSP00000354927 | ENSP00000348215 | mitogen-activated protein kinase kinase kinase 3; Component of a protein kinase signal transduction cascade. Mediates activation of the NF-kappa-B, AP1 and DDIT3 transcriptional regulators | SH3 and PX domains 2A; Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of beta-amyloid peptide | 0.630 |
MAP3K3 | SH3PXD2B | ENSP00000354927 | ENSP00000309714 | mitogen-activated protein kinase kinase kinase 3; Component of a protein kinase signal transduction cascade. Mediates activation of the NF-kappa-B, AP1 and DDIT3 transcriptional regulators | SH3 and PX domains 2B; Adapter protein involved in invadopodia and podosome formation and extracellular matrix degradation. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. Plays a role in mitotic clonal expansion during the immediate early stage of adipocyte differentiation (By similarity) | 0.634 |
NCF4 | MAP3K19 | ENSP00000380334 | ENSP00000365005 | neutrophil cytosolic factor 4, 40kDa; Component of the NADPH-oxidase, a multicomponent enzyme system responsible for the oxidative burst in which electrons are transported from NADPH to molecular oxygen, generating reactive oxidant intermediates. It may be important for the assembly and/or activation of the NADPH-oxidase complex | mitogen-activated protein kinase kinase kinase 19 | 0.535 |