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STRINGSTRING
MAP3K19 MAP3K19 SH3PXD2B SH3PXD2B NCF4 NCF4 SPATA13 SPATA13 SH3PXD2A SH3PXD2A MAP3K3 MAP3K3 LRIG2 LRIG2 RASL11B RASL11B MAP3K2 MAP3K2 RASGEF1B RASGEF1B ARL9 ARL9
"RASL11B" - RAS-like, family 11, member B in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
RASL11BRAS-like, family 11, member B (248 aa)    
Predicted Functional Partners:
ARL9
ADP-ribosylation factor-like 9 (187 aa)
        score_image   score_image   0.816
MAP3K19
mitogen-activated protein kinase kinase kinase 19 (1328 aa)
        score_image   score_image   0.709
MAP3K3
mitogen-activated protein kinase kinase kinase 3; Component of a protein kinase signal transduction cascade. Mediates activation of the NF-kappa-B, AP1 and DDIT3 transcriptional regulators (657 aa)
        score_image   score_image   0.709
MAP3K2
mitogen-activated protein kinase kinase kinase 2; Component of a protein kinase signal transduction cascade. Regulates the JNK and ERK5 pathways by phosphorylating and activating MAP2K5 and MAP2K7 (By similarity). Plays a role in caveolae kiss-and-run dynamics (619 aa)
        score_image   score_image   0.709
SPATA13
spermatogenesis associated 13 (1277 aa)
        score_image   score_image   0.691
LRIG2
leucine-rich repeats and immunoglobulin-like domains 2 (1065 aa)
        score_image   score_image   0.684
SH3PXD2A
SH3 and PX domains 2A; Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of beta-amyloid peptide (1105 aa)
        score_image   score_image   0.679
NCF4
neutrophil cytosolic factor 4, 40kDa; Component of the NADPH-oxidase, a multicomponent enzyme system responsible for the oxidative burst in which electrons are transported from NADPH to molecular oxygen, generating reactive oxidant intermediates. It may be important for the assembly and/or activation of the NADPH-oxidase complex (348 aa)
        score_image   score_image   0.670
SH3PXD2B
SH3 and PX domains 2B; Adapter protein involved in invadopodia and podosome formation and extracellular matrix degradation. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. Plays a role in mitotic clonal expansion during the immediate early stage of adipocyte differentiation (By similarity) (911 aa)
        score_image   score_image   0.670
RASGEF1B
RasGEF domain family, member 1B; Guanine nucleotide exchange factor (GEF) with specificity for RAP2A and other Ras family proteins (in vitro) (473 aa)
        score_image   score_image   0.667
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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