| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ANPEP | GCLC | ENSP00000300060 | ENSP00000229416 | alanyl (membrane) aminopeptidase; Broad specificity aminopeptidase. Plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. May play a critical role in the pathogenesis of cholesterol gallstone disease. May be involved in the metabolism of regulatory peptides of diverse cell types, responsible for the processing of peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. Found to cleave antigen peptides bound to major histocompatibility complex class II molecules of presenting cells and to degrad [...] | glutamate-cysteine ligase, catalytic subunit | 0.916 |
| ANPEP | GGCT | ENSP00000300060 | ENSP00000275428 | alanyl (membrane) aminopeptidase; Broad specificity aminopeptidase. Plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. May play a critical role in the pathogenesis of cholesterol gallstone disease. May be involved in the metabolism of regulatory peptides of diverse cell types, responsible for the processing of peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. Found to cleave antigen peptides bound to major histocompatibility complex class II molecules of presenting cells and to degrad [...] | gamma-glutamylcyclotransferase; Catalyzes the formation of 5-oxoproline from gamma- glutamyl dipeptides and may play a significant role in glutathione homeostasis. Induces release of cytochrome c from mitochondria with resultant induction of apoptosis | 0.901 |
| ANPEP | GGT1 | ENSP00000300060 | ENSP00000248923 | alanyl (membrane) aminopeptidase; Broad specificity aminopeptidase. Plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. May play a critical role in the pathogenesis of cholesterol gallstone disease. May be involved in the metabolism of regulatory peptides of diverse cell types, responsible for the processing of peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. Found to cleave antigen peptides bound to major histocompatibility complex class II molecules of presenting cells and to degrad [...] | gamma-glutamyltransferase 1; Initiates extracellular glutathione (GSH) breakdown, provides cells with a local cysteine supply and contributes to maintain intracellular GSH level. It is part of the cell antioxidant defense mechanism. Catalyzes the transfer of the glutamyl moiety of glutathione to amino acids and dipeptide acceptors. Alternatively, glutathione can be hydrolyzed to give Cys-Gly and gamma glutamate. Isoform 3 seems to be inactive | 0.940 |
| ANPEP | GSS | ENSP00000300060 | ENSP00000216951 | alanyl (membrane) aminopeptidase; Broad specificity aminopeptidase. Plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. May play a critical role in the pathogenesis of cholesterol gallstone disease. May be involved in the metabolism of regulatory peptides of diverse cell types, responsible for the processing of peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. Found to cleave antigen peptides bound to major histocompatibility complex class II molecules of presenting cells and to degrad [...] | glutathione synthetase | 0.914 |
| GAA | GGCT | ENSP00000305692 | ENSP00000275428 | glucosidase, alpha; acid; Essential for the degradation of glygogen to glucose in lysosomes | gamma-glutamylcyclotransferase; Catalyzes the formation of 5-oxoproline from gamma- glutamyl dipeptides and may play a significant role in glutathione homeostasis. Induces release of cytochrome c from mitochondria with resultant induction of apoptosis | 0.887 |
| GAA | GGT1 | ENSP00000305692 | ENSP00000248923 | glucosidase, alpha; acid; Essential for the degradation of glygogen to glucose in lysosomes | gamma-glutamyltransferase 1; Initiates extracellular glutathione (GSH) breakdown, provides cells with a local cysteine supply and contributes to maintain intracellular GSH level. It is part of the cell antioxidant defense mechanism. Catalyzes the transfer of the glutamyl moiety of glutathione to amino acids and dipeptide acceptors. Alternatively, glutathione can be hydrolyzed to give Cys-Gly and gamma glutamate. Isoform 3 seems to be inactive | 0.941 |
| GAA | GLS | ENSP00000305692 | ENSP00000317379 | glucosidase, alpha; acid; Essential for the degradation of glygogen to glucose in lysosomes | glutaminase; Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine. Plays a role in maintaining acid-base homeostasis. Regulates the levels of the neurotransmitter glutamate in the brain. Isoform 2 lacks catalytic activity | 0.871 |
| GCLC | ANPEP | ENSP00000229416 | ENSP00000300060 | glutamate-cysteine ligase, catalytic subunit | alanyl (membrane) aminopeptidase; Broad specificity aminopeptidase. Plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. May play a critical role in the pathogenesis of cholesterol gallstone disease. May be involved in the metabolism of regulatory peptides of diverse cell types, responsible for the processing of peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. Found to cleave antigen peptides bound to major histocompatibility complex class II molecules of presenting cells and to degrad [...] | 0.916 |
| GCLC | GGCT | ENSP00000229416 | ENSP00000275428 | glutamate-cysteine ligase, catalytic subunit | gamma-glutamylcyclotransferase; Catalyzes the formation of 5-oxoproline from gamma- glutamyl dipeptides and may play a significant role in glutathione homeostasis. Induces release of cytochrome c from mitochondria with resultant induction of apoptosis | 0.905 |
| GCLC | GGT1 | ENSP00000229416 | ENSP00000248923 | glutamate-cysteine ligase, catalytic subunit | gamma-glutamyltransferase 1; Initiates extracellular glutathione (GSH) breakdown, provides cells with a local cysteine supply and contributes to maintain intracellular GSH level. It is part of the cell antioxidant defense mechanism. Catalyzes the transfer of the glutamyl moiety of glutathione to amino acids and dipeptide acceptors. Alternatively, glutathione can be hydrolyzed to give Cys-Gly and gamma glutamate. Isoform 3 seems to be inactive | 0.954 |
| GCLC | GLS | ENSP00000229416 | ENSP00000317379 | glutamate-cysteine ligase, catalytic subunit | glutaminase; Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine. Plays a role in maintaining acid-base homeostasis. Regulates the levels of the neurotransmitter glutamate in the brain. Isoform 2 lacks catalytic activity | 0.814 |
| GCLC | GPX1 | ENSP00000229416 | ENSP00000407375 | glutamate-cysteine ligase, catalytic subunit | glutathione peroxidase 1; Protects the hemoglobin in erythrocytes from oxidative breakdown | 0.716 |
| GCLC | GSR | ENSP00000229416 | ENSP00000221130 | glutamate-cysteine ligase, catalytic subunit | glutathione reductase; Maintains high levels of reduced glutathione in the cytosol | 0.838 |
| GCLC | GSS | ENSP00000229416 | ENSP00000216951 | glutamate-cysteine ligase, catalytic subunit | glutathione synthetase | 0.990 |
| GCLC | GSTA3 | ENSP00000229416 | ENSP00000211122 | glutamate-cysteine ligase, catalytic subunit | glutathione S-transferase alpha 3; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Catalyzes isomerization reactions that contribute to the biosynthesis of steroid hormones. Efficiently catalyze obligatory double-bond isomerizations of delta(5)-androstene-3,17-dione and delta(5)- pregnene-3,20-dione, precursors to testosterone and progesterone, respectively | 0.426 |
| GCLC | GSTP1 | ENSP00000229416 | ENSP00000381607 | glutamate-cysteine ligase, catalytic subunit | glutathione S-transferase pi 1; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration | 0.599 |
| GGCT | ANPEP | ENSP00000275428 | ENSP00000300060 | gamma-glutamylcyclotransferase; Catalyzes the formation of 5-oxoproline from gamma- glutamyl dipeptides and may play a significant role in glutathione homeostasis. Induces release of cytochrome c from mitochondria with resultant induction of apoptosis | alanyl (membrane) aminopeptidase; Broad specificity aminopeptidase. Plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. May play a critical role in the pathogenesis of cholesterol gallstone disease. May be involved in the metabolism of regulatory peptides of diverse cell types, responsible for the processing of peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. Found to cleave antigen peptides bound to major histocompatibility complex class II molecules of presenting cells and to degrad [...] | 0.901 |
| GGCT | GAA | ENSP00000275428 | ENSP00000305692 | gamma-glutamylcyclotransferase; Catalyzes the formation of 5-oxoproline from gamma- glutamyl dipeptides and may play a significant role in glutathione homeostasis. Induces release of cytochrome c from mitochondria with resultant induction of apoptosis | glucosidase, alpha; acid; Essential for the degradation of glygogen to glucose in lysosomes | 0.887 |
| GGCT | GCLC | ENSP00000275428 | ENSP00000229416 | gamma-glutamylcyclotransferase; Catalyzes the formation of 5-oxoproline from gamma- glutamyl dipeptides and may play a significant role in glutathione homeostasis. Induces release of cytochrome c from mitochondria with resultant induction of apoptosis | glutamate-cysteine ligase, catalytic subunit | 0.905 |
| GGCT | GGT1 | ENSP00000275428 | ENSP00000248923 | gamma-glutamylcyclotransferase; Catalyzes the formation of 5-oxoproline from gamma- glutamyl dipeptides and may play a significant role in glutathione homeostasis. Induces release of cytochrome c from mitochondria with resultant induction of apoptosis | gamma-glutamyltransferase 1; Initiates extracellular glutathione (GSH) breakdown, provides cells with a local cysteine supply and contributes to maintain intracellular GSH level. It is part of the cell antioxidant defense mechanism. Catalyzes the transfer of the glutamyl moiety of glutathione to amino acids and dipeptide acceptors. Alternatively, glutathione can be hydrolyzed to give Cys-Gly and gamma glutamate. Isoform 3 seems to be inactive | 0.989 |
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