| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| APOL2 | AR | ENSP00000249066 | ENSP00000363822 | apolipoprotein L, 2 | androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3 | 0.576 |
| APOL2 | CHRM4 | ENSP00000249066 | ENSP00000409378 | apolipoprotein L, 2 | cholinergic receptor, muscarinic 4; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is inhibition of adenylate cyclase | 0.440 |
| APOL2 | COMT | ENSP00000249066 | ENSP00000354511 | apolipoprotein L, 2 | catechol-O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol | 0.662 |
| APOL2 | OR2AK2 | ENSP00000249066 | ENSP00000355436 | apolipoprotein L, 2 | olfactory receptor, family 2, subfamily AK, member 2; Odorant receptor (Potential) | 0.564 |
| APOL2 | PRODH | ENSP00000249066 | ENSP00000349577 | apolipoprotein L, 2 | proline dehydrogenase (oxidase) 1 | 0.439 |
| APOL2 | SP1 | ENSP00000249066 | ENSP00000329357 | apolipoprotein L, 2 | Sp1 transcription factor; Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Binds also the PDGFR- alpha G-box promoter. May have a role in modulating the cellular response to DNA d [...] | 0.688 |
| APOL2 | TEX33 | ENSP00000249066 | ENSP00000371243 | apolipoprotein L, 2 | testis expressed 33 | 0.408 |
| APOL2 | UBC | ENSP00000249066 | ENSP00000344818 | apolipoprotein L, 2 | ubiquitin C | 0.854 |
| AR | APOL2 | ENSP00000363822 | ENSP00000249066 | androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3 | apolipoprotein L, 2 | 0.576 |
| AR | SP1 | ENSP00000363822 | ENSP00000329357 | androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3 | Sp1 transcription factor; Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Binds also the PDGFR- alpha G-box promoter. May have a role in modulating the cellular response to DNA d [...] | 0.995 |
| AR | UBC | ENSP00000363822 | ENSP00000344818 | androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3 | ubiquitin C | 0.999 |
| CHRM4 | APOL2 | ENSP00000409378 | ENSP00000249066 | cholinergic receptor, muscarinic 4; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is inhibition of adenylate cyclase | apolipoprotein L, 2 | 0.440 |
| COMT | APOL2 | ENSP00000354511 | ENSP00000249066 | catechol-O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol | apolipoprotein L, 2 | 0.662 |
| COMT | PRODH | ENSP00000354511 | ENSP00000349577 | catechol-O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol | proline dehydrogenase (oxidase) 1 | 0.711 |
| COMT | UBC | ENSP00000354511 | ENSP00000344818 | catechol-O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol | ubiquitin C | 0.928 |
| OR2AK2 | APOL2 | ENSP00000355436 | ENSP00000249066 | olfactory receptor, family 2, subfamily AK, member 2; Odorant receptor (Potential) | apolipoprotein L, 2 | 0.564 |
| PRODH | APOL2 | ENSP00000349577 | ENSP00000249066 | proline dehydrogenase (oxidase) 1 | apolipoprotein L, 2 | 0.439 |
| PRODH | COMT | ENSP00000349577 | ENSP00000354511 | proline dehydrogenase (oxidase) 1 | catechol-O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol | 0.711 |
| SP1 | APOL2 | ENSP00000329357 | ENSP00000249066 | Sp1 transcription factor; Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Binds also the PDGFR- alpha G-box promoter. May have a role in modulating the cellular response to DNA d [...] | apolipoprotein L, 2 | 0.688 |
| SP1 | AR | ENSP00000329357 | ENSP00000363822 | Sp1 transcription factor; Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Binds also the PDGFR- alpha G-box promoter. May have a role in modulating the cellular response to DNA d [...] | androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3 | 0.995 |
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