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PARVG PARVG ILK ILK ARHGEF7 ARHGEF7 PAK3 PAK3 ARHGEF6 ARHGEF6 PARVB PARVB GIT2 GIT2 GIT1 GIT1 CDC42 CDC42 OPHN1 OPHN1 PAK1 PAK1
"ARHGEF6" - Rac/Cdc42 guanine nucleotide exchange factor in Homo sapiens
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protein of unknown 3D structure
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Predicted Interactions
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ARHGEF6Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6; Acts as a RAC1 guanine nucleotide exchange factor (GEF) (776 aa)    
Predicted Functional Partners:
CDC42
cell division cycle 42 (GTP binding protein, 25kDa); Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Plays a role in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. Mediates CDC42-dependent cell migration (191 aa)
        score_image score_image score_image   0.998
PARVB
parvin, beta (397 aa)
        score_image score_image score_image   0.997
PAK1
p21 protein (Cdc42/Rac)-activated kinase 1; Protein kinase involved in intracellular signaling pathways downstream of integrins and receptor-type kinases that plays an important role in cytoskeleton dynamics, in cell adhesion, migration, proliferation, apoptosis, mitosis, and in vesicle-mediated transport processes. Can directly phosphorylate BAD and protects cells against apoptosis. Activated by interaction with CDC42 and RAC1. Functions as GTPase effector that links the Rho-related GTPases CDC42 and RAC1 to the JNK MAP kinase pathway. Phosphorylates and activates MAP2K1, and thereby [...] (553 aa)
        score_image score_image score_image   0.993
GIT1
G protein-coupled receptor kinase interacting ArfGAP 1; GTPase-activating protein for the ADP ribosylation factor family. May serve as a scaffold to bring together molecules to form signaling modules controlling vesicle trafficking, adhesion and cytoskeletal organization. Increases the speed of cell migration, as well as the size and rate of formation of protrusions, possibly by targeting PAK1 to adhesions and the leading edge of lamellipodia. Sequesters inactive non-tyrosine- phosphorylated paxillin in cytoplasmic complexes (770 aa)
        score_image score_image score_image   0.992
GIT2
G protein-coupled receptor kinase interacting ArfGAP 2; GTPase-activating protein for the ADP ribosylation factor family (759 aa)
        score_image score_image score_image   0.991
ARHGEF7
Rho guanine nucleotide exchange factor (GEF) 7 (803 aa)
        score_image score_image score_image score_image 0.980
PAK3
p21 protein (Cdc42/Rac)-activated kinase 3 (580 aa)
        score_image score_image score_image   0.979
OPHN1
oligophrenin 1; Stimulates GTP hydrolysis of members of the Rho family. Its action on RHOA activity and signaling is implicated in growth and stabilization of dendritic spines, and therefore in synaptic function (By similarity). Critical for the stabilization of AMPA receptors at postsynaptic sites (By similarity). Critical for the regulation of synaptic vesicle endocytosis at presynaptic terminals (By similarity) (802 aa)
          score_image score_image   0.974
ILK
integrin-linked kinase; Receptor-proximal protein kinase regulating integrin- mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B (452 aa)
          score_image score_image   0.973
PARVG
parvin, gamma; Probably plays a role in the regulation of cell adhesion and cytoskeleton organization (By similarity) (331 aa)
          score_image score_image   0.953
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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