Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
|
Your Input:
|
Neighborhood |
Gene Fusion |
Cooccurence |
Coexpression |
Experiments |
Databases |
Textmining |
[Homology] |
Score |
|||||
 | THAP10 | THAP domain containing 10 (257 aa) | ||||||||||||
Predicted Functional Partners:
| ||||||||||||||
 | THAP6 | THAP domain containing 6 (222 aa) |
 |
0.649 | ||||||||||
 | LRRC49 | leucine rich repeat containing 49 (686 aa) |
|
0.584 | ||||||||||
 | THAP3 | THAP domain containing, apoptosis associated protein 3; Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1 (239 aa) |
|
0.580 | ||||||||||
 | THAP5 | THAP domain containing 5; May be a regulator of cell cycle- THAP5 overexpression in human cell lines causes cell cycle arrest at G2/M phase (395 aa) |
|
0.569 | ||||||||||
 | THAP9 | THAP domain containing 9; Active transposase that specifically recognizes the bipartite 5’-TXXGGGX(A/T)-3’ consensus motif and mediates transposition (903 aa) |
|
0.567 | ||||||||||
 | PTS | 6-pyruvoyltetrahydropterin synthase; Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6- pyruvoyl tetrahydropterin (145 aa) |
|
0.537 | ||||||||||
 | THAP2 | THAP domain containing, apoptosis associated protein 2 (228 aa) |
|
0.532 | ||||||||||
 | LRRC46 | leucine rich repeat containing 46 (321 aa) |
|
0.459 | ||||||||||
 | DOC2A | double C2-like domains, alpha; Calcium sensor which most probably regulates fusion of vesicles with membranes. Binds calcium and phospholipids. May be involved in calcium dependent neurotransmitter release through the interaction with UNC13A. May be involved in calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Regulates Ca(2+)-dependent secretory lysosome exocytosis in mast cells (400 aa) |
|
0.451 | ||||||||||
 | THAP7 | THAP domain containing 7; Chromatin-associated, histone tail-binding protein that represses transcription via recruitment of HDAC3 and nuclear hormone receptor corepressors (309 aa) |
|
0.450 | ||||||||||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
Share
