KHNYN protein (Homo sapiens) - STRING network view

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KHNYN

KH and NYN domain containing (678 aa)

Predicted Functional Partners:

UBC

0.795

SDR39U1

0.441

ZDHHC7

0.436

GZMH

0.422

FAF2

0.420

GUK1

0.401

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FAF2	GUK1	ENSP00000261942	ENSP00000355689	Fas associated factor family member 2; May play a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome	guanylate kinase 1; Essential for recycling GMP and indirectly, cGMP	0.500
FAF2	KHNYN	ENSP00000261942	ENSP00000251343	Fas associated factor family member 2; May play a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome	KH and NYN domain containing	0.420
FAF2	UBC	ENSP00000261942	ENSP00000344818	Fas associated factor family member 2; May play a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome	ubiquitin C	0.991
FAF2	ZDHHC7	ENSP00000261942	ENSP00000341681	Fas associated factor family member 2; May play a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome	zinc finger, DHHC-type containing 7; Palmitoyltransferase with broad specificity. Palmitoylates SNAP25 and DLG4/PSD95. May palmitoylate GABA receptors on their gamma subunit (GABRG1, GABRG2 and GABRG3) and thereby regulate their synaptic clustering and/or cell surface stability (By similarity). Palmitoylates sex steroid hormone receptors, including ESR1, PGR and AR, thereby regulating their targeting to the plasma membrane. This affects rapid intracellular signaling by sex hormones via ERK and AKT kinases and the generation of cAMP, but does not affect that mediated by their nuclear re [...]	0.486
GUK1	FAF2	ENSP00000355689	ENSP00000261942	guanylate kinase 1; Essential for recycling GMP and indirectly, cGMP	Fas associated factor family member 2; May play a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome	0.500
GUK1	KHNYN	ENSP00000355689	ENSP00000251343	guanylate kinase 1; Essential for recycling GMP and indirectly, cGMP	KH and NYN domain containing	0.401
GUK1	UBC	ENSP00000355689	ENSP00000344818	guanylate kinase 1; Essential for recycling GMP and indirectly, cGMP	ubiquitin C	0.727
GUK1	ZDHHC7	ENSP00000355689	ENSP00000341681	guanylate kinase 1; Essential for recycling GMP and indirectly, cGMP	zinc finger, DHHC-type containing 7; Palmitoyltransferase with broad specificity. Palmitoylates SNAP25 and DLG4/PSD95. May palmitoylate GABA receptors on their gamma subunit (GABRG1, GABRG2 and GABRG3) and thereby regulate their synaptic clustering and/or cell surface stability (By similarity). Palmitoylates sex steroid hormone receptors, including ESR1, PGR and AR, thereby regulating their targeting to the plasma membrane. This affects rapid intracellular signaling by sex hormones via ERK and AKT kinases and the generation of cAMP, but does not affect that mediated by their nuclear re [...]	0.482
GZMH	KHNYN	ENSP00000216338	ENSP00000251343	granzyme H (cathepsin G-like 2, protein h-CCPX); Cytotoxic chymotrypsin-like serine protease with preference for bulky and aromatic residues at the P1 position and acidic residues at the P3’ and P4’ sites. Probably necessary for target cell lysis in cell-mediated immune responses. Participates in the antiviral response via direct cleavage of several proteins essential for viral replication	KH and NYN domain containing	0.422
GZMH	SDR39U1	ENSP00000216338	ENSP00000382327	granzyme H (cathepsin G-like 2, protein h-CCPX); Cytotoxic chymotrypsin-like serine protease with preference for bulky and aromatic residues at the P1 position and acidic residues at the P3’ and P4’ sites. Probably necessary for target cell lysis in cell-mediated immune responses. Participates in the antiviral response via direct cleavage of several proteins essential for viral replication	short chain dehydrogenase/reductase family 39U, member 1; Putative NADP-dependent oxidoreductase	0.414
KHNYN	FAF2	ENSP00000251343	ENSP00000261942	KH and NYN domain containing	Fas associated factor family member 2; May play a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome	0.420
KHNYN	GUK1	ENSP00000251343	ENSP00000355689	KH and NYN domain containing	guanylate kinase 1; Essential for recycling GMP and indirectly, cGMP	0.401
KHNYN	GZMH	ENSP00000251343	ENSP00000216338	KH and NYN domain containing	granzyme H (cathepsin G-like 2, protein h-CCPX); Cytotoxic chymotrypsin-like serine protease with preference for bulky and aromatic residues at the P1 position and acidic residues at the P3’ and P4’ sites. Probably necessary for target cell lysis in cell-mediated immune responses. Participates in the antiviral response via direct cleavage of several proteins essential for viral replication	0.422
KHNYN	SDR39U1	ENSP00000251343	ENSP00000382327	KH and NYN domain containing	short chain dehydrogenase/reductase family 39U, member 1; Putative NADP-dependent oxidoreductase	0.441
KHNYN	UBC	ENSP00000251343	ENSP00000344818	KH and NYN domain containing	ubiquitin C	0.795
KHNYN	ZDHHC7	ENSP00000251343	ENSP00000341681	KH and NYN domain containing	zinc finger, DHHC-type containing 7; Palmitoyltransferase with broad specificity. Palmitoylates SNAP25 and DLG4/PSD95. May palmitoylate GABA receptors on their gamma subunit (GABRG1, GABRG2 and GABRG3) and thereby regulate their synaptic clustering and/or cell surface stability (By similarity). Palmitoylates sex steroid hormone receptors, including ESR1, PGR and AR, thereby regulating their targeting to the plasma membrane. This affects rapid intracellular signaling by sex hormones via ERK and AKT kinases and the generation of cAMP, but does not affect that mediated by their nuclear re [...]	0.436
SDR39U1	GZMH	ENSP00000382327	ENSP00000216338	short chain dehydrogenase/reductase family 39U, member 1; Putative NADP-dependent oxidoreductase	granzyme H (cathepsin G-like 2, protein h-CCPX); Cytotoxic chymotrypsin-like serine protease with preference for bulky and aromatic residues at the P1 position and acidic residues at the P3’ and P4’ sites. Probably necessary for target cell lysis in cell-mediated immune responses. Participates in the antiviral response via direct cleavage of several proteins essential for viral replication	0.414
SDR39U1	KHNYN	ENSP00000382327	ENSP00000251343	short chain dehydrogenase/reductase family 39U, member 1; Putative NADP-dependent oxidoreductase	KH and NYN domain containing	0.441
SDR39U1	UBC	ENSP00000382327	ENSP00000344818	short chain dehydrogenase/reductase family 39U, member 1; Putative NADP-dependent oxidoreductase	ubiquitin C	0.483
UBC	FAF2	ENSP00000344818	ENSP00000261942	ubiquitin C	Fas associated factor family member 2; May play a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome	0.991

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