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CDC25C CDC25C CCNB1 CCNB1 CDK1 CDK1 PPP2R2D PPP2R2D MASTL MASTL PPP2R2A PPP2R2A ARPP19 ARPP19 ENSA ENSA ANKRD2 ANKRD2 MINK1 MINK1 ARPP21 ARPP21
"ARPP19" - cAMP-regulated phosphoprotein, 19kDa in Homo sapiens
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protein of unknown 3D structure
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ARPP19cAMP-regulated phosphoprotein, 19kDa; Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. May indirectly enhance GAP-43 expression (112 aa)    
Predicted Functional Partners:
MASTL
microtubule associated serine/threonine kinase-like; Serine/threonine kinase that plays a key role in M phase by acting as a regulator of mitosis entry and maintenance. Acts by promoting the inactivation of protein phosphatase 2A (PP2A) during M phase- does not directly inhibit PP2A but acts by mediating phosphorylation and subsequent activation of ARPP19 and ENSA at ’Ser-62’ and ’Ser-67’, respectively. ARPP19 and ENSA are phosphatase inhibitors that specifically inhibit the PPP2R2D (PR55-delta) subunit of PP2A. Inactivation of PP2A during M phase is essential to keep cyclin-B1-CDK1 ac [...] (879 aa)
          score_image score_image   0.998
CDK1
cyclin-dependent kinase 1; Plays a key role in the control of the eukaryotic cell cycle by modulating the centrosome cycle as well as mitotic onset; promotes G2-M transition, and regulates G1 progress and G1-S transition via association with multiple interphase cyclins. Required in higher cells for entry into S-phase and mitosis. Phosphorylates PARVA/actopaxin, APC, AMPH, APC, BARD1, Bcl- xL/BCL2L1, BRCA2, CALD1, CASP8, CDC7, CDC20, CDC25A, CDC25C, CC2D1A, CSNK2 proteins/CKII, FZR1/CDH1, CDK7, CEBPB, CHAMP1, DMD/dystrophin, EEF1 proteins/EF-1, EZH2, KIF11/EG5, EGFR, FANCG, FOS, GFAP, G [...] (297 aa)
      score_image   score_image score_image   0.950
CCNB1
cyclin B1; Essential for the control of the cell cycle at the G2/M (mitosis) transition (433 aa)
          score_image score_image   0.903
ENSA
endosulfine alpha (137 aa)
          score_image score_image score_image 0.902
PPP2R2D
protein phosphatase 2, regulatory subunit B, delta; B regulatory subunit of protein phosphatase 2A (PP2A) that plays a key role in cell cycle by controlling mitosis entry and exit. The activity of PP2A complexes containing PPP2R2D (PR55- delta) fluctuate during the cell cycle- the activity is high in interphase and low in mitosis. During mitosis, activity of PP2A is inhibited via interaction with phosphorylated ENSA and ARPP19 inhibitors. Within the PP2A complexes, the B regulatory subunits modulate substrate selectivity and catalytic activity, and also may direct the localization of t [...] (422 aa)
            score_image   0.836
ARPP21
cAMP-regulated phosphoprotein, 21kDa; Isoform 2 may act as a competitive inhibitor of calmodulin-dependent enzymes such as calcineurin in neurons (By similarity) (812 aa)
            score_image   0.815
PPP2R2A
protein phosphatase 2, regulatory subunit B, alpha; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment (457 aa)
            score_image   0.799
MINK1
misshapen-like kinase 1; Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking. Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons. Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates- TANC1 upon stimulation by RAP2A, MBP and SMAD1. Has an essential function in negative selection [...] (1332 aa)
            score_image   0.763
ANKRD2
ankyrin repeat domain 2 (stretch responsive muscle); May play an important role in skeletal muscle hypertrophy (360 aa)
            score_image   0.707
CDC25C
cell division cycle 25 homolog C (S. pombe); Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle. When phosphorylated, highly effective in activating G2 cells into prophase. Directly dephosphorylates CDK1 and activates its kinase activity (473 aa)
            score_image   0.699
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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