ZFYVE26 protein (Homo sapiens) - STRING network view

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Score

ZFYVE26

zinc finger, FYVE domain containing 26 (2539 aa)

Predicted Functional Partners:

AP5Z1

0.970

KIF13A

0.913

SPG11

0.870

AP5B1

0.860

AP5S1

0.860

BECN1

0.836

DDHD1

0.753

SPAST

0.742

TTC19

0.700

RTN1

0.683

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AP5B1	AP5S1	ENSP00000454303	ENSP00000246041	adaptor-related protein complex 5, beta 1 subunit; As part of AP-5, a probable fifth adapter protein complex it may be involved in endosomal transport	adaptor-related protein complex 5, sigma 1 subunit; As part of AP-5, a probable fifth adapter protein complex it may be involved in endosomal transport. According to PubMed-20613862, it is required for efficient homologous recombination DNA double-strand break repair	0.994
AP5B1	AP5Z1	ENSP00000454303	ENSP00000297562	adaptor-related protein complex 5, beta 1 subunit; As part of AP-5, a probable fifth adapter protein complex it may be involved in endosomal transport	adaptor-related protein complex 5, zeta 1 subunit; As part of AP-5, a probable fifth adapter protein complex it may be involved in endosomal transport. According to PubMed-20613862 it is a putative helicase required for efficient homologous recombination DNA double-strand break repair	0.985
AP5B1	SPG11	ENSP00000454303	ENSP00000261866	adaptor-related protein complex 5, beta 1 subunit; As part of AP-5, a probable fifth adapter protein complex it may be involved in endosomal transport	spastic paraplegia 11 (autosomal recessive)	0.860
AP5B1	ZFYVE26	ENSP00000454303	ENSP00000251119	adaptor-related protein complex 5, beta 1 subunit; As part of AP-5, a probable fifth adapter protein complex it may be involved in endosomal transport	zinc finger, FYVE domain containing 26	0.860
AP5S1	AP5B1	ENSP00000246041	ENSP00000454303	adaptor-related protein complex 5, sigma 1 subunit; As part of AP-5, a probable fifth adapter protein complex it may be involved in endosomal transport. According to PubMed-20613862, it is required for efficient homologous recombination DNA double-strand break repair	adaptor-related protein complex 5, beta 1 subunit; As part of AP-5, a probable fifth adapter protein complex it may be involved in endosomal transport	0.994
AP5S1	AP5Z1	ENSP00000246041	ENSP00000297562	adaptor-related protein complex 5, sigma 1 subunit; As part of AP-5, a probable fifth adapter protein complex it may be involved in endosomal transport. According to PubMed-20613862, it is required for efficient homologous recombination DNA double-strand break repair	adaptor-related protein complex 5, zeta 1 subunit; As part of AP-5, a probable fifth adapter protein complex it may be involved in endosomal transport. According to PubMed-20613862 it is a putative helicase required for efficient homologous recombination DNA double-strand break repair	0.985
AP5S1	SPG11	ENSP00000246041	ENSP00000261866	adaptor-related protein complex 5, sigma 1 subunit; As part of AP-5, a probable fifth adapter protein complex it may be involved in endosomal transport. According to PubMed-20613862, it is required for efficient homologous recombination DNA double-strand break repair	spastic paraplegia 11 (autosomal recessive)	0.868
AP5S1	ZFYVE26	ENSP00000246041	ENSP00000251119	adaptor-related protein complex 5, sigma 1 subunit; As part of AP-5, a probable fifth adapter protein complex it may be involved in endosomal transport. According to PubMed-20613862, it is required for efficient homologous recombination DNA double-strand break repair	zinc finger, FYVE domain containing 26	0.860
AP5Z1	AP5B1	ENSP00000297562	ENSP00000454303	adaptor-related protein complex 5, zeta 1 subunit; As part of AP-5, a probable fifth adapter protein complex it may be involved in endosomal transport. According to PubMed-20613862 it is a putative helicase required for efficient homologous recombination DNA double-strand break repair	adaptor-related protein complex 5, beta 1 subunit; As part of AP-5, a probable fifth adapter protein complex it may be involved in endosomal transport	0.985
AP5Z1	AP5S1	ENSP00000297562	ENSP00000246041	adaptor-related protein complex 5, zeta 1 subunit; As part of AP-5, a probable fifth adapter protein complex it may be involved in endosomal transport. According to PubMed-20613862 it is a putative helicase required for efficient homologous recombination DNA double-strand break repair	adaptor-related protein complex 5, sigma 1 subunit; As part of AP-5, a probable fifth adapter protein complex it may be involved in endosomal transport. According to PubMed-20613862, it is required for efficient homologous recombination DNA double-strand break repair	0.985
AP5Z1	DDHD1	ENSP00000297562	ENSP00000327104	adaptor-related protein complex 5, zeta 1 subunit; As part of AP-5, a probable fifth adapter protein complex it may be involved in endosomal transport. According to PubMed-20613862 it is a putative helicase required for efficient homologous recombination DNA double-strand break repair	DDHD domain containing 1; Phospholipase that hydrolyzes phosphatidic acid, including 1,2-dioleoyl-sn-phosphatidic acid. The different isoforms may change the substrate specificity	0.655
AP5Z1	SPAST	ENSP00000297562	ENSP00000320885	adaptor-related protein complex 5, zeta 1 subunit; As part of AP-5, a probable fifth adapter protein complex it may be involved in endosomal transport. According to PubMed-20613862 it is a putative helicase required for efficient homologous recombination DNA double-strand break repair	spastin; ATP-dependent microtubule severing protein. Microtubule severing may promote reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Required for membrane traffic from the endoplasmic reticulum (ER) to the Golgi and for completion of the abscission stage of cytokinesis. Also plays a role in axon growth and the formation of axonal branches (By similarity)	0.544
AP5Z1	SPG11	ENSP00000297562	ENSP00000261866	adaptor-related protein complex 5, zeta 1 subunit; As part of AP-5, a probable fifth adapter protein complex it may be involved in endosomal transport. According to PubMed-20613862 it is a putative helicase required for efficient homologous recombination DNA double-strand break repair	spastic paraplegia 11 (autosomal recessive)	0.970
AP5Z1	ZFYVE26	ENSP00000297562	ENSP00000251119	adaptor-related protein complex 5, zeta 1 subunit; As part of AP-5, a probable fifth adapter protein complex it may be involved in endosomal transport. According to PubMed-20613862 it is a putative helicase required for efficient homologous recombination DNA double-strand break repair	zinc finger, FYVE domain containing 26	0.970
BECN1	ZFYVE26	ENSP00000355231	ENSP00000251119	beclin 1, autophagy related; Plays a central role in autophagy. Required for the abcission step in cytokinesis. May play a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus	zinc finger, FYVE domain containing 26	0.836
DDHD1	AP5Z1	ENSP00000327104	ENSP00000297562	DDHD domain containing 1; Phospholipase that hydrolyzes phosphatidic acid, including 1,2-dioleoyl-sn-phosphatidic acid. The different isoforms may change the substrate specificity	adaptor-related protein complex 5, zeta 1 subunit; As part of AP-5, a probable fifth adapter protein complex it may be involved in endosomal transport. According to PubMed-20613862 it is a putative helicase required for efficient homologous recombination DNA double-strand break repair	0.655
DDHD1	SPG11	ENSP00000327104	ENSP00000261866	DDHD domain containing 1; Phospholipase that hydrolyzes phosphatidic acid, including 1,2-dioleoyl-sn-phosphatidic acid. The different isoforms may change the substrate specificity	spastic paraplegia 11 (autosomal recessive)	0.609
DDHD1	ZFYVE26	ENSP00000327104	ENSP00000251119	DDHD domain containing 1; Phospholipase that hydrolyzes phosphatidic acid, including 1,2-dioleoyl-sn-phosphatidic acid. The different isoforms may change the substrate specificity	zinc finger, FYVE domain containing 26	0.753
KIF13A	TTC19	ENSP00000259711	ENSP00000261647	kinesin family member 13A	tetratricopeptide repeat domain 19; Mitochondrial protein required for formation of the mitochondrial complex III (PubMed-21278747). May also be required for the abcission step in cytokinesis, possibly regulating the ESCRT-III complex via its interaction with CHMP4B (PubMed-20208530). However, the involvement in cytokinesis requires additional experimental evidence	0.572
KIF13A	ZFYVE26	ENSP00000259711	ENSP00000251119	kinesin family member 13A	zinc finger, FYVE domain containing 26	0.913

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