Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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Neighborhood |
Gene Fusion |
Cooccurence |
Coexpression |
Experiments |
Databases |
Textmining |
[Homology] |
Score |
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 | LPPR2 | Lipid phosphate phosphatase-related protein type 2 (343 aa) | ||||||||||||
Predicted Functional Partners:
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 | DOLPP1 | dolichyl pyrophosphate phosphatase 1; Required for efficient N-glycosylation. Necessary for maintaining optimal levels of dolichol-linked oligosaccharides. Hydrolyzes dolichyl pyrophosphate at a very high rate and dolichyl monophosphate at a much lower rate. Does not act on phosphatidate (By similarity) (238 aa) |
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0.721 | ||||||||||
 | KRTCAP3 | keratinocyte associated protein 3 (240 aa) |
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0.591 | ||||||||||
 | PPAPDC3 | phosphatidic acid phosphatase type 2 domain containing 3; Plays a role as negative regulator of myoblast differentiation, in part through effects on MTOR signaling. Has no detectable enzymatic activity (By similarity) (271 aa) |
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0.523 | ||||||||||
 | C16orf58 | chromosome 16 open reading frame 58 (468 aa) |
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0.522 | ||||||||||
 | TMCC1 | transmembrane and coiled-coil domain family 1 (653 aa) |
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0.502 | ||||||||||
 | MARC1 | mitochondrial amidoxime reducing component 1 (337 aa) |
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0.496 | ||||||||||
 | LPHN3 | latrophilin 3 (1469 aa) |
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0.420 | ||||||||||
 | LPHN1 | latrophilin 1; Calcium-independent receptor of high affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor propably implicated in the regulation of exocytosis (By similarity) (1474 aa) |
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0.420 | ||||||||||
 | LPHN2 | latrophilin 2 (1403 aa) |
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0.420 | ||||||||||
 | TMEM38B | transmembrane protein 38B; Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores (By similarity) (291 aa) |
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0.421 | ||||||||||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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