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STRINGSTRING
VARS2 VARS2 EFNB3 EFNB3 TDRD10 TDRD10 KIAA1919 KIAA1919 ABCA2 ABCA2 SEZ6L SEZ6L ZNF510 ZNF510 MYO18A MYO18A CHRNA10 CHRNA10 MYO18B MYO18B ADRBK2 ADRBK2
"SEZ6L" - seizure related 6 homolog in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
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colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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[Homology]
Score
SEZ6Lseizure related 6 homolog (mouse)-like (1024 aa)    
Predicted Functional Partners:
ADRBK2
adrenergic, beta, receptor kinase 2; Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors (688 aa)
            score_image   0.885
MYO18B
myosin XVIIIB (2567 aa)
            score_image   0.867
TDRD10
tudor domain containing 10 (366 aa)
            score_image   0.658
KIAA1919
KIAA1919; May function as a sodium-dependent glucose transporter (By similarity) (518 aa)
            score_image   0.642
MYO18A
myosin XVIIIA; May be involved in the maintenance of the stromal cell architectures required for cell to cell contact (By similarity). In concert with LURAP1 and CDC42BPA/CDC42BPB, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (2054 aa)
            score_image   0.560
ZNF510
zinc finger protein 510; May be involved in transcriptional regulation (683 aa)
            score_image   0.501
VARS2
valyl-tRNA synthetase 2, mitochondrial (1093 aa)
            score_image   0.478
ABCA2
ATP-binding cassette, sub-family A (ABC1), member 2; Probable transporter, its natural substrate has not been found yet. May have a role in macrophage lipid metabolism and neural development (2436 aa)
            score_image   0.451
EFNB3
ephrin-B3; Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. May play a pivotal role in forebrain function. Binds to, an [...] (340 aa)
            score_image   0.418
CHRNA10
cholinergic receptor, nicotinic, alpha 10 (neuronal); Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and red [...] (450 aa)
            score_image   0.401
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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