node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARHGEF6 | ARHGEF7 | ENSP00000250617 | ENSP00000364893 | Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6; Acts as a RAC1 guanine nucleotide exchange factor (GEF) | Rho guanine nucleotide exchange factor (GEF) 7 | 0.980 |
ARHGEF6 | CDC42 | ENSP00000250617 | ENSP00000314458 | Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6; Acts as a RAC1 guanine nucleotide exchange factor (GEF) | cell division cycle 42 (GTP binding protein, 25kDa); Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Plays a role in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. Mediates CDC42-dependent cell migration | 0.998 |
ARHGEF6 | GIT1 | ENSP00000250617 | ENSP00000378338 | Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6; Acts as a RAC1 guanine nucleotide exchange factor (GEF) | G protein-coupled receptor kinase interacting ArfGAP 1; GTPase-activating protein for the ADP ribosylation factor family. May serve as a scaffold to bring together molecules to form signaling modules controlling vesicle trafficking, adhesion and cytoskeletal organization. Increases the speed of cell migration, as well as the size and rate of formation of protrusions, possibly by targeting PAK1 to adhesions and the leading edge of lamellipodia. Sequesters inactive non-tyrosine- phosphorylated paxillin in cytoplasmic complexes | 0.992 |
ARHGEF6 | GIT2 | ENSP00000250617 | ENSP00000347464 | Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6; Acts as a RAC1 guanine nucleotide exchange factor (GEF) | G protein-coupled receptor kinase interacting ArfGAP 2; GTPase-activating protein for the ADP ribosylation factor family | 0.991 |
ARHGEF6 | ILK | ENSP00000250617 | ENSP00000299421 | Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6; Acts as a RAC1 guanine nucleotide exchange factor (GEF) | integrin-linked kinase; Receptor-proximal protein kinase regulating integrin- mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B | 0.973 |
ARHGEF6 | OPHN1 | ENSP00000250617 | ENSP00000347710 | Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6; Acts as a RAC1 guanine nucleotide exchange factor (GEF) | oligophrenin 1; Stimulates GTP hydrolysis of members of the Rho family. Its action on RHOA activity and signaling is implicated in growth and stabilization of dendritic spines, and therefore in synaptic function (By similarity). Critical for the stabilization of AMPA receptors at postsynaptic sites (By similarity). Critical for the regulation of synaptic vesicle endocytosis at presynaptic terminals (By similarity) | 0.974 |
ARHGEF6 | PAK1 | ENSP00000250617 | ENSP00000278568 | Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6; Acts as a RAC1 guanine nucleotide exchange factor (GEF) | p21 protein (Cdc42/Rac)-activated kinase 1; Protein kinase involved in intracellular signaling pathways downstream of integrins and receptor-type kinases that plays an important role in cytoskeleton dynamics, in cell adhesion, migration, proliferation, apoptosis, mitosis, and in vesicle-mediated transport processes. Can directly phosphorylate BAD and protects cells against apoptosis. Activated by interaction with CDC42 and RAC1. Functions as GTPase effector that links the Rho-related GTPases CDC42 and RAC1 to the JNK MAP kinase pathway. Phosphorylates and activates MAP2K1, and thereby [...] | 0.993 |
ARHGEF6 | PAK3 | ENSP00000250617 | ENSP00000353864 | Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6; Acts as a RAC1 guanine nucleotide exchange factor (GEF) | p21 protein (Cdc42/Rac)-activated kinase 3 | 0.979 |
ARHGEF6 | PARVB | ENSP00000250617 | ENSP00000384515 | Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6; Acts as a RAC1 guanine nucleotide exchange factor (GEF) | parvin, beta | 0.997 |
ARHGEF6 | PARVG | ENSP00000250617 | ENSP00000391453 | Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6; Acts as a RAC1 guanine nucleotide exchange factor (GEF) | parvin, gamma; Probably plays a role in the regulation of cell adhesion and cytoskeleton organization (By similarity) | 0.953 |
ARHGEF7 | ARHGEF6 | ENSP00000364893 | ENSP00000250617 | Rho guanine nucleotide exchange factor (GEF) 7 | Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6; Acts as a RAC1 guanine nucleotide exchange factor (GEF) | 0.980 |
ARHGEF7 | CDC42 | ENSP00000364893 | ENSP00000314458 | Rho guanine nucleotide exchange factor (GEF) 7 | cell division cycle 42 (GTP binding protein, 25kDa); Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Plays a role in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. Mediates CDC42-dependent cell migration | 0.999 |
ARHGEF7 | GIT1 | ENSP00000364893 | ENSP00000378338 | Rho guanine nucleotide exchange factor (GEF) 7 | G protein-coupled receptor kinase interacting ArfGAP 1; GTPase-activating protein for the ADP ribosylation factor family. May serve as a scaffold to bring together molecules to form signaling modules controlling vesicle trafficking, adhesion and cytoskeletal organization. Increases the speed of cell migration, as well as the size and rate of formation of protrusions, possibly by targeting PAK1 to adhesions and the leading edge of lamellipodia. Sequesters inactive non-tyrosine- phosphorylated paxillin in cytoplasmic complexes | 0.999 |
ARHGEF7 | GIT2 | ENSP00000364893 | ENSP00000347464 | Rho guanine nucleotide exchange factor (GEF) 7 | G protein-coupled receptor kinase interacting ArfGAP 2; GTPase-activating protein for the ADP ribosylation factor family | 0.998 |
ARHGEF7 | ILK | ENSP00000364893 | ENSP00000299421 | Rho guanine nucleotide exchange factor (GEF) 7 | integrin-linked kinase; Receptor-proximal protein kinase regulating integrin- mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B | 0.939 |
ARHGEF7 | OPHN1 | ENSP00000364893 | ENSP00000347710 | Rho guanine nucleotide exchange factor (GEF) 7 | oligophrenin 1; Stimulates GTP hydrolysis of members of the Rho family. Its action on RHOA activity and signaling is implicated in growth and stabilization of dendritic spines, and therefore in synaptic function (By similarity). Critical for the stabilization of AMPA receptors at postsynaptic sites (By similarity). Critical for the regulation of synaptic vesicle endocytosis at presynaptic terminals (By similarity) | 0.950 |
ARHGEF7 | PAK1 | ENSP00000364893 | ENSP00000278568 | Rho guanine nucleotide exchange factor (GEF) 7 | p21 protein (Cdc42/Rac)-activated kinase 1; Protein kinase involved in intracellular signaling pathways downstream of integrins and receptor-type kinases that plays an important role in cytoskeleton dynamics, in cell adhesion, migration, proliferation, apoptosis, mitosis, and in vesicle-mediated transport processes. Can directly phosphorylate BAD and protects cells against apoptosis. Activated by interaction with CDC42 and RAC1. Functions as GTPase effector that links the Rho-related GTPases CDC42 and RAC1 to the JNK MAP kinase pathway. Phosphorylates and activates MAP2K1, and thereby [...] | 0.999 |
ARHGEF7 | PAK3 | ENSP00000364893 | ENSP00000353864 | Rho guanine nucleotide exchange factor (GEF) 7 | p21 protein (Cdc42/Rac)-activated kinase 3 | 0.962 |
ARHGEF7 | PARVB | ENSP00000364893 | ENSP00000384515 | Rho guanine nucleotide exchange factor (GEF) 7 | parvin, beta | 0.541 |
CDC42 | ARHGEF6 | ENSP00000314458 | ENSP00000250617 | cell division cycle 42 (GTP binding protein, 25kDa); Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Plays a role in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. Mediates CDC42-dependent cell migration | Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6; Acts as a RAC1 guanine nucleotide exchange factor (GEF) | 0.998 |