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GNB1 GNB1 PDE6B PDE6B GNGT2 GNGT2 PDE6A PDE6A RHO RHO OPN1SW OPN1SW GNAT2 GNAT2 GNB5 GNB5 CNGB3 CNGB3 PDE6C PDE6C CNGA3 CNGA3
"GNAT2" - guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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some 3D structure is known or predicted
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query proteins and first shell of interactors
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white nodes:
second shell of interactors
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Known Interactions
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experimentally determined
Predicted Interactions
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protein homology
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Score
GNAT2guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Transducin is an amplifier and one of the transducers of a visual impulse that performs the coupling between rhodopsin and cGMP-phosphodiesterase (354 aa)    
Predicted Functional Partners:
GNB1
guanine nucleotide binding protein (G protein), beta polypeptide 1; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction (340 aa)
      score_image score_image score_image score_image   0.991
CNGA3
cyclic nucleotide gated channel alpha 3; Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of cone photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficacy of the channel when coexpressed with CNGB3 (By similarity). Essential for the generation of light-evoked elec [...] (694 aa)
          score_image score_image   0.987
RHO
rhodopsin; Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change leading to G-protein activation and release of all-trans retinal (348 aa)
      score_image score_image score_image score_image   0.986
CNGB3
cyclic nucleotide gated channel beta 3; Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cGMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficiency of the channel when coexpressed with CNGA3 (By similarity). Essential for the generation of light-evoked electrical [...] (809 aa)
          score_image score_image   0.985
PDE6C
phosphodiesterase 6C, cGMP-specific, cone, alpha prime (858 aa)
      score_image score_image score_image score_image   0.983
GNGT2
guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction (By similarity) (69 aa)
      score_image score_image score_image score_image   0.968
GNB5
guanine nucleotide binding protein (G protein), beta 5; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction (395 aa)
      score_image   score_image score_image   0.965
PDE6A
phosphodiesterase 6A, cGMP-specific, rod, alpha; This protein participates in processes of transmission and amplification of the visual signal (860 aa)
      score_image score_image score_image score_image   0.964
OPN1SW
opsin 1 (cone pigments), short-wave-sensitive; Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal (348 aa)
      score_image score_image score_image score_image   0.963
PDE6B
phosphodiesterase 6B, cGMP-specific, rod, beta; This protein participates in processes of transmission and amplification of the visual signal. Necessary for the formation of a functional phosphodiesterase holoenzyme (854 aa)
      score_image score_image score_image score_image   0.961
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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